WormBase Tree Display for Gene: WBGene00002007

WBGene00002007 SMap: S_parent: Sequence: C15H9
  Identity: Version: 1
    Name: CGC_name: hsp-3 Person_evidence: WBPerson36
      Sequence_name: C15H9.6
      Molecular_name (7)
      Other_name: hsp70er1 Paper_evidence: WBPaper00064398
        CELE_C15H9.6 Accession_evidence: NDB BX284606
      Public_name: hsp-3
    DB_info: Database: AceView gene XG708
        WormQTL gene WBGene00002007
        WormFlux gene WBGene00002007
        NDB locus_tag CELE_C15H9.6
        Panther gene CAEEL|WormBase=WBGene00002007|UniProtKB=P27420
          family PTHR19375
        NCBI gene 180880
        RefSeq protein NM_001383595.2
            NM_001307849.4
        SwissProt UniProtAcc P27420
        TrEMBL UniProtAcc V6CJ24
        UniProt_GCRP UniProtAcc P27420
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsp
    Allele (57)
    Legacy_information: [C.elegansII] NMK. Encodes protein related to mammalian grp78/BiP; not heat shock induced. [Heschl and Baillie 1990; BC]
    Strain: WBStrain00031808
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (53)
    Paralog (11)
    Structured_description: Concise_description: hsp-3 encodes one of two C. elegans heat shock response 70 (hsp70) proteins homologous to mammalian grp78/BiP (glucose regulated protein 78/immunoglobulin heavy chain-binding protein, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; hsp-3 transcription is, however, upregulated in response to endoplasmic reticulum stress induced by dithiothreitol (DTT) or tunicamycin; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. Paper_evidence: WBPaper00001136
            WBPaper00001320
            WBPaper00005044
            WBPaper00031857
          Curator_confirmed: WBPerson1843
          Date_last_updated: 25 Aug 2010 00:00:00
      Automated_description: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen; membrane; and nucleus. Predicted to be part of endoplasmic reticulum chaperone complex. Expressed in several structures, including germ line; hypodermis; intestinal muscle; pharyngeal-intestinal valve; and tail. Human ortholog(s) of this gene implicated in several diseases, including dopamine beta-hydroxylase deficiency; inflammatory bowel disease; and rheumatoid arthritis. Is an ortholog of human HSPA5 (heat shock protein family A (Hsp70) member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
      DOID:3070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
      DOID:0090145 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
      DOID:0050589 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
  Molecular_info: Corresponding_CDS: C15H9.6a
      C15H9.6b
    Corresponding_transcript: C15H9.6a.1
      C15H9.6a.2
      C15H9.6b.1
    Other_sequence: EX911356.1
      JI174606.1
      FK800466.1
      GO251686.1
      FC812027.1
      FG589297.1
      PVC00742_1
      EW741816.1
      FK800615.1
      MIC03801_1
      AYC02115_1
      TCC01561_1
      CR10889
      HG01779
      PP00471
      FG589236.1
      HGC02222_1
      ASC01968_1
      AS01098
      TX01590
      BU586702.1
      BUC00823_1
      Oden_isotig13782
      MH09025
      SS01231
      CJC01613_1
      EX013215.1
      HS01114
      Dviv_isotig10310
      EX542535.1
      JK315309.1
      FG979474.1
      FG589082.1
      AYC02456_1
      AE04413
      FG978892.1
      FG971926.1
      AE04052
      FK801501.1
      ES568223.1
      FG584385.1
      FG974210.1
      HM017959.1
      TSC08876_1
      FG978128.1
      FG979935.1
      HCC09767_1
      SR00065
      BI772834.1
      FD515529.1
      BI773150.1
      PT02556
      EX008661.1
      FK804924.1
      OOC02256_1
      FG974308.1
      FG976350.1
      ES568233.1
      FK670256.1
      AE04391
      FK800906.1
      GO250439.1
      EX912415.1
      EX559693.1
      FG976470.1
      EY470559.1
      PPC04320_1
      JI169440.1
      FK804088.1
      ASC00835_1
      HBC01405_1
      Oden_isotig13869
      Tcir_isotig16917
      EY467796.1
      EW742619.1
      GR19730
      ES411622.1
      BXC02785_1
      FF680339.1
      EX553301.1
      FK801917.1
      FC544391.1
      HGC09557_1
      BI772966.1
      FC820501.1
      MJC02836_1
      Acan_isotig21341
      EX554913.1
      CSC00921_1
      AF529194.1
      AY046874.2
      CR04283
      MJ00380
      FG589352.1
      SSC00248_1
      FC539991.1
      FC817632.1
      ES880203.1
      CRC00263_1
      CR09480
      AY137471.1
      CR08757
      PPC00441_1
      AE00253
      HBC00250_1
      XI00804
      EX541265.1
      EW741429.1
      FG580575.1
      FK805755.1
      JO467943.1
      HC04659
      BI772931.1
      FF680407.1
      Tcol_isotig14769
      XI00971
      EX560495.1
      MHC01853_1
      FK802235.1
      FG980022.1
      EV852653.1
      NBC09725_1
      NB08276
      SRC02712_2
      FG973577.1
      EV851568.1
      MH01619
      Tcol_isotig18142
      ASC31931_1
      ACC04164_1
      BI773075.1
      GP02110
      FK800639.1
      ES568220.1
      EW744637.1
      CJC01644_1
      FC810330.1
      FC545641.1
      SR00404
      CBC02263_1
      SSC06169_1
      FG978169.1
      AE00644
      ACC01083_1
      FK801856.1
      FK809332.1
      MIC03334_1
      FM207833.1
      EX545904.1
      FC547038.1
      EX563953.1
      FE913600.1
      EX010210.1
      SSC00248_2
      Tcol_isotig03472
      FG977320.1
      Oden_isotig13781
      FG974598.1
      EW743645.1
      AYC03712_1
      HG03466
      FK803451.1
      FE906542.1
      ES413753.1
      MHC07040_1
      Tcol_isotig03473
      Name_isotig06192
      BI773015.1
      Tcir_isotig05576
      EX010199.1
      Oden_isotig28608
      FC818409.1
      Acan_isotig06738
      FC814438.1
      ACC04260_1
      DVC00581_1
      EY466117.1
      FG975845.1
      BI773004.1
      EX915407.1
      JI216834.1
      HC05568
      Tcir_isotig08009
      ES740062.1
      FK806540.1
      AS04093
      TCC02004_1
      Oden_isotig13870
      ES568251.1
      MI04633
      SRC09204_1
      SRC02712_1
      EX827612.1
      GPC03177_1
      CR12152
      CR09707
      CRC02569_1
      BI772863.1
      EL890738.1
      FC554593.1
      EX554133.1
      BI773108.1
      BXC02150_1
      SR05108
      BI773163.1
      ACC11651_1
      GR17278
      FK806324.1
      ALC00818_1
      SS01052
      Hbac_isotig00186
      NBC00009_1
      Tcol_isotig17668
      FG580497.1
      FK805556.1
      EX562096.1
      PTC00910_1
      ACC08040_1
      FC815721.1
      AS02395
      Acan_isotig08381
      EX545373.1
      BI772994.1
      Name_isotig05303
      MH09015
      PT00727
      CRC00422_1
      FG619040.1
      ACC05849_1
      EX565110.1
      Dviv_isotig10309
      EX011316.1
      CR02750
      EX558659.1
      XIC00114_1
      JI178180.1
      AYC02747_1
      FG974646.1
      FG583320.1
      SR03695
      EX566651.1
      EX551962.1
      GR11943
      FC819003.1
      FF680098.1
      AAC00380_1
      DN190629.1
      HCC07330_1
      ES570542.1
      Oden_isotig13868
      BI772840.1
      MI02303
      FC812741.1
      FG974515.1
      TLC00185_1
      CBC03048_1
      Oden_isotig23133
      Acan_isotig02714
      FK806783.1
      SSC01310_1
      Tcir_isotig12264
      BI772889.1
      TX01471
      FG979363.1
      TSC07456_1
      FG976408.1
      JK315142.1
      SRC02116_1
      HG06797
      GO250269.1
      Name_isotig01196
      HBC05660_1
      ACC16066_1
      ES739162.1
      CGC01243_1
      FG972699.1
      JI245367.1
      GRC00639_1
      Dviv_isotig10311
      Acan_isotig02713
    Associated_feature (25)
  Experimental_info: RNAi_result (31)
    Expr_pattern (11)
    Drives_construct: WBCnstr00002023
      WBCnstr00002024
      WBCnstr00009609
      WBCnstr00015264
      WBCnstr00019129
      WBCnstr00036526
    Construct_product: WBCnstr00036526
    Microarray_results (28)
    Expression_cluster (247)
    Interaction (318)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000046
      WBbiopr:00000079
  Map_info: Map: X Position: -3.73772 Error: 0.017656
    Positive: Positive_clone: BC#HS148
        C15H9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4344
        4540
    Pseudo_map_position
  Reference (46)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene