WormBase Tree Display for Gene: WBGene00003370
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| WBGene00003370 | SMap | S_parent | Sequence | C36E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mlc-2 | Person_evidence | WBPerson21 | |||||
| Sequence_name | C36E6.5 | ||||||||
| Molecular_name | C36E6.5 | ||||||||
| C36E6.5.1 | |||||||||
| CE20542 | |||||||||
| Other_name | CELE_C36E6.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mlc-2 | ||||||||
| DB_info | Database | AceView | gene | XS70 | |||||
| WormQTL | gene | WBGene00003370 | |||||||
| WormFlux | gene | WBGene00003370 | |||||||
| NDB | locus_tag | CELE_C36E6.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003370|UniProtKB=P19626 | |||||||
| family | PTHR23049 | ||||||||
| NCBI | gene | 181775 | |||||||
| RefSeq | protein | NM_078427.10 | |||||||
| SwissProt | UniProtAcc | P19626 | |||||||
| UniProt_GCRP | UniProtAcc | P19626 | |||||||
| OMIM | gene | 160781 | |||||||
| 617378 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mlc | ||||||||
| Allele (24) | |||||||||
| Legacy_information | [C.elegansII] Deletion exhibits pharyngeal pumping defect,10% reach fertile adulthood (most males reach adulthood). Deletion of both mlc-1 and mlc-2 leads to lethal arrest as short lumpy paralysed L1/L2. Resembles mammalian non-muscle MLC; expressed in both pharynx and body wall; SL1transpliced. [Cummins and Anderson 1988; Rushforth et al. 1993; TR] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (72) | |||||||||
| Paralog | WBGene00003369 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003372 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mlc-2 encodes, along with mlc-1 and mlc-4, one of three C. elegans regulatory myosin light chains; MLC-2 is predicted to function as a regulator of myosin ATPase activity, and genetic studies indicate that MLC-2 is nearly essential in hermaphrodites for normal pharyngeal muscle function, but redundant with MLC-1, with which it is nearly identical, for proper bodywall muscle development; accordingly, loss of mlc-2 activity eventually results in larval lethality, as animals are not able to feed properly; mlc-2 mRNA is expressed in bodywall, pharyngeal, and vulval muscles. | Paper_evidence | WBPaper00003259 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Oct 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable myosin heavy chain binding activity. Involved in several processes, including nematode larval development; regulation of muscle contraction; and regulation of pharyngeal pumping. Predicted to be located in cytoplasm. Predicted to be part of myosin II complex. Expressed in body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29824) | ||||
| DOID:0110316 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
| DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
| Molecular_info | Corresponding_CDS | C36E6.5 | |||||||
| Corresponding_transcript | C36E6.5.1 | ||||||||
| Other_sequence | BMC15781_1 | ||||||||
| DAC00873_1 | |||||||||
| BE217643.1 | |||||||||
| CV200346.1 | |||||||||
| MAC00115_1 | |||||||||
| AM744425.1 | |||||||||
| MJC01499_1 | |||||||||
| OVC01296_1 | |||||||||
| CBC05287_1 | |||||||||
| MHC06538_1 | |||||||||
| FJ039850.1 | |||||||||
| AI130592.1 | |||||||||
| RS06057 | |||||||||
| CRC03294_1 | |||||||||
| MIC00058_2 | |||||||||
| CJC01295_1 | |||||||||
| ACC28766_1 | |||||||||
| SRC00712_1 | |||||||||
| MHC00135_1 | |||||||||
| AI130183.1 | |||||||||
| AF402308.1 | |||||||||
| DA00150 | |||||||||
| MJ00748 | |||||||||
| EL888052.1 | |||||||||
| FG350999.1 | |||||||||
| HG03499 | |||||||||
| NBC00287_1 | |||||||||
| BU086946.1 | |||||||||
| MI02479 | |||||||||
