WormBase Tree Display for Gene: WBGene00004729
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WBGene00004729 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sax | ||||||
Allele (171) | |||||||
Legacy_information | [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2 | ||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (50) | |||||||
Paralog (22) | |||||||
Structured_description | Concise_description | sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. | Paper_evidence | WBPaper00003665 | |||
WBPaper00004362 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 24 Jan 2008 00:00:00 | ||||||
Automated_description | Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0111797 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||
DOID:3721 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
DOID:0080745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
DOID:10223 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
DOID:9620 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10250) | ||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
DOID:9410 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
DOID:9649 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
EFO:MONDO:0011810 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13433) | ||||
DOID:9538 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
DOID:0060224 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10249) | ||||
Molecular_info | Corresponding_CDS | ZK377.2a | |||||
ZK377.2b | |||||||
Corresponding_CDS_history | ZK377.2c:wp264 | ||||||
Corresponding_transcript | ZK377.2a.1 | ||||||
ZK377.2b.1 | |||||||
Other_sequence (32) | |||||||
Associated_feature (39) | |||||||
Experimental_info | RNAi_result | WBRNAi00086088 | Inferred_automatically | RNAi_primary | |||
WBRNAi00086133 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009468 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009467 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00067130 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059385 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (17) | |||||||
Drives_construct | WBCnstr00001914 | ||||||
WBCnstr00003185 | |||||||
WBCnstr00006455 | |||||||
WBCnstr00009445 | |||||||
WBCnstr00012503 | |||||||
WBCnstr00016209 | |||||||
WBCnstr00035424 | |||||||
WBCnstr00039977 | |||||||
WBCnstr00041184 | |||||||
Construct_product (15) | |||||||
Microarray_results (28) | |||||||
Expression_cluster (134) | |||||||
Interaction (262) | |||||||
Anatomy_function | WBbtf0177 | ||||||
Map_info | Map | X | Position | -10.3398 | Error | 0.007528 | |
Well_ordered | |||||||
Positive | Inside_rearr | mnDp57 | |||||
Positive_clone | R06A1 | ||||||
ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3695 | |||||
3696 | |||||||
4758 | |||||||
Pos_neg_data | 9401 | ||||||
Reference | WBPaper00002991 | ||||||
WBPaper00002997 | |||||||
WBPaper00003665 | |||||||
WBPaper00003674 | |||||||
WBPaper00003760 | |||||||
WBPaper00003949 | |||||||
WBPaper00004362 | |||||||
WBPaper00004695 | |||||||
WBPaper00004900 | |||||||
WBPaper00005236 | |||||||
WBPaper00005237 | |||||||
WBPaper00005251 | |||||||
WBPaper00005544 | |||||||
WBPaper00005719 | |||||||
WBPaper00005760 | |||||||
WBPaper00006025 | |||||||
WBPaper00006052 | |||||||
WBPaper00006185 | |||||||
WBPaper00006288 | |||||||
WBPaper00006471 | |||||||
WBPaper00010168 | |||||||
WBPaper00011128 | |||||||
WBPaper00012380 | |||||||
WBPaper00013450 | |||||||
WBPaper00015626 | |||||||
WBPaper00015717 | |||||||
WBPaper00016704 | |||||||
WBPaper00017099 | |||||||
WBPaper00017383 | |||||||
WBPaper00017429 | |||||||
WBPaper00017433 | |||||||
WBPaper00017704 | |||||||
WBPaper00017711 | |||||||
WBPaper00017712 | |||||||
WBPaper00018333 | |||||||
WBPaper00018335 | |||||||
WBPaper00018572 | |||||||
WBPaper00018582 | |||||||
WBPaper00018588 | |||||||
WBPaper00018942 | |||||||
WBPaper00019306 | |||||||
WBPaper00019311 | |||||||
WBPaper00022845 | |||||||
WBPaper00022847 | |||||||
WBPaper00023013 | |||||||
WBPaper00023085 | |||||||
WBPaper00023161 | |||||||
WBPaper00023199 | |||||||
WBPaper00023310 | |||||||
WBPaper00023315 | |||||||
WBPaper00023401 | |||||||
WBPaper00023980 | |||||||
WBPaper00024140 | |||||||
WBPaper00024195 | |||||||
WBPaper00024484 | |||||||
WBPaper00024524 | |||||||
WBPaper00024525 | |||||||
WBPaper00024722 | |||||||
WBPaper00024939 | |||||||
WBPaper00026115 | |||||||
WBPaper00026148 | |||||||
WBPaper00026343 | |||||||
WBPaper00026416 | |||||||
WBPaper00026439 | |||||||
WBPaper00026680 | |||||||
WBPaper00026825 | |||||||
WBPaper00026845 | |||||||
WBPaper00026866 | |||||||
WBPaper00027119 | |||||||
WBPaper00027206 | |||||||
WBPaper00027335 | |||||||
WBPaper00027618 | |||||||
WBPaper00027646 | |||||||
WBPaper00028085 | |||||||
WBPaper00028566 | |||||||
WBPaper00029024 | |||||||
WBPaper00029052 | |||||||
WBPaper00029053 | |||||||
WBPaper00030317 | |||||||
WBPaper00031043 | |||||||
WBPaper00031067 | |||||||
WBPaper00031543 | |||||||
WBPaper00031651 | |||||||
WBPaper00031671 | |||||||
WBPaper00031828 | |||||||
WBPaper00032413 | |||||||
WBPaper00032446 | |||||||
WBPaper00032941 | |||||||
WBPaper00033533 | |||||||
WBPaper00034526 | |||||||
WBPaper00035405 | |||||||
WBPaper00036313 | |||||||
WBPaper00037014 | |||||||
WBPaper00037766 | |||||||
WBPaper00038491 | |||||||
WBPaper00038504 | |||||||
WBPaper00038663 | |||||||
WBPaper00038670 | |||||||
WBPaper00039166 | |||||||
WBPaper00039177 | |||||||
WBPaper00039204 | |||||||
WBPaper00040041 | |||||||
WBPaper00040048 | |||||||
WBPaper00040235 | |||||||
WBPaper00042082 | |||||||
WBPaper00042510 | |||||||
WBPaper00042766 | |||||||
WBPaper00042977 | |||||||
WBPaper00043290 | |||||||
WBPaper00043374 | |||||||
WBPaper00043453 | |||||||
WBPaper00044158 | |||||||
WBPaper00045899 | |||||||
WBPaper00045955 | |||||||
WBPaper00046690 | |||||||
WBPaper00047484 | |||||||
WBPaper00047772 | |||||||
WBPaper00047944 | |||||||
WBPaper00047958 | |||||||
WBPaper00048281 | |||||||
WBPaper00050480 | |||||||
WBPaper00051142 | |||||||
WBPaper00051935 | |||||||
WBPaper00053739 | |||||||
WBPaper00054187 | |||||||
WBPaper00055090 | |||||||
WBPaper00055566 | |||||||
WBPaper00055911 | |||||||
WBPaper00056066 | |||||||
WBPaper00056135 | |||||||
WBPaper00056294 | |||||||
WBPaper00056384 | |||||||
WBPaper00056692 | |||||||
WBPaper00056744 | |||||||
WBPaper00060014 | |||||||
WBPaper00060641 | |||||||
WBPaper00061219 | |||||||
WBPaper00063298 | |||||||
WBPaper00063743 | |||||||
WBPaper00064099 | |||||||
WBPaper00064636 | |||||||
WBPaper00064805 | |||||||
WBPaper00065184 | |||||||
Remark | Inferred from Zallen et al. (1998) | ||||||
2 predicted genes (see phenotype) have been merged. [sdm 05/00] | |||||||
Method | Gene |