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WormBase Tree Display for Gene: WBGene00001746

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Name Class

WBGene00001746EvidencePerson_evidenceWBPerson1698
SMapS_parentSequenceY18D10A
IdentityVersion1
NameCGC_namegsk-3Person_evidenceWBPerson75
Sequence_nameY18D10A.5
Molecular_name (3)
Other_namesgg-1
Y18D10A.fCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_Y18D10A.5Accession_evidenceNDBBX284601
Public_namegsk-3
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgsk
Allele (132)
Possibly_affected_byWBVar02153198
StrainWBStrain00040436
WBStrain00000267
WBStrain00024318
RNASeq_FPKM (74)
GO_annotation (41)
Ortholog (48)
ParalogWBGene00010991Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00008095Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptiongsk-3 encodes the C. elegans glycogen synthase kinase ortholog; during embryonic development, GSK-3 functions in the Wnt signaling pathway that restricts specification of mesendodermal tissue to the appropriate blastomere; GSK-3 also functions in a Wnt pathway that regulates anteroposterior axon guidance; GSK-3 plays a role in regulating the oocyte-to-embryo transition, by phosphorylating and negatively regulating the OMA-1 zinc finger protein, and in regulation of the oxidative stress response pathway by phosphorylating SKN-1, thereby excluding it from intestinal nuclei; GSK-3, along with MOM-5/Frizzled and APR-1/APC is also required for distal tip cell migration in the gonad and for the engulfment of apoptotic cells, indicating that the Wnt pathway signals to CED-10/Rac to regulate cytoskeletal rearrangement during different cellular processes; GSK-3 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo; consistent with this, GSK-3 phosphorylation is absent in mpk-1 mutant animals.Paper_evidenceWBPaper00004636
WBPaper00026924
WBPaper00027607
WBPaper00032955
WBPaper00035874
WBPaper00032961
Curator_confirmedWBPerson1843
WBPerson324
Date_last_updated23 Jan 2012 00:00:00
Automated_descriptionEnables protein serine/threonine kinase activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and regulation of cellular component organization. Predicted to be located in cytosol and nucleus. Expressed in distal tip cell; seam cell; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; carcinoma (multiple); and degenerative disc disease. Is an ortholog of human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
DOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
DOID:3312Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
DOID:2871Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
DOID:0050861Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
DOID:332Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4616,HGNC:4617)
DOID:90Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
DOID:5419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4617)
Molecular_infoCorresponding_CDSY18D10A.5
Corresponding_transcriptY18D10A.5.1
Other_sequence (86)
Associated_featureWBsf981118
WBsf1010971
WBsf218641
WBsf218642
Experimental_infoRNAi_resultWBRNAi00098852Inferred_automaticallyRNAi_primary
WBRNAi00067783Inferred_automaticallyRNAi_primary
WBRNAi00000122Inferred_automaticallyRNAi_primary
WBRNAi00106577Inferred_automaticallyRNAi_primary
WBRNAi00097718Inferred_automaticallyRNAi_primary
WBRNAi00000695Inferred_automaticallyRNAi_primary
WBRNAi00091902Inferred_automaticallyRNAi_primary
WBRNAi00115711Inferred_automaticallyRNAi_primary
WBRNAi00077085Inferred_automaticallyRNAi_primary
WBRNAi00101304Inferred_automaticallyRNAi_primary
WBRNAi00097071Inferred_automaticallyRNAi_primary
WBRNAi00111755Inferred_automaticallyRNAi_primary
WBRNAi00104220Inferred_automaticallyRNAi_primary
WBRNAi00084505Inferred_automaticallyRNAi_primary
WBRNAi00104218Inferred_automaticallyRNAi_primary
WBRNAi00098804Inferred_automaticallyRNAi_primary
WBRNAi00108263Inferred_automaticallyRNAi_primary
WBRNAi00098849Inferred_automaticallyRNAi_primary
WBRNAi00060204Inferred_automaticallyRNAi_primary
WBRNAi00104238Inferred_automaticallyRNAi_primary
WBRNAi00084507Inferred_automaticallyRNAi_primary
WBRNAi00055619Inferred_automaticallyRNAi_primary
WBRNAi00064255Inferred_automaticallyRNAi_primary
WBRNAi00079046Inferred_automaticallyRNAi_primary
WBRNAi00104233Inferred_automaticallyRNAi_primary
WBRNAi00092536Inferred_automaticallyRNAi_primary
WBRNAi00106588Inferred_automaticallyRNAi_primary
WBRNAi00098805Inferred_automaticallyRNAi_primary
WBRNAi00104239Inferred_automaticallyRNAi_primary
WBRNAi00064554Inferred_automaticallyRNAi_primary
