WormBase Tree Display for Gene: WBGene00009813
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WBGene00009813 | SMap | S_parent | Sequence | F47B10 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | haly | |||||
Allele (44) | ||||||
Strain (2) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (13) | ||||||
Ortholog (30) | ||||||
Structured_description | Concise_description | haly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions. | Paper_evidence | WBPaper00031911 | ||
WBPaper00038278 | ||||||
Curator_confirmed | WBPerson1843 | |||||
WBPerson1823 | ||||||
WBPerson567 | ||||||
Date_last_updated | 04 Apr 2011 00:00:00 | |||||
Automated_description | Predicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:0060168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4806) | |
Molecular_info | Corresponding_CDS | F47B10.2 | ||||
Corresponding_transcript | F47B10.2.1 | |||||
Other_sequence | CBC02305_1 | |||||
ACC07520_2 | ||||||
EY466142.1 | ||||||
FC545727.1 | ||||||
EX548375.1 | ||||||
Tcol_isotig08597 | ||||||
JO468853.1 | ||||||
CBC02650_1 | ||||||
EX540054.1 | ||||||
FC543656.1 | ||||||
PTC00961_1 | ||||||
Dviv_isotig14886 | ||||||
SRC03121_1 | ||||||
FC542189.1 | ||||||
EX551231.1 | ||||||
EY470877.1 | ||||||
EY471097.1 | ||||||
EY471600.1 | ||||||
EX014236.1 | ||||||
HGC12030_1 | ||||||
EX565404.1 | ||||||
EX554984.1 | ||||||
ACC28409_1 | ||||||
HBC09534_1 | ||||||
EY458159.1 | ||||||
EX913261.1 | ||||||
Acan_isotig02407 | ||||||
CR07568 | ||||||
EY472009.1 | ||||||
EY467750.1 | ||||||
EY470398.1 | ||||||
EY462049.1 | ||||||
JI167772.1 | ||||||
CJC03221_1 | ||||||
Oden_isotig05930 | ||||||
CRC05094_1 | ||||||
MHC00341_1 | ||||||
Name_isotig00162 | ||||||
EY465596.1 | ||||||
FC540167.1 | ||||||
CR07729 | ||||||
SR02617 | ||||||
ACC07632_1 | ||||||
FC543591.1 | ||||||
EX540759.1 | ||||||
EX544960.1 | ||||||
FC545966.1 | ||||||
ASC13771_1 | ||||||
MH00197 | ||||||
EX542768.1 | ||||||
EX559629.1 | ||||||
FC548845.1 | ||||||
Tcol_isotig08598 | ||||||
EX546639.1 | ||||||
Acan_isotig12730 | ||||||
EX547405.1 | ||||||
EY465182.1 | ||||||
EX537198.1 | ||||||
Name_isotig00161 | ||||||
HG05114 | ||||||
ACC07520_1 | ||||||
FC541446.1 | ||||||
Dviv_isotig14887 | ||||||
EX540247.1 | ||||||
FC544745.1 | ||||||
Acan_isotig02406 | ||||||
EX542922.1 | ||||||
FC542752.1 | ||||||
PT02430 | ||||||
EX559929.1 | ||||||
FC540535.1 | ||||||
EY473282.1 | ||||||
Oden_isotig05929 | ||||||
FC554116.1 | ||||||
ES672549.1 | ||||||
EX540550.1 | ||||||
PT01494 | ||||||
FC547197.1 | ||||||
AS01303 | ||||||
Associated_feature | WBsf654368 | |||||
WBsf237907 | ||||||
WBsf237908 | ||||||
Experimental_info | RNAi_result | WBRNAi00015146 | Inferred_automatically | RNAi_primary | ||
WBRNAi00047595 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00032403 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Chronogram1244 | |||||
Expr6096 | ||||||
Expr1025610 | ||||||
Expr1034288 | ||||||
Expr1151431 | ||||||
Expr2012363 | ||||||
Expr2030599 | ||||||
Drives_construct | WBCnstr00003174 | |||||
WBCnstr00020173 | ||||||
WBCnstr00031899 | ||||||
Construct_product | WBCnstr00020173 | |||||
WBCnstr00031899 | ||||||
Microarray_results (22) | ||||||
Expression_cluster (225) | ||||||
Interaction (19) | ||||||
Map_info | Map | X | Position | 2.67922 | ||
Positive | Positive_clone | F47B10 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Pseudo_map_position | ||||||
Reference | WBPaper00031911 | |||||
WBPaper00038278 | ||||||
WBPaper00038491 | ||||||
WBPaper00039078 | ||||||
WBPaper00045887 | ||||||
WBPaper00055090 | ||||||
WBPaper00063976 | ||||||
WBPaper00064232 | ||||||
WBPaper00065140 | ||||||
WBPaper00065331 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |