cah-4 encodes a carbonic anhydrase homolog, which is rather divergent from other such homologs in C. elegans (with at most 38% identity to any other carbonic anhydrase, in or out of C. elegans); it is individually dispensable for viability and for grossly normal postembryonic morphology, and thus may have a more subtle biological function than the basic cytoprotective functions expected for carbonic anhydrases.
Enables carbonate dehydratase activity. Involved in small molecule metabolic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; enteric muscle; excretory cell; rectal muscle; and somatic nervous system. Is an ortholog of several human genes including CA1 (carbonic anhydrase 1); CA3 (carbonic anhydrase 3); and CA5A (carbonic anhydrase 5A).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.