WormBase Tree Display for Gene: WBGene00010890

WBGene00010890 SMap: S_parent: Sequence: M18
  Identity: Version: 2
    Name: CGC_name: ddb-1 Person_evidence: WBPerson322
      Sequence_name: M18.5
      Molecular_name: M18.5
        M18.5.1
        CE23880
      Other_name: CELE_M18.5 Accession_evidence: NDB BX284604
      Public_name: ddb-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Feb 2006 09:28:57 WBPerson2970 Name_change: CGC_name: ddb-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ddb
    Allele (75)
    Possibly_affected_by: WBVar02152930
    Strain: WBStrain00007247
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (38)
    Paralog: WBGene00019323 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022301 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ddb-1 encodes a protein orthologous to human DNA damage-binding protein 1 (DDB1); ddb-1 is part of a ubiquitin ligase E3 complex, CUL-4/DDB-1, and targets the replication licensing factor, cdt-1, for ubiquitin-mediated proteolysis; ddb-1 interacts physically with CUL-4/Cullin and CDT-1; the CUL-4/DDB-1 complex also regulates SKN-1 transcription factor activity, and LET-23/EGFR signalling in vulval precursor cells. Paper_evidence: WBPaper00028868
            WBPaper00037735
            WBPaper00032980
          Curator_confirmed: WBPerson1843
            WBPerson324
            WBPerson1823
            WBPerson567
          Date_last_updated: 07 May 2013 00:00:00
      Automated_description: Predicted to enable DNA binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and rectum. Used to study xeroderma pigmentosum. Is an ortholog of human DDB1 (damage specific DNA binding protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0050427 Homo sapiens Paper_evidence: WBPaper00028868
          Curator_confirmed: WBPerson324
          Date_last_updated: 13 Mar 2023 00:00:00
    Potential_model: DOID:2033 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2717)
    Disease_relevance: The human DNA damage-binding protein 1 (DDB1; orthologous to elegans ddb-1) is required for ultraviolet light-damaged DNA repair and binds to DDB2 to form a DNA-binding protein complex (the UV-DDB complex); mutations in DDB1 have been linked to Xeroderma pigmentosum. Homo sapiens Accession_evidence: OMIM 600045
          Curator_confirmed: WBPerson324
          Date_last_updated: 07 May 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000174
  Molecular_info: Corresponding_CDS: M18.5
    Corresponding_transcript: M18.5.1
    Other_sequence (25)
    Associated_feature: WBsf652277
      WBsf668398
      WBsf998029
      WBsf1018324
      WBsf1018325
      WBsf230968
      WBsf230969
      WBsf230970
  Experimental_info: RNAi_result: WBRNAi00080767 Inferred_automatically: RNAi_primary
      WBRNAi00077610 Inferred_automatically: RNAi_primary
      WBRNAi00009016 Inferred_automatically: RNAi_primary
      WBRNAi00080751 Inferred_automatically: RNAi_primary
      WBRNAi00025999 Inferred_automatically: RNAi_primary
      WBRNAi00034469 Inferred_automatically: RNAi_primary
      WBRNAi00077608 Inferred_automatically: RNAi_primary
      WBRNAi00080748 Inferred_automatically: RNAi_primary
      WBRNAi00051006 Inferred_automatically: RNAi_primary
      WBRNAi00082407 Inferred_automatically: RNAi_primary
      WBRNAi00112100 Inferred_automatically: RNAi_primary
      WBRNAi00080754 Inferred_automatically: RNAi_primary
      WBRNAi00082676 Inferred_automatically: RNAi_primary
      WBRNAi00080764 Inferred_automatically: RNAi_primary
      WBRNAi00077609 Inferred_automatically: RNAi_primary
      WBRNAi00084870 Inferred_automatically: RNAi_primary
      WBRNAi00080760 Inferred_automatically: RNAi_primary
      WBRNAi00077607 Inferred_automatically: RNAi_primary
      WBRNAi00077606 Inferred_automatically: RNAi_primary
      WBRNAi00071480 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8280
      Expr14902
      Expr1022821
      Expr1034774
      Expr1154715
      Expr2010823
      Expr2029061
    Drives_construct: WBCnstr00013235
      WBCnstr00031076
    Construct_product: WBCnstr00013235
      WBCnstr00031076
    Microarray_results (18)
    Expression_cluster (108)
    Interaction (106)
  Map_info: Map: IV Position: 5.7211 Error: 0.003923
    Positive: Positive_clone: M18 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00010686
    WBPaper00027223
    WBPaper00028040
    WBPaper00028868
    WBPaper00032186
    WBPaper00032472
    WBPaper00032980
    WBPaper00035056
    WBPaper00036109
    WBPaper00038491
    WBPaper00038974
    WBPaper00041771
    WBPaper00042234
    WBPaper00052012
    WBPaper00055090
    WBPaper00056008
    WBPaper00058869
    WBPaper00062469
    WBPaper00063979
    WBPaper00064680
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene