WormBase Tree Display for Gene: WBGene00011734

WBGene00011734 SMap: S_parent: Sequence: T12D8
  Identity: Version: 2
    Name: CGC_name: mlc-5 Paper_evidence: WBPaper00035085
          Person_evidence: WBPerson21
      Sequence_name: T12D8.6
      Molecular_name: T12D8.6
        T12D8.6.1
        CE16403
      Other_name: CELE_T12D8.6 Accession_evidence: NDB BX284603
      Public_name: mlc-5
    DB_info: Database: AceView gene 3O713
        WormQTL gene WBGene00011734
        WormFlux gene WBGene00011734
        NDB locus_tag CELE_T12D8.6
        Panther gene CAEEL|WormBase=WBGene00011734|UniProtKB=Q9XVI9
          family PTHR23048
        NCBI gene 176796
        RefSeq protein NM_067412.10
        SwissProt UniProtAcc Q9XVI9
        UniProt_GCRP UniProtAcc Q9XVI9
        OMIM gene 160770
            160780
            160790
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 26 Jul 2011 11:53:04 WBPerson2970 Name_change: CGC_name: mlc-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mlc
    Allele (23)
    Strain: WBStrain00003504
      WBStrain00049410
    RNASeq_FPKM (74)
    GO_annotation (11)
    Contained_in_operon: CEOP3816
    Ortholog: WBGene00037703 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00055879 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00141138 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00210819 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00161503 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00215393 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00078758 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00226006 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g5385 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11917 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1717 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13695 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3617 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g21083 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4889 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g13982 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g5063 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g13213 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00316.g9071 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_III.g9714 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold628.g7232 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00269.g8368 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_18173 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_010347 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09414 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g19141 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30105200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g9394 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00123812 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00244357 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258931 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00265765 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286972 Trichuris muris From_analysis: WormBase-Compara
      WBGene00291461 Trichuris muris From_analysis: WormBase-Compara
      WBGene00302707 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003074 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0004687 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000322-6 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030522-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-8109 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-9170 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1593 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050626-112 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-041010-28 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070410-135 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7582 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7584 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7585 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7587 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:29823 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:97267 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:97268 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:97269 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:109318 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1917789 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:3142 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1598796 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1305620 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1589019 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1591197 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:41207417 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00003371 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009585 Caenorhabditis elegans From_analysis: Panther
      WBGene00010554 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00023451 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mlc-5 encodes a protein containing two EF-hand domains that is the C. elegans myosin II essential light chain ortholog; MLC-5 activity is required for cytokinesis and for epithelial morphogenesis during embryonic elongation; a GFP::MLC-5 fusion protein is expressed during embryogenesis in the lateral hypodermal seam cells as well as in the dorsal and ventral hypodermal cells where it exhibits co-localization with actin bundles; MLC-5 subcellular localization depends upon activity of MLC-4, a myosin regulatory light chain; in turn, MLC-5 activity is required for proper localization of MLC-4 and the non-muscle myosin II NMY-2. Paper_evidence: WBPaper00035085
          Curator_confirmed: WBPerson1843
          Date_last_updated: 06 Sep 2011 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081346 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7582)
      DOID:0050650 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7585)
      DOID:0050700 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7585)
      DOID:0110314 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7584)
  Molecular_info: Corresponding_CDS: T12D8.6
    Corresponding_transcript: T12D8.6.1
    Other_sequence (97)
    Associated_feature: WBsf645723
      WBsf645724
      WBsf654994
      WBsf226038
      WBsf226039
      WBsf226040
      WBsf226041
  Experimental_info: RNAi_result (11)
    Expr_pattern (7)
    Drives_construct: WBCnstr00003962
      WBCnstr00030430
    Construct_product: WBCnstr00030430
    Microarray_results (21)
    Expression_cluster (110)
    Interaction (28)
  Map_info: Map: III Position: 21.2981 Error: 0.001406
    Positive: Positive_clone: T12D8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00024200
    WBPaper00035085
    WBPaper00035228
    WBPaper00038491
    WBPaper00040157
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene