chs-1 encodes a chitin synthase, paralogous to CHS-2; chs-1 is requiredfor embryonic chitin synthesis, eggshell synthesis and osmoticintegrity, error-free chromosomal segregation during meiosis, polar bodyextrusion, association of the sperm pronucleus/centrosome complex (SPCC)with the early embryonic cortex, localization of PAR-2 in early embryos,posterior localization of P granules or PIE-1, and pseudocleavage; CHS-1is also, independently of chitin synthesis, required for normallocalization of MBK-2 to cortex and punctae in early embryos; CHS-1 isdispensable for synthesis of pharyngeal cuticle, since chs-1(ok1120)mutants have it normally; CHS-1 localizes to the oocyte plasma membrane and .cell cortex
Predicted to enable chitin synthase activity. Involved in cell wall chitin biosynthetic process; eggshell formation; and positive regulation of protein localization to cell cortex. Located in cell cortex and plasma membrane. Expressed in Psub1.
Gene was renamed from chi-1 to chs-1 at request of CGC, note that the other name 'chs-2' is from the Brugia malayi ortholog...this ortholog may be renamed in the future to clarify the situation.
CGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.