mog-2 encodes a U2 snRNP protein that functions as a component of a ubiquitous machinery used for the sperm/oocyte switch during hermaphrodite germline development; mog-2 is defined by a single mutation that results in masculinization of the germ line at 25 degrees C, and maternal-effect embryonic and larval lethality at 15 degrees C; genetic epistasis tests indicate that mog-2, like other mog loci, is required for 3'-UTR-mediated repression of the sex determining gene fem-3; in addition, temperature-shift experiments indicate that mog-2 activity is required during the L4 larval stage and into adulthood for normal germline development and throughout adult life for oogenesis; mog-2 not only affects the sperm/oocyte switch in the germ line, but also functions in somatic tissues.
Enables U2 snRNA binding activity. Involved in feminization of hermaphroditic germ-line; germline cell cycle switching, mitotic to meiotic cell cycle; and mRNA 3'-splice site recognition. Located in nucleoplasm. Part of U2 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Is an ortholog of human SNRPA1 (small nuclear ribonucleoprotein polypeptide A').