Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006959

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006959SMapS_parentSequenceR74
IdentityVersion1
NameCGC_namexbp-1Person_evidenceWBPerson159
Sequence_nameR74.3
Molecular_nameR74.3
R74.3.1
CE40514
R74.3.2
Other_nameCELE_R74.3Accession_evidenceNDBBX284603
Public_namexbp-1
DB_infoDatabaseWormQTLgeneWBGene00006959
WormFluxgeneWBGene00006959
NDBlocus_tagCELE_R74.3
PanthergeneCAEEL|WormBase=WBGene00006959|UniProtKB=A0FLQ8
familyPTHR46542
NCBIgene175541
RefSeqproteinNM_001083177.4
SwissProtUniProtAccG5EE07
UniProt_GCRPUniProtAccG5EE07
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:44WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classxbp
Allele (18)
Possibly_affected_byWBVar02153517
WBVar02153518
WBVar02153519
StrainWBStrain00034061
RNASeq_FPKM (74)
GO_annotation (37)
Contained_in_operonCEOP3865
OrthologWBGene00070968Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00039220Caenorhabditis briggsaeFrom_analysisOrthoMCL
Inparanoid_8
WormBase-Compara
WBGene00145829Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00130300Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00225670Brugia malayiFrom_analysisWormBase-Compara
CSP26.g11276Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g5377Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g1349Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP32.g3948Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g3788Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP40.g9848Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-xbp-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g11494Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_04511.g33111Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_07268Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_008914Caenorhabditis remaneiFrom_analysisWormBase-Compara
Sp34_30029000Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g7393Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00244432Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00104964Pristionchus pacificusFrom_analysisWormBase-Compara
FB:FBgn0021872Drosophila melanogasterFrom_analysisOrthoFinder
OrthoInspector
Panther
ZFIN:ZDB-GENE-011210-2Danio rerioFrom_analysisOrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:12801Homo sapiensFrom_analysisOrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:98970Mus musculusFrom_analysisOrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1303073Rattus norvegicusFrom_analysisOrthoFinder
OrthoInspector
Panther
SonicParanoid
Structured_descriptionConcise_descriptionxbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); xbp-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development; loss of xbp-1 activity also results in near-complete loss of myo-2 pharnygeal myosin expression, although pharyngeal muscle is still present.Paper_evidence (5)
Curator_confirmedWBPerson1843
Date_last_updated16 Nov 2011 00:00:00
Automated_descriptionEnables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; determination of adult lifespan; and response to endoplasmic reticulum stress. Predicted to be located in nucleus. Expressed widely. Is an ortholog of human XBP1 (X-box binding protein 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Modifies_diseaseDOID:10652
Modifies_disease_in_annotationWBDOannot00000237
Molecular_infoCorresponding_CDSR74.3
Corresponding_CDS_historyR74.3:wp166
R74.3a:wp275
R74.3c:wp275
Corresponding_transcriptR74.3.1
R74.3.2
Other_sequence (21)
Associated_feature (16)
Gene_product_bindsWBsf019101
Transcription_factorWBTranscriptionFactor000096
Experimental_infoRNAi_result (50)
Expr_patternExpr3424
Expr4095
Expr7648
Expr1017530
Expr1032970
Expr1155684
Expr2018089
Expr2036227
Drives_constructWBCnstr00011392
WBCnstr00012793
WBCnstr00034070
Construct_product (11)
Regulate_expr_clusterWBPaper00005432:xbp-1(zc12)_downregulated
WBPaper00005432:xbp-1(zc12)_upregulated
WBPaper00059175:hlh-17p-XBP-1_downregulated
WBPaper00059175:hlh-17p-XBP-1_upregulated
AntibodyWBAntibody00001600
Microarray_results (30)
Expression_cluster (170)
Interaction (117)
WBProcessWBbiopr:00000039
WBbiopr:00000046
WBbiopr:00000050
WBbiopr:00000079
Map_infoMapIIIPosition-3.69579Error0.005385
PositivePositive_cloneR74Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point5012
4785
Pseudo_map_position
Reference (132)
RemarkSequence connection from [Ron D]. krb 14/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene