cytb-5.1 encodes a protein orthologous to cytochrome b5; a CYTB-5.1 reporter fusion protein, when expressed in the distal tip cell, exhibits perinuclear localization, consistent with localization to the endoplasmic reticulum.
Predicted to enable heme binding activity. Located in perinuclear region of cytoplasm. Used to study hematopoietic system disease. Human ortholog(s) of this gene implicated in methemoglobinemia; methemoglobinemia and ambiguous genitalia; and stomatitis. Is an ortholog of human CYB5A (cytochrome b5 type A) and CYB5B (cytochrome b5 type B).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.