WormBase Tree Display for Gene: WBGene00002008
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| WBGene00002008 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-4 | Person_evidence | WBPerson36 | |||||
| Sequence_name | F43E2.8 | ||||||||
| Molecular_name | F43E2.8a | ||||||||
| F43E2.8a.1 | |||||||||
| CE07244 | |||||||||
| F43E2.8b | |||||||||
| CE49318 | |||||||||
| F43E2.8a.2 | |||||||||
| F43E2.8b.1 | |||||||||
| Other_name | hsp70er2 | Paper_evidence | WBPaper00064398 | ||||||
| CELE_F43E2.8 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | hsp-4 | ||||||||
| DB_info | Database | AceView | gene | 2H640 | |||||
| WormQTL | gene | WBGene00002008 | |||||||
| WormFlux | gene | WBGene00002008 | |||||||
| NDB | locus_tag | CELE_F43E2.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002008|UniProtKB=P20163 | |||||||
| family | PTHR19375 | ||||||||
| NCBI | gene | 174203 | |||||||
| RefSeq | protein | NM_001383885.2 | |||||||
| NM_001306541.3 | |||||||||
| SwissProt | UniProtAcc | P20163 | |||||||
| TrEMBL | UniProtAcc | V6CL98 | |||||||
| UniProt_GCRP | UniProtAcc | P20163 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele (28) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes protein related to mammalian grp78/BiP; strongly induced by heat shock. [Heschl and Baillie 1990; BC] | ||||||||
| Strain | WBStrain00036323 | ||||||||
| WBStrain00051694 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (50) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | hsp-4 encodes one of two C. elegans heat shock response 70 (hsp70) proteins homologous to mammalian grp78/BiP (glucose regulated protein 78/immunoglobulin heavy chain-binding protein, OMIM:138120); hsp-4 affects embryonic and larval viability; hsp-4 is expressed in several tissues including the hypodermis, intestine, and spermatheca; hsp-4 transcription is upregulated in response to endoplasmic reticulum stress induced by dithiothreitol (DTT) or tunicamycin (unfolded protein response) as well as in response to heat shock and treatment of animals with pore-forming toxins such as Cry5B. | Paper_evidence | WBPaper00001136 | |||||
| WBPaper00001320 | |||||||||
| WBPaper00005036 | |||||||||
| WBPaper00005044 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00024269 | |||||||||
| WBPaper00031857 | |||||||||
| WBPaper00032255 | |||||||||
| WBPaper00005432 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 25 Oct 2013 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in endoplasmic reticulum unfolded protein response. Located in rough endoplasmic reticulum. Expressed in PVDL; PVDR; intestinal muscle; and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including dopamine beta-hydroxylase deficiency; inflammatory bowel disease; and rheumatoid arthritis. Is an ortholog of human HSPA5 (heat shock protein family A (Hsp70) member 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||
| DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||||
| DOID:0090145 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||||
| DOID:0050589 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||||
| Molecular_info | Corresponding_CDS (2) | ||||||||
| Corresponding_transcript | F43E2.8a.1 | ||||||||
| F43E2.8a.2 | |||||||||
| F43E2.8b.1 | |||||||||
| Other_sequence | EY461279.1 | ||||||||
| HGC09672_1 | |||||||||
| BUC01616_1 | |||||||||
| MI01698 | |||||||||
| CB832545.1 | |||||||||
| BI772817.1 | |||||||||
| EX009349.1 | |||||||||
| BI772862.1 | |||||||||
| BI772830.1 | |||||||||
| FK670248.1 | |||||||||
| XI03587 | |||||||||
| MI04634 | |||||||||
| CR11369 | |||||||||
| MIC03336_1 | |||||||||
| JI257344.1 | |||||||||
| EX500270.1 | |||||||||
| BMC03541_1 | |||||||||
| BI772867.1 | |||||||||
| CRC04758_1 | |||||||||
| MIC01158_1 | |||||||||
| CRC04218_1 | |||||||||
| CBC01428_1 | |||||||||
| FG976216.1 | |||||||||
| MI04290 | |||||||||
| HG08099 | |||||||||
| CR02729 | |||||||||
| CR02737 | |||||||||
| BI773082.1 | |||||||||
| MIC04046_1 | |||||||||
| CRC12426_1 | |||||||||
| TSC01300_1 | |||||||||
| DN153405.1 | |||||||||
| BI772978.1 | |||||||||
| MHC07064_1 | |||||||||
| FG618923.1 | |||||||||
| NB12183 | |||||||||
| HG04877 | |||||||||
| MH01409 | |||||||||
| MI05525 | |||||||||
| MHC00434_1 | |||||||||
| ES739701.1 | |||||||||
| HG10507 | |||||||||
| CGC00977_1 | |||||||||
| CBC08973_1 | |||||||||
| Associated_feature | WBsf650221 | ||||||||
| WBsf650222 | |||||||||
| WBsf650223 | |||||||||
| WBsf665682 | |||||||||
| WBsf665683 | |||||||||
| WBsf988418 | |||||||||
| WBsf1012519 | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00002743 | ||||||||
| WBCnstr00005157 | |||||||||
| WBCnstr00009660 | |||||||||
| WBCnstr00013152 | |||||||||
| WBCnstr00014616 | |||||||||
| WBCnstr00016655 | |||||||||
| WBCnstr00018297 | |||||||||
| WBCnstr00020788 | |||||||||
| WBCnstr00036525 | |||||||||
| Construct_product | WBCnstr00020788 | ||||||||
| WBCnstr00036525 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (233) | |||||||||
| Interaction (399) | |||||||||
| WBProcess | WBbiopr:00000046 | ||||||||
| WBbiopr:00000076 | |||||||||
| WBbiopr:00000079 | |||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | II | Position | 0.502202 | Error | 0.000194 | |||
| Positive | Positive_clone | F43E2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5625 | |||||||
| 4390 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (124) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
