eol-1 encodes a homolog of vertebrate DXO/Dom3Z, a decapping and exoribonuclease protein that functions in pre-mRNA quality control; in C. elegans, EOL-1 activity is required in the URX sensory neurons for inhibition of olfactory learning; mouse Dom3Z can functionally substitute for C. elegans EOL-1, demonstrating conservation of activity for these proteins; in adult hermaphrodites, an eol-1::gfp promoter fusion is expressed in several head and tail neurons, including URX, AVF, and PQR, and in reproductive tissues.
Predicted to enable 5'-3' exonuclease activity; mRNA 5'-diphosphatase activity; and mRNA binding activity. Involved in regulation of olfactory learning. Predicted to be located in cytosol and nucleus. Expressed in AVF; oxygen sensory neurons; and reproductive system.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.