pxn-2 encodes a member of the peroxidasin family of extracellular peroxidases containing several LLRs, two of four Ig domains and a heme peroxidase catalytic domain, PXN-2 is closely related to human PXDN and PXDNL (OMIM: 605158); PXN-2 function becomes critical soon after the twofold stage of epidermal elongation in embryos; pxn-2 mutants display defects in late stages of epidermal elongation, in muscle and epidermal muscle attachments, in vulval muscle attachment and in morphology of adult pharynx; PXN-2 supports a role in basement membrane function and in neuronal development, PXN-2 acts in selective axon guidance decisions but not essential for axon growth; PXN-2 inhibits adult axon regrowth after injury; PXN-1 acts antagonistically to PXN-2; PXN-2 expressed in differentiated epidermal cell throughout embryonic, larval and adult development, in vulval muscles and a few neurons, in longitudinal striations adjacent to the body wall muscle quadrant close to endogenous basement membrane components.
Predicted to enable peroxidase activity. Involved in several processes, including embryonic body morphogenesis; muscle attachment; and regulation of cellular component organization. Located in basement membrane. Expressed in PVQL; PVQR; hypodermis; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; asthma (multiple); kidney failure (multiple); and lung disease (multiple). Is an ortholog of human PXDN (peroxidasin) and PXDNL (peroxidasin like).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.