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WormBase Tree Display for Gene: WBGene00007054

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WBGene00007054	SMap	S_parent	Sequence	B0379
	Identity	Version	3
		Name	CGC_name	scpl-1	Person_evidence	WBPerson56
			Sequence_name	B0379.4
			Molecular_name (9)
			Other_name	tag-188	Person_evidence	WBPerson201
				CELE_B0379.4	Accession_evidence	NDB	BX284601
			Public_name	scpl-1
		DB_info	Database (12)
		Species	Caenorhabditis elegans
		History	Version_change	1	26 May 2004 13:09:06	WBPerson1845	Event	Created
				2	05 Oct 2005 17:16:53	WBPerson2970	Event	Acquires_merge	WBGene00007157
							Name_change	Sequence_name	B0379.4
				3	02 Feb 2007 10:26:41	WBPerson2970	Name_change	CGC_name	scpl-1
								Other_name	tag-188
			Acquires_merge	WBGene00007157
				WBGene00043085
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	scpl
		Allele (181)
		Strain	WBStrain00031805
			WBStrain00035918
		RNASeq_FPKM (74)
		GO_annotation (22)
		Ortholog	WBGene00057236	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00026641	Caenorhabditis briggsae	From_analysis	Hillier-set
						OrthoMCL
						OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00157271	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00164323	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00120562	Caenorhabditis japonica	From_analysis	TreeFam
						WormBase-Compara
			WBGene00222043	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g12343	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g11973	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g7265	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g7879	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g4894	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g3576	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g17221	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g13314	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g4843	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g19776	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_00066.g3215	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-scpl-1	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold629.g15231	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00870.g16294	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_17564	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_000760	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g05899	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g14129	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_10180910	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrI_pilon.g1966	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00237815	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00113633	Pristionchus pacificus	From_analysis	WormBase-Compara
			WBGene00260467	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00285367	Trichuris muris	From_analysis	WormBase-Compara
			SGD:S000003933	Saccharomyces cerevisiae	From_analysis	Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			SGD:S000004009	Saccharomyces cerevisiae	From_analysis	Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			FB:FBgn0036556	Drosophila melanogaster	From_analysis	Hieranoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-030131-184	Danio rerio	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						SonicParanoid
			ZFIN:ZDB-GENE-050522-523	Danio rerio	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-060825-333	Danio rerio	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-060929-488	Danio rerio	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:17077	Homo sapiens	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						SonicParanoid
			HGNC:16890	Homo sapiens	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:21614	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			MGI:1098748	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						SonicParanoid
			MGI:1916524	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			MGI:2654470	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:1305629	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			RGD:2319209	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						SonicParanoid
		Paralog	WBGene00021629	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00011897	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00018474	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	scpl-1 encodes, by alternative splicing, two protein isoforms of a putative class-C RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) phosphatase, orthologous to budding yeast PSR1 and PSR2 and human CTDSP1 (OMIM:605323), CTDSP2 (OMIM:608711, amplified in sarcoma), and CTDSPL (OMIM:608592, deleted in epithelial cancer), and paralogous to C. elegans SCPL-3 and human CTDSPL2; more distantly, SCPL-1 (and its paralog SCPL-3) are similar to SCPL-2, SCPL-4, and FCP-1; loss of scpl-1 activity via RNAi results in a slightly abnormal egg-laying response in the presence of serotonin; an scpl-1::gfp promoter fusion is expressed in pharyngeal, vulval, and body wall muscle; within body wall muscle, SCPL-1 localize to the M line and I band; SCPL-1 physically interacts with UNC-89 both in vitro and in vivo.	Paper_evidence	WBPaper00029277
						WBPaper00029278
						WBPaper00029279
						WBPaper00029280
						WBPaper00031595
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	16 Dec 2011 00:00:00
			Automated_description	Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:3908	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:16890)
	Molecular_info	Corresponding_CDS	B0379.4a
			B0379.4b
			B0379.4c
		Corresponding_CDS_history	B0379.4:wp77
			B0379.4a:wp103
			B0379.4b:wp103
		Corresponding_transcript	B0379.4a.1
			B0379.4b.1
			B0379.4c.1
		Other_sequence (38)
		Associated_feature (22)
		Transcription_factor	WBTranscriptionFactor000636
	Experimental_info	RNAi_result (13)
		Expr_pattern	Chronogram589
			Expr8052
			Expr8053
			Expr1015780
			Expr1033029
			Expr1143160
			Expr2015647
			Expr2033879
		Drives_construct	WBCnstr00002821
			WBCnstr00013080
		Antibody	WBAntibody00001386
			WBAntibody00001387
		Microarray_results (25)
		Expression_cluster (94)
		Interaction (39)
	Map_info	Map	I	Position	4.63311	Error	0.019017
		Positive	Positive_clone	B0379	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	5541
				5251
		Pseudo_map_position
	Reference (11)
	Remark	tag-188 is parsed from CGC strain VC612
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene