WormBase Tree Display for Gene: WBGene00004257
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WBGene00004257 | Evidence | Person_evidence | WBPerson345 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | pxn-2 | Person_evidence | WBPerson345 | |||||
Sequence_name | K09C8.5 | ||||||||
Molecular_name | K09C8.5 | ||||||||
K09C8.5.1 | |||||||||
CE18882 | |||||||||
Other_name | CELE_K09C8.5 | Accession_evidence | NDB | BX284606 | |||||
Public_name | pxn-2 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | pxn | ||||||||
Allele (91) | |||||||||
Strain | WBStrain00050779 | ||||||||
WBStrain00050789 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (24) | |||||||||
Ortholog (47) | |||||||||
Paralog | WBGene00004256 | Caenorhabditis elegans | From_analysis (3) | ||||||
WBGene00015841 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00009897 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00011530 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00019613 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00022743 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00016700 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00019970 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00008627 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00017968 | Caenorhabditis elegans | From_analysis (3) | |||||||
Structured_description | Concise_description | pxn-2 encodes a member of the peroxidasin family of extracellular peroxidases containing several LLRs, two of four Ig domains and a heme peroxidase catalytic domain, PXN-2 is closely related to human PXDN and PXDNL (OMIM: 605158); PXN-2 function becomes critical soon after the twofold stage of epidermal elongation in embryos; pxn-2 mutants display defects in late stages of epidermal elongation, in muscle and epidermal muscle attachments, in vulval muscle attachment and in morphology of adult pharynx; PXN-2 supports a role in basement membrane function and in neuronal development, PXN-2 acts in selective axon guidance decisions but not essential for axon growth; PXN-2 inhibits adult axon regrowth after injury; PXN-1 acts antagonistically to PXN-2; PXN-2 expressed in differentiated epidermal cell throughout embryonic, larval and adult development, in vulval muscles and a few neurons, in longitudinal striations adjacent to the body wall muscle quadrant close to endogenous basement membrane components. | Curator_confirmed | WBPerson12884 | |||||
Date_last_updated | 22 Jun 2011 00:00:00 | ||||||||
Automated_description | Predicted to enable peroxidase activity. Involved in several processes, including embryonic body morphogenesis; muscle attachment; and regulation of cellular component organization. Located in basement membrane. Expressed in PVQL; PVQR; hypodermis; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; asthma (multiple); kidney failure (multiple); and lung disease (multiple). Is an ortholog of human PXDN (peroxidasin) and PXDNL (peroxidasin like). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (21) | ||||||||
Molecular_info | Corresponding_CDS | K09C8.5 | |||||||
Corresponding_transcript | K09C8.5.1 | ||||||||
Other_sequence | Dviv_isotig08472 | ||||||||
Oden_isotig01923 | |||||||||
Oden_isotig01932 | |||||||||
JI165731.1 | |||||||||
Oden_isotig01931 | |||||||||
Oden_isotig01919 | |||||||||
Oden_isotig01911 | |||||||||
DI01593 | |||||||||
Dviv_isotig08475 | |||||||||
Oden_isotig01928 | |||||||||
Oden_isotig01922 | |||||||||
FG355262.1 | |||||||||
Oden_isotig01930 | |||||||||
JO473078.1 | |||||||||
FC553523.1 | |||||||||
Oden_isotig01916 | |||||||||
Oden_isotig01925 | |||||||||
FC542531.1 | |||||||||
Oden_isotig01929 | |||||||||
Oden_isotig01915 | |||||||||
DN152821.1 | |||||||||
JI483385.1 | |||||||||
FC546185.1 | |||||||||
JI480914.1 | |||||||||
Oden_isotig01914 | |||||||||
Tcol_isotig15220 | |||||||||
Oden_isotig01921 | |||||||||
Acan_isotig10163 | |||||||||
Oden_isotig01926 | |||||||||
Oden_isotig01917 | |||||||||
JI474841.1 | |||||||||
Hbac_isotig04421 | |||||||||
HBC18931_1 | |||||||||
Oden_isotig01920 | |||||||||
Oden_isotig01924 | |||||||||
DIC01267_1 | |||||||||
Oden_isotig01908 | |||||||||
Oden_isotig01933 | |||||||||
ACC06446_1 | |||||||||
Tcir_isotig16796 | |||||||||
TM02032 | |||||||||
TMC01784_1 | |||||||||
Oden_isotig01927 | |||||||||
Oden_isotig01910 | |||||||||
Dviv_isotig08474 | |||||||||
PPC19209_1 | |||||||||
Oden_isotig01913 | |||||||||
Oden_isotig01934 | |||||||||
Oden_isotig01918 | |||||||||
Dviv_isotig08473 | |||||||||
Oden_isotig01912 | |||||||||
Oden_isotig01909 | |||||||||
AS10381 | |||||||||
Associated_feature | WBsf1006871 | ||||||||
WBsf237924 | |||||||||
WBsf237925 | |||||||||
Experimental_info | RNAi_result (21) | ||||||||
Expr_pattern | Expr3586 | ||||||||
Expr9134 | |||||||||
Expr9135 | |||||||||
Expr1015080 | |||||||||
Expr1032100 | |||||||||
Expr1154107 | |||||||||
Expr2015201 | |||||||||
Expr2033435 | |||||||||
Drives_construct | WBCnstr00013738 | ||||||||
WBCnstr00013739 | |||||||||
WBCnstr00020278 | |||||||||
WBCnstr00035606 | |||||||||
Construct_product | WBCnstr00011510 | ||||||||
WBCnstr00013739 | |||||||||
WBCnstr00035606 | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (154) | |||||||||
Interaction | WBInteraction000537479 | ||||||||
WBInteraction000537481 | |||||||||
WBInteraction000573516 | |||||||||
Map_info (3) | |||||||||
Reference (17) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |