rsp-4 encodes, along with rsp-5, one of two C. elegans orthologs of the vertebrate SC35 splicing factor and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation.
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); and lung cancer (multiple). Is an ortholog of human SRSF2 (serine and arginine rich splicing factor 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.