WormBase Tree Display for Gene: WBGene00001502

WBGene00001502 SMap: S_parent: Sequence: F52D10
  Identity: Version: 1
    Name: CGC_name: ftt-2 Person_evidence: WBPerson577
      Sequence_name: F52D10.3
      Molecular_name: F52D10.3a
        F52D10.3a.1
        CE03389
        F52D10.3c
        CE51934
        F52D10.3c.1
      Other_name: CELE_F52D10.3 Accession_evidence: NDB BX284606
      Public_name: ftt-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ftt
    Allele (31)
    Legacy_information: [Iino Y] predicted gene product has sequence similarity to the 14-3-3 family of proteins.
    Strain: WBStrain00027454
      WBStrain00055539
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog: WBGene00058258 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00036963 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00143894 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00123173 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00224520 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229844 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g11962 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g8448 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1860 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g18799 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g15791 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g10028 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5757 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g5468 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g28757 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12595 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00054.g2817 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_X.g23141 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold44.g251 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_03096.g29041 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01095 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_023812 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04091 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2511 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0091400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20095 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239934 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304616 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00286406 Trichuris muris From_analysis: WormBase-Compara
      WBGene00301276 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000002506 Saccharomyces cerevisiae From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      SGD:S000000979 Saccharomyces cerevisiae From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      FB:FBgn0004907 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-448 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6583 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-7135 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-8554 Danio rerio From_analysis: OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-040122-5 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2160 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10773 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:12849 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:12855 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:12854 Homo sapiens From_analysis: Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:891963 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:109484 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1891917 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1891831 Mus musculus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:3979 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:3980 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:61998 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1359510 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:1304729 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
    Paralog: WBGene00003920 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00010919 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ftt-2 encodes a 14-3-3 protein; FTT-2 is required for regulating the localization of the product of YAP-1, a Yes-associated protein (Yap) homolog, between the cytoplasm and the nucleus. Paper_evidence: WBPaper00041976
            WBPaper00002793
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Mar 2013 00:00:00
      Automated_description: Enables DNA-binding transcription factor binding activity. Involved in cytoplasmic sequestering of protein; dauer larval development; and negative regulation of protein import into nucleus. Located in cytoplasm and nucleus. Expressed in several structures, including C; E; Psub3; gonad; and intestine. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8719 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12855)
      DOID:2101 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
  Molecular_info: Corresponding_CDS (2)
    Corresponding_CDS_history: F52D10.3b:wp121
      F52D10.3b:wp271
    Corresponding_transcript: F52D10.3a.1
      F52D10.3c.1
    Other_sequence (379)
    Associated_feature (22)
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr677
      Expr678
      Expr3992
      Expr4515
      Expr14505
      Expr1014656
      Expr1030902
      Expr1151782
      Expr2011916
      Expr2030153
    Drives_construct: WBCnstr00009103
      WBCnstr00012073
      WBCnstr00036906
    Construct_product: WBCnstr00009103
      WBCnstr00012073
      WBCnstr00036906
    Antibody: WBAntibody00001182
    Microarray_results (31)
    Expression_cluster (201)
    Interaction (399)
    WBProcess: WBbiopr:00000025
  Map_info: Map: X Position: 4.88794 Error: 0.044755
    Positive: Positive_clone: F52D10 Person_evidence: WBPerson284
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5040
    Pseudo_map_position
  Reference (37)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene