[C.elegansII] NMK. Sequence predicts protein with closer similarity to vertebrate cytoplasmic actin than act-123, act-4. act-5:lacZ expressed only in microvillous intestinal cells and excretory cell. [RW]
act-5 encodes an ortholog of human cytoplasmic actin; act-5 is required for formation of the terminal web and microvilli on the apical surface of intestinal cells; act-5 also plays a role in mediating non-lytic exit of intracellular parasites from the intestine; act-5 is expressed only in intestinal cells and in the excretory cell; in the intestine, ACT-5 localizes to microvilli and the terminal web.
Involved in several processes, including larval feeding behavior; microvillus assembly; and positive regulation of eating behavior. Located in microvillar actin bundle and terminal web. Expressed in excretory cell; gonad; intestine; pharyngeal-intestinal valve; and rectal gland cell.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.