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WormBase Tree Display for Gene: WBGene00006575

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Name Class

WBGene00006575SMapS_parentSequenceF13B10
IdentityVersion2
NameCGC_nametir-1Person_evidenceWBPerson168
Sequence_nameF13B10.1
Molecular_name (29)
Other_namensy-2Paper_evidenceWBPaper00024676
Person_evidenceWBPerson42
CELE_F13B10.1Accession_evidenceNDBBX284603
Public_nametir-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
209 Nov 2005 10:42:10WBPerson2970EventAcquires_mergeWBGene00003823
Name_changeOther_namensy-2
Acquires_mergeWBGene00003823
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classtir
Allele (424)
Possibly_affected_byWBVar02152927
StrainWBStrain00031789
WBStrain00032827
WBStrain00035844
WBStrain00040806
WBStrain00005265
WBStrain00021983
WBStrain00021984
RNASeq_FPKM (74)
GO_annotation (53)
Ortholog (53)
Structured_descriptionConcise_descriptiontir-1 encodes a Toll-Interleukin 1 Receptor (TIR) domain adaptor protein that is the C. elegans ortholog of human SARM (sterile alpha and armadillo repeats); tir-1 is required for innate immunity, as loss of tir-1 activity results in increased susceptibility to infection; tir-1 also functions in a lateral signaling pathway that specifies neuronal identity and is required for proper localization of NSY-1/MAPKKK to post-synaptic regions; TIR-1 physically interacts with a number of proteins, including UNC-43/CaMKII, the RAB-1 GTPase, and the ATP synthase f subunit encoded by R53.4; TIR-1 is expressed in neurons and localizes to post-synaptic regions of axons.Paper_evidenceWBPaper00004589
WBPaper00006488
WBPaper00006511
WBPaper00024676
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated22 Mar 2013 00:00:00
Automated_descriptionEnables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Expressed in head. Used to study amyotrophic lateral sclerosis. Is an ortholog of human SARM1 (sterile alpha and TIR motif containing 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:332Homo sapiensPaper_evidenceWBPaper00046914
Curator_confirmedWBPerson324
Date_last_updated15 Jul 2015 00:00:00
Models_disease_in_annotationWBDOannot00000352
Molecular_infoCorresponding_CDSF13B10.1a
F13B10.1b
F13B10.1c
F13B10.1d
F13B10.1e
F13B10.1f
F13B10.1g
F13B10.1h
Corresponding_CDS_historyF13B10.1c:wp248
Corresponding_transcript (13)
Other_sequence (45)
Associated_feature (48)
Experimental_infoRNAi_resultWBRNAi00097060Inferred_automaticallyRNAi_primary
WBRNAi00063701Inferred_automaticallyRNAi_primary
WBRNAi00068001Inferred_automaticallyRNAi_primary
WBRNAi00065513Inferred_automaticallyRNAi_primary
WBRNAi00087265Inferred_automaticallyRNAi_primary
WBRNAi00071257Inferred_automaticallyRNAi_primary
WBRNAi00092952Inferred_automaticallyRNAi_primary
WBRNAi00073458Inferred_automaticallyRNAi_primary
WBRNAi00071903Inferred_automaticallyRNAi_primary
WBRNAi00082212Inferred_automaticallyRNAi_primary
WBRNAi00063698Inferred_automaticallyRNAi_primary
WBRNAi00110830Inferred_automaticallyRNAi_primary
WBRNAi00087263Inferred_automaticallyRNAi_primary
WBRNAi00073459Inferred_automaticallyRNAi_primary
WBRNAi00075822Inferred_automaticallyRNAi_primary
WBRNAi00082215Inferred_automaticallyRNAi_primary
WBRNAi00069081Inferred_automaticallyRNAi_primary
WBRNAi00095256Inferred_automaticallyRNAi_primary
WBRNAi00077229Inferred_automaticallyRNAi_primary
WBRNAi00005993Inferred_automaticallyRNAi_primary
WBRNAi00073456Inferred_automaticallyRNAi_primary
WBRNAi00068749Inferred_automaticallyRNAi_primary
WBRNAi00073457Inferred_automaticallyRNAi_primary
WBRNAi00082214Inferred_automaticallyRNAi_primary
WBRNAi00088601Inferred_automaticallyRNAi_primary
WBRNAi00082213Inferred_automaticallyRNAi_primary
WBRNAi00077228Inferred_automaticallyRNAi_primary
WBRNAi00086739Inferred_automaticallyRNAi_primary
WBRNAi00077209Inferred_automaticallyRNAi_primary
WBRNAi00087264Inferred_automaticallyRNAi_primary
WBRNAi00030869Inferred_automaticallyRNAi_primary
WBRNAi00082216Inferred_automaticallyRNAi_primary
WBRNAi00112045Inferred_automaticallyRNAi_primary
WBRNAi00073460Inferred_automaticallyRNAi_primary
WBRNAi00013188Inferred_automaticallyRNAi_primary
WBRNAi00077230Inferred_automaticallyRNAi_primary
WBRNAi00112044Inferred_automaticallyRNAi_primary
WBRNAi00065509Inferred_automaticallyRNAi_primary
WBRNAi00111495Inferred_automaticallyRNAi_primary
WBRNAi00088708Inferred_automaticallyRNAi_primary
WBRNAi00068809Inferred_automaticallyRNAi_primary
WBRNAi00077227Inferred_automaticallyRNAi_primary
WBRNAi00072252Inferred_automaticallyRNAi_primary
WBRNAi00073455Inferred_automaticallyRNAi_primary
WBRNAi00077231Inferred_automaticallyRNAi_primary
WBRNAi00077213Inferred_automaticallyRNAi_primary
WBRNAi00086737Inferred_automaticallyRNAi_primary
WBRNAi00044472Inferred_automaticallyRNAi_primary
WBRNAi00073454Inferred_automaticallyRNAi_primary
WBRNAi00078850Inferred_automaticallyRNAi_primary
WBRNAi00095436Inferred_automaticallyRNAi_primary
WBRNAi00077226Inferred_automaticallyRNAi_primary
WBRNAi00077205Inferred_automaticallyRNAi_primary
Expr_patternExpr3964
Expr3965
Expr5747
Expr14886
Expr1025922
Expr1032710
Expr1148422
Expr2017410
Expr2035549
Drives_constructWBCnstr00002582
WBCnstr00006461
Construct_product (18)
AntibodyWBAntibody00001006
WBAntibody00001007
Microarray_results (57)
Expression_cluster (277)
Interaction (168)
WBProcessWBbiopr:00000001
WBbiopr:00000008
WBbiopr:00000014
WBbiopr:00000039
Map_infoMapIIIPosition-4.2469Error0.000352
PositivePositive_cloneF13B10Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point (2)
Pos_neg_data10953
10954
10955
Pseudo_map_position
Reference (122)
PictureWBPicture0000013079
WBPicture0000013081
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene