WormBase Tree Display for Gene: WBGene00000233

WBGene00000233 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 1
    Name: CGC_name: avr-15 Person_evidence: WBPerson1122
      Sequence_name: R11G10.1
      Molecular_name: R11G10.1a
        R11G10.1a.1
        CE25076
        R11G10.1b
        CE13573
        R11G10.1c
        CE45109
        R11G10.1b.1
        R11G10.1c.1
      Other_name: CELE_R11G10.1 Accession_evidence: NDB BX284605
      Public_name: avr-15
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: avr
    Allele (310)
    Legacy_information: [Dent JA] >20x synthetic avermectin resistance. Lacks M3 neurotransmission. Slightly starved. Prolonged pharyngeal contractions. Encodes ivermectin-sensitive glutamate-gated chloride channel subunit (?predicted gene T10G3.6).
      ad1051 : Eat phenotype, lacks M3-derived IPSP; isolated pharynx insensitive to iontophoretically applied glutamate.[CD; AD]
    Strain (15)
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog: WBGene00028929 Caenorhabditis briggsae From_analysis: OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00157438 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00157177 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00139250 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00151278 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00119924 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00055316 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00055768 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00081417 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00129121 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00139571 Caenorhabditis brenneri From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00121244 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00052811 Caenorhabditis remanei From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00116165 Pristionchus pacificus From_analysis: Inparanoid_8
      CBOVI.g753 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11032 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g19819 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3073 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g19092 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12093 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8262 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g1970 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9166 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g7742 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00337.g9409 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_05232.g19452 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_08265.g21404 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g18532 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold282.g736 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00998.g17423 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03810 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_018588 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g00171 Oscheius tipulae From_analysis: WormBase-Compara
      chrV_pilon.g16260 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00209169 Caenorhabditis japonica From_analysis: WormBase-Compara
      FB:FBgn0024963 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-991117-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010410-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010410-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020402-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020402-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040801-106 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-090407-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:4327 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:4329 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:4328 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:95747 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95750 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95751 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95749 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95748 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2705 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2706 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2704 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621229 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1564103 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (100)
    Structured_description: Concise_description: avr-15 encodes, via alternative splicing, two glutamate-gated chloride channel subunit homologs; these proteins mediate fast inhibitory glutamatergic neuromuscular transmission, as well as ivermectin sensitivity, and are required for normal pharyngeal function. Paper_evidence: WBPaper00002920
            WBPaper00003954
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in action potential; locomotion involved in locomotory behavior; and regulation of pharyngeal pumping. Predicted to be located in neuron projection and synapse. Expressed in motor neurons; pharynx; preanal ganglion neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in hyperekplexia 2 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2); GLRA3 (glycine receptor alpha 3); and GLRB (glycine receptor beta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070422 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4327)
      DOID:0060697 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4329)
  Molecular_info: Corresponding_CDS: R11G10.1a
      R11G10.1b
      R11G10.1c
    Corresponding_CDS_history: R11G10.1:wp51
    Corresponding_transcript: R11G10.1a.1
      R11G10.1b.1
      R11G10.1c.1
    Other_sequence (39)
    Associated_feature: WBsf653315
      WBsf653316
      WBsf653317
      WBsf653318
      WBsf1001831
      WBsf1001832
      WBsf1020728
      WBsf234818
      WBsf234819
      WBsf234820
  Experimental_info: RNAi_result: WBRNAi00018559 Inferred_automatically: RNAi_primary
      WBRNAi00030215 Inferred_automatically: RNAi_primary
      WBRNAi00085183 Inferred_automatically: RNAi_primary
      WBRNAi00017762 Inferred_automatically: RNAi_primary
      WBRNAi00051804 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1454
      Expr1799
      Expr13471
      Expr13480
      Expr1011432
      Expr1155465
      Expr2009524
      Expr2027761
    Drives_construct: WBCnstr00004936
      WBCnstr00010282
      WBCnstr00010455
      WBCnstr00015856
    Construct_product (13)
    Microarray_results (31)
    Expression_cluster (163)
    Interaction (14)
  Map_info: Map: V Position: 5.39241 Error: 0.010538
    Well_ordered
    Positive: Positive_clone: K10B8
        R11G10 Inferred_automatically: From sequence, transcript, pseudogene data
        T10G3
    Negative: Outside_rearr: yDf8
    Mapping_data (2)
  Reference (65)
  Remark: T10G3.7 sequence removed, now named R11G10.1 in sequence annotation. [sdm 05/00]
  Method: Gene