WBRNAi00077084Inferred_automaticallyRNAi_primary
WBRNAi00104227Inferred_automaticallyRNAi_primary
WBRNAi00079064Inferred_automaticallyRNAi_primary
WBRNAi00078323Inferred_automaticallyRNAi_primary
WBRNAi00098806Inferred_automaticallyRNAi_primary
WBRNAi00104228Inferred_automaticallyRNAi_primary
WBRNAi00098803Inferred_automaticallyRNAi_primary
WBRNAi00104236Inferred_automaticallyRNAi_primary
WBRNAi00104241Inferred_automaticallyRNAi_primary
WBRNAi00067010Inferred_automaticallyRNAi_primary
WBRNAi00098807Inferred_automaticallyRNAi_primary
WBRNAi00061058Inferred_automaticallyRNAi_primary
WBRNAi00084504Inferred_automaticallyRNAi_primary
WBRNAi00062618Inferred_automaticallyRNAi_primary
WBRNAi00115613Inferred_automaticallyRNAi_primary
WBRNAi00104221Inferred_automaticallyRNAi_primary
WBRNAi00104217Inferred_automaticallyRNAi_primary
WBRNAi00067888Inferred_automaticallyRNAi_primary
WBRNAi00101860Inferred_automaticallyRNAi_primary
WBRNAi00077083Inferred_automaticallyRNAi_primary
WBRNAi00079063Inferred_automaticallyRNAi_primary
WBRNAi00080775Inferred_automaticallyRNAi_primary
WBRNAi00098799Inferred_automaticallyRNAi_primary
WBRNAi00067684Inferred_automaticallyRNAi_primary
WBRNAi00108264Inferred_automaticallyRNAi_primary
WBRNAi00060202Inferred_automaticallyRNAi_primary
WBRNAi00098813Inferred_automaticallyRNAi_primary
WBRNAi00104223Inferred_automaticallyRNAi_primary
WBRNAi00084506Inferred_automaticallyRNAi_primary
WBRNAi00104235Inferred_automaticallyRNAi_primary
WBRNAi00104231Inferred_automaticallyRNAi_primary
WBRNAi00079044Inferred_automaticallyRNAi_primary
WBRNAi00101945Inferred_automaticallyRNAi_primary
WBRNAi00101479Inferred_automaticallyRNAi_primary
WBRNAi00071070Inferred_automaticallyRNAi_primary
WBRNAi00067408Inferred_automaticallyRNAi_primary
WBRNAi00104232Inferred_automaticallyRNAi_primary
WBRNAi00064715Inferred_automaticallyRNAi_primary
WBRNAi00104226Inferred_automaticallyRNAi_primary
WBRNAi00101893Inferred_automaticallyRNAi_primary
WBRNAi00097078Inferred_automaticallyRNAi_primary
WBRNAi00081319Inferred_automaticallyRNAi_primary
WBRNAi00036702Inferred_automaticallyRNAi_primary
WBRNAi00104234Inferred_automaticallyRNAi_primary
WBRNAi00062628Inferred_automaticallyRNAi_primary
WBRNAi00061055Inferred_automaticallyRNAi_primary
WBRNAi00084503Inferred_automaticallyRNAi_primary
WBRNAi00067475Inferred_automaticallyRNAi_primary
WBRNAi00115612Inferred_automaticallyRNAi_primary
WBRNAi00062619Inferred_automaticallyRNAi_primary
WBRNAi00026621Inferred_automaticallyRNAi_primary
WBRNAi00104216Inferred_automaticallyRNAi_primary
WBRNAi00080776Inferred_automaticallyRNAi_primary
WBRNAi00062602Inferred_automaticallyRNAi_primary
WBRNAi00062627Inferred_automaticallyRNAi_primary
WBRNAi00067452Inferred_automaticallyRNAi_primary
WBRNAi00104240Inferred_automaticallyRNAi_primary
WBRNAi00062616Inferred_automaticallyRNAi_primary
WBRNAi00104230Inferred_automaticallyRNAi_primary
WBRNAi00079045Inferred_automaticallyRNAi_primary
WBRNAi00104215Inferred_automaticallyRNAi_primary
WBRNAi00104224Inferred_automaticallyRNAi_primary
WBRNAi00104219Inferred_automaticallyRNAi_primary
WBRNAi00098846Inferred_automaticallyRNAi_primary
WBRNAi00060205Inferred_automaticallyRNAi_primary
WBRNAi00098845Inferred_automaticallyRNAi_primary
WBRNAi00104229Inferred_automaticallyRNAi_primary
WBRNAi00077082Inferred_automaticallyRNAi_primary
WBRNAi00080697Inferred_automaticallyRNAi_primary
WBRNAi00104225Inferred_automaticallyRNAi_primary
WBRNAi00104237Inferred_automaticallyRNAi_primary
WBRNAi00115704Inferred_automaticallyRNAi_primary
WBRNAi00098927Inferred_automaticallyRNAi_primary
WBRNAi00101357Inferred_automaticallyRNAi_primary
WBRNAi00060203Inferred_automaticallyRNAi_primary
WBRNAi00067746Inferred_automaticallyRNAi_primary
WBRNAi00066942Inferred_automaticallyRNAi_primary
WBRNAi00026622Inferred_automaticallyRNAi_primary
WBRNAi00116720Inferred_automaticallyRNAi_primary
WBRNAi00106703Inferred_automaticallyRNAi_primary
WBRNAi00071849Inferred_automaticallyRNAi_primary
WBRNAi00104222Inferred_automaticallyRNAi_primary
WBRNAi00101852Inferred_automaticallyRNAi_primary
Expr_patternExpr13709
Expr15114
Expr1012893
Expr1031039
Expr1159129
Expr2012283
Expr2030519
Construct_productWBCnstr00000615
AntibodyWBAntibody00001673
Microarray_results (21)
Expression_cluster (92)
Interaction (309)
Anatomy_functionWBbtf0749
WBProcessWBbiopr:00000073
Map_infoMapIPosition14.0947Error0.019406
PositivePositive_cloneY18D10AInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4534
4967
Pseudo_map_position
Reference (98)
Remarkgsk-3 is the main name for sgg-1
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene