WormBase Tree Display for Gene: WBGene00004333
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WBGene00004333 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | W02A2 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | rec-8 | Person_evidence | WBPerson533 | |||||
Sequence_name | W02A2.6 | ||||||||
Molecular_name | W02A2.6a | ||||||||
W02A2.6a.1 | |||||||||
CE21236 | |||||||||
W02A2.6b | |||||||||
CE45697 | |||||||||
W02A2.6c | |||||||||
CE45566 | |||||||||
W02A2.6b.1 | |||||||||
W02A2.6c.1 | |||||||||
Other_name | CELE_W02A2.6 | Accession_evidence | NDB | BX284604 | |||||
Public_name | rec-8 | ||||||||
DB_info | Database | AceView | gene | 4O114 | |||||
WormQTL | gene | WBGene00004333 | |||||||
WormFlux | gene | WBGene00004333 | |||||||
NDB | locus_tag | CELE_W02A2.6 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004333|UniProtKB=Q9XUB3 | |||||||
family | PTHR12585 | ||||||||
NCBI | gene | 178295 | |||||||
RefSeq | protein | NM_001268800.3 | |||||||
NM_001268799.3 | |||||||||
NM_001268798.3 | |||||||||
SwissProt | UniProtAcc | Q9XUB3 | |||||||
UniProt_GCRP | UniProtAcc | Q9XUB3 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | rec | ||||||||
Allele (63) | |||||||||
Legacy_information | RNAi phenotypes: >90% embryonic lethality, HIM (11% males); loss of meiotic chromosome pairing and sister chromatid cohesion; meiotic nondisjunction; protein localizes to axes of chromosomes at meiotic prophase | ||||||||
Strain | WBStrain00035158 | ||||||||
WBStrain00035162 | |||||||||
WBStrain00035163 | |||||||||
WBStrain00035963 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (34) | |||||||||
Ortholog (19) | |||||||||
Structured_description | Concise_description | rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase. | Paper_evidence | WBPaper00004722 | |||||
WBPaper00004997 | |||||||||
WBPaper00005919 | |||||||||
WBPaper00006163 | |||||||||
WBPaper00018756 | |||||||||
WBPaper00019729 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in double-strand break repair and organelle organization. Located in nuclear lumen and spindle. Part of chromatin. Expressed in Z2; Z3; embryonic cell; and gonad. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info (4) | |||||||||
Experimental_info | RNAi_result | WBRNAi00036166 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00081201 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00000353 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081202 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00083896 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081196 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00083897 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081197 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063291 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081200 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00005008 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081203 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063294 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00022925 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081204 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081208 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088918 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081207 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081198 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00019482 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062855 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081199 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00103810 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00054548 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00083899 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr2451 | ||||||||
Expr11542 | |||||||||
Expr12238 | |||||||||
Expr16473 | |||||||||
Expr1017580 | |||||||||
Expr1032151 | |||||||||
Expr1158093 | |||||||||
Expr2015291 | |||||||||
Expr2033525 | |||||||||
Drives_construct | WBCnstr00035561 | ||||||||
Construct_product | WBCnstr00035561 | ||||||||
Antibody (15) | |||||||||
Microarray_results (21) | |||||||||
Expression_cluster (125) | |||||||||
Interaction (83) | |||||||||
WBProcess | WBbiopr:00000099 | ||||||||
Map_info | Map | IV | Position | 8.53422 | Error | 0.001584 | |||
Positive | Positive_clone | W02A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4298 | |||||||
Pseudo_map_position | |||||||||
Reference (75) | |||||||||
Remark | [J. Loidl] rec-8 (W02A2.6) is the likely ortholog of S. cerevisiae rec8 meiosis-specific cohesion protein | ||||||||
Sequence connection from [Loidl J] | |||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |