WormBase Tree Display for Gene: WBGene00002008

WBGene00002008 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: hsp-4 Person_evidence: WBPerson36
      Sequence_name: F43E2.8
      Molecular_name: F43E2.8a
        F43E2.8a.1
        CE07244
        F43E2.8b
        CE49318
        F43E2.8a.2
        F43E2.8b.1
      Other_name: hsp70er2 Paper_evidence: WBPaper00064398
        CELE_F43E2.8 Accession_evidence: NDB BX284602
      Public_name: hsp-4
    DB_info: Database: AceView gene 2H640
        WormQTL gene WBGene00002008
        WormFlux gene WBGene00002008
        NDB locus_tag CELE_F43E2.8
        Panther gene CAEEL|WormBase=WBGene00002008|UniProtKB=P20163
          family PTHR19375
        NCBI gene 174203
        RefSeq protein NM_001383885.2
            NM_001306541.3
        SwissProt UniProtAcc P20163
        TrEMBL UniProtAcc V6CL98
        UniProt_GCRP UniProtAcc P20163
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsp
    Allele (28)
    Legacy_information: [C.elegansII] NMK. Encodes protein related to mammalian grp78/BiP; strongly induced by heat shock. [Heschl and Baillie 1990; BC]
    Strain: WBStrain00036323
      WBStrain00051694
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog: WBGene00054328 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00023842 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00033953 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00034025 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00035220 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037693 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00038688 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00038690 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00040668 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00153359 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00129022 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00066157 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00193354 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00233922 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6427 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g2344 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g6962 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g12196 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g9263 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g20352 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7003 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP39.g15986 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g19496 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g5822 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g6753 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g8339 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00115.g4782 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_28700.g27673 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_II.g5331 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g24080 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold526.g3080 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00343.g9786 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_09443 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_09450 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_006486 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_006489 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03354 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g13178 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_20257100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g4999 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00054355 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00084752 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00239175 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00291796 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003571 Saccharomyces cerevisiae From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0001218 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-031001-11 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:5238 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:95835 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2843 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (11)
    Structured_description: Concise_description: hsp-4 encodes one of two C. elegans heat shock response 70 (hsp70) proteins homologous to mammalian grp78/BiP (glucose regulated protein 78/immunoglobulin heavy chain-binding protein, OMIM:138120); hsp-4 affects embryonic and larval viability; hsp-4 is expressed in several tissues including the hypodermis, intestine, and spermatheca; hsp-4 transcription is upregulated in response to endoplasmic reticulum stress induced by dithiothreitol (DTT) or tunicamycin (unfolded protein response) as well as in response to heat shock and treatment of animals with pore-forming toxins such as Cry5B. Paper_evidence: WBPaper00001136
            WBPaper00001320
            WBPaper00005036
            WBPaper00005044
            WBPaper00006395
            WBPaper00024269
            WBPaper00031857
            WBPaper00032255
            WBPaper00005432
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 25 Oct 2013 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in endoplasmic reticulum unfolded protein response. Located in rough endoplasmic reticulum. Expressed in PVDL; PVDR; intestinal muscle; and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including dopamine beta-hydroxylase deficiency; inflammatory bowel disease; and rheumatoid arthritis. Is an ortholog of human HSPA5 (heat shock protein family A (Hsp70) member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
      DOID:3070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
      DOID:0090145 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
      DOID:0050589 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5238)
  Molecular_info: Corresponding_CDS: F43E2.8a
      F43E2.8b
    Corresponding_transcript: F43E2.8a.1
      F43E2.8a.2
      F43E2.8b.1
    Other_sequence (44)
    Associated_feature: WBsf650221
      WBsf650222
      WBsf650223
      WBsf665682
      WBsf665683
      WBsf988418
      WBsf1012519
  Experimental_info: RNAi_result (26)
    Expr_pattern (17)
    Drives_construct: WBCnstr00002743
      WBCnstr00005157
      WBCnstr00009660
      WBCnstr00013152
      WBCnstr00014616
      WBCnstr00016655
      WBCnstr00018297
      WBCnstr00020788
      WBCnstr00036525
    Construct_product (2)
    Microarray_results (19)
    Expression_cluster (233)
    Interaction (399)
    WBProcess: WBbiopr:00000046
      WBbiopr:00000076
      WBbiopr:00000079
      WBbiopr:00000121
  Map_info: Map: II Position: 0.502202 Error: 0.000194
    Positive: Positive_clone: F43E2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5625
        4390
    Pseudo_map_position
  Reference (124)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene