lgl-1 encodes a protein that is related to the Drosophila tumor suppressor Lethal giant larvae (Lgl), a basolateral junction component that regulates cell polarity by controlling localization of proteins to specific regions of the plasma membrane; lgl-1 functions redundantly with par-2 to generate and maintain cell polarity in the early elegans embryo; lgl-1 is involved in the asymmetric partitioning of the PAR (PAR-3/PAR-6/PKC-3) complex most likely by associating with PAR-6 and PKC-3; the association of lgl-1 with the PAR complex is dependent on phosphorylation of lgl-1 by PKC-3; lgl-1 is also required for the proper localization of myosin NMY-2; lgl-1 localizes asymmetrically to the posterior cortex in a PKC-3 dependent manner.
Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Expressed in epithelial cell; intestine; spermathecal cell; and vulval cell. Is an ortholog of human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.