| GR978122.1 | |||||||||
| BMC03445_1 | |||||||||
| AI124223.1 | |||||||||
| XI01340 | |||||||||
| MI01024 | |||||||||
| GR14884 | |||||||||
| EX552109.1 | |||||||||
| PPC00678_1 | |||||||||
| DIC01134_1 | |||||||||
| AI374073.1 | |||||||||
| MA00485 | |||||||||
| CJC01750_1 | |||||||||
| EX551685.1 | |||||||||
| MIC01660_1 | |||||||||
| CV199029.1 | |||||||||
| BM00330 | |||||||||
| DI01918 | |||||||||
| ACC19879_1 | |||||||||
| MPC00111_1 | |||||||||
| NB07211 | |||||||||
| WBC02099_1 | |||||||||
| PP01690 | |||||||||
| FC816986.1 | |||||||||
| PT04156 | |||||||||
| CN477497.1 | |||||||||
| MA00563 | |||||||||
| MP00662 | |||||||||
| MHC08115_1 | |||||||||
| GO253110.1 | |||||||||
| PT00565 | |||||||||
| Tcir_isotig08551 | |||||||||
| RSC01826_1 | |||||||||
| BE225557.1 | |||||||||
| SC00020 | |||||||||
| FG355495.1 | |||||||||
| FG352770.1 | |||||||||
| MH09772 | |||||||||
| ACC01257_1 | |||||||||
| ACC01289_1 | |||||||||
| CB043242.1 | |||||||||
| Acan_isotig13276 | |||||||||
| PTC03535_1 | |||||||||
| BM01472 | |||||||||
| GO250243.1 | |||||||||
| CJC00225_1 | |||||||||
| PVC01061_1 | |||||||||
| AW562132.1 | |||||||||
| EL888902.1 | |||||||||
| GR978765.1 | |||||||||
| MI03312 | |||||||||
| HC02016 | |||||||||
| XIC00084_1 | |||||||||
| FC554201.1 | |||||||||
| MHC11894_1 | |||||||||
| MA00544 | |||||||||
| SRC07549_1 | |||||||||
| XI01113 | |||||||||
| AW257756.1 | |||||||||
| MP00408 | |||||||||
| PVC00103_1 | |||||||||
| AYC03532_1 | |||||||||
| CK855245.1 | |||||||||
| AE02813 | |||||||||
| XI01819 | |||||||||
| CK850853.1 | |||||||||
| Tcol_isotig06708 | |||||||||
| BE239038.1 | |||||||||
| CV199408.1 | |||||||||
| MI03143 | |||||||||
| MH02740 | |||||||||
| CN477544.1 | |||||||||
| FG586657.1 | |||||||||
| PTC03229_1 | |||||||||
| MAC00115_2 | |||||||||
| EX554267.1 | |||||||||
| MJ00605 | |||||||||
| Oden_isotig01005 | |||||||||
| CR02473 | |||||||||
| SS01418 | |||||||||
| CBC01828_1 | |||||||||
| SR00998 | |||||||||
| XIC00135_1 | |||||||||
| MJ00792 | |||||||||
| CK855409.1 | |||||||||
| HGC00256_1 | |||||||||
| MIC00058_1 | |||||||||
| EX560764.1 | |||||||||
| FC817010.1 | |||||||||
| MI02526 | |||||||||
| HO652283.1 | |||||||||
| EW742011.1 | |||||||||
| MJ02440 | |||||||||
| MI02591 | |||||||||
| HCC00313_1 | |||||||||
| ES413019.1 | |||||||||
| NAC01126_1 | |||||||||
| MJC00965_1 | |||||||||
| CV200245.1 | |||||||||
| AA668110.1 | |||||||||
| EX541033.1 | |||||||||
| OOC03104_1 | |||||||||
| PTC01255_1 | |||||||||
| FG354603.1 | |||||||||
| MH07161 | |||||||||
| PVC01142_1 | |||||||||
| CA994367.1 | |||||||||
| MI00882 | |||||||||
| JI474442.1 | |||||||||
| GR14885 | |||||||||
| GR11533 | |||||||||
| Acan_isotig11690 | |||||||||
| Associated_feature | WBsf654741 | ||||||||
| WBsf1008927 | |||||||||
| WBsf1025040 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr2737 | ||||||||
| Expr4001 | |||||||||
| Expr1031549 | |||||||||
| Expr1146072 | |||||||||
| Expr2013590 | |||||||||
| Expr2031823 | |||||||||
| Drives_construct | WBCnstr00036155 | ||||||||
| WBCnstr00041971 | |||||||||
| WBCnstr00041982 | |||||||||
| WBCnstr00042092 | |||||||||
| Construct_product | WBCnstr00036155 | ||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (231) | |||||||||
| Interaction (39) | |||||||||
| Map_info | Map | X | Position | 24.1039 | Error | 0.002498 | |||
| Positive | Positive_clone | C36E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZK54 | |||||||||
| Mapping_data | Pos_neg_data (7) | ||||||||
| Reference (32) | |||||||||
| Remark | blastN of whole EMBL sequence to genomic canonical gives 100% match to C36E6.b. sdm 12/00 | ||||||||
| C36E6.b changed to .5 [sdm 0103] | |||||||||
| Method | Gene |
