WormBase Tree Display for Gene: WBGene00004003

WBGene00004003 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 1
    Name: CGC_name: pgp-9 Person_evidence: WBPerson490
      Sequence_name: C47A10.1
      Molecular_name: C47A10.1
        C47A10.1.1
        CE15714
      Other_name: CELE_C47A10.1 Accession_evidence: NDB BX284605
      Public_name: pgp-9
    DB_info: Database: AceView gene 5S243
        WormQTL gene WBGene00004003
        WormFlux gene WBGene00004003
        NDB locus_tag CELE_C47A10.1
        Panther gene CAEEL|WormBase=WBGene00004003|UniProtKB=G5EG58
          family PTHR24221
        NCBI gene 180165
        RefSeq protein NM_075086.6
        TrEMBL UniProtAcc G5EG58
        UniProt_GCRP UniProtAcc G5EG58
        OMIM gene 171050
            171060
            603201
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pgp
    Allele (249)
    Strain: WBStrain00003585
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00023572 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023573 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023575 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023577 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00026762 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00028069 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00033821 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00034135 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00034271 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037005 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037006 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037161 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037162 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037165 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00162590 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00073323 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00218942 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00218740 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      CBOVI.g1651 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g1653 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g9042 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3568 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g5940 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g8621 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g3825 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6015 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g1575 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g6315 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g23404 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_07056.g20657 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-pgp-9 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g21863 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00355.g9985 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_14231 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_021823 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06835 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07803 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g603 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50405910 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g17544 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00207649 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00216516 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00075632 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00256217 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000001692 Saccharomyces cerevisiae From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      FB:FBgn0004512 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0010241 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      FB:FBgn0035695 Drosophila melanogaster From_analysis: Hieranoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0004513 Drosophila melanogaster From_analysis: Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-050517-14 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050517-13 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6414 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-080204-52 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:40 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:45 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:42 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:46 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:97568 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:97569 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:97570 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1351619 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1924956 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:3318 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
      RGD:620248 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
      RGD:1566342 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
    Paralog (23)
    Structured_description: Concise_description: pgp-9 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-9 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, and loss of pgp-9 activity via RNAi can result in embryonic lethality; pgp-9 promoter-gfp fusion proteins are expressed in the pharynx (first and second bulbs) and in the intestine. Paper_evidence: WBPaper00004651
            WBPaper00006421
            WBPaper00006525
            WBPaper00024561
          Curator_confirmed: WBPerson1843
          Date_last_updated: 07 Mar 2006 00:00:00
      Automated_description: Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (41)
  Molecular_info (4)
  Experimental_info: RNAi_result: WBRNAi00077359 Inferred_automatically: RNAi_primary
      WBRNAi00070085 Inferred_automatically: RNAi_primary
      WBRNAi00042636 Inferred_automatically: RNAi_primary
      WBRNAi00012052 Inferred_automatically: RNAi_primary
      WBRNAi00001328 Inferred_automatically: RNAi_primary
      WBRNAi00022567 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1652
      Expr3340
      Expr5518
      Expr5519
      Expr1024605
      Expr1031915
      Expr1146620
      Expr2014876
      Expr2033111
    Drives_construct: WBCnstr00002006
      WBCnstr00002007
      WBCnstr00004037
      WBCnstr00011336
    Microarray_results (19)
    Expression_cluster (251)
    Interaction (24)
  Map_info: Map: V Position: 13.1928 Error: 0.00649
    Positive: Positive_clone: C47A10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5600
        4301
    Pseudo_map_position
  Reference (10)
  Remark: Sequence connection from [Sheps JA, Baillie DL] [040902 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene