WormBase Tree Display for Gene: WBGene00006722

WBGene00006722 Evidence: Person_evidence: WBPerson2549
      WBPerson6733
  SMap: S_parent: Sequence: F46E10
  Identity: Version: 1
    Name: CGC_name: ubh-2
      Sequence_name: Y40G12A.2
      Molecular_name: Y40G12A.2
        Y40G12A.2.1
        CE52436
      Other_name: CELE_Y40G12A.2 Accession_evidence: NDB BX284605
      Public_name: ubh-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ubh
    Allele (14)
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP5120
    Ortholog: WBGene00119596 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00145316 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00052168 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00234107 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g1771 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g5608 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP28.g8739 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g5506 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g5507 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11262 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g14906 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g10694 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8792 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      Cang_2012_03_13_00182.g6387 Caenorhabditis angaria From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04477 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_50214300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g14450 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242777 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258134 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000003860 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0010288 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-3844 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050522-158 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:12513 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:12515 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:103149 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1355274 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1890440 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:3928 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1561196 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00006721 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006723 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00006724 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Enables deNEDDylase activity and deubiquitinase activity. Involved in protein deneddylation. Predicted to be located in cytoplasm. Expressed in intestinal cell and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12513)
      DOID:0070455 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12513)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12513)
      DOID:0112344 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12513)
  Molecular_info: Corresponding_CDS: Y40G12A.2
    Corresponding_CDS_history: Y40G12A.2:wp262
    Corresponding_transcript: Y40G12A.2.1
    Other_sequence: LSC00943_1
      HBC17894_1
      DN557968.1
      Acan_isotig18948
      Tcol_isotig03120
      CR11429
      CA953616.1
      TSC06329_1
      RSC00878_1
      CA840881.1
      Oden_isotig04761
      JI472287.1
      ES741340.1
      MCC01731_1
      Oden_isotig04762
      Oden_isotig04759
      Tcol_isotig03119
      CA840834.1
      MC00729
      CA840728.1
      RS10127
      Tcol_isotig03118
      Oden_isotig04760
    Associated_feature: WBsf233814
  Experimental_info: RNAi_result: WBRNAi00015094 Inferred_automatically: RNAi_primary
      WBRNAi00098015 Inferred_automatically: RNAi_primary
      WBRNAi00076786 Inferred_automatically: RNAi_primary
      WBRNAi00098010 Inferred_automatically: RNAi_primary
      WBRNAi00056335 Inferred_automatically: RNAi_primary
      WBRNAi00056334 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15526
      Expr1019739
      Expr1159823
      Expr2017719
      Expr2035857
    Drives_construct: WBCnstr00042222
    Construct_product: WBCnstr00042222
    Microarray_results (15)
    Expression_cluster (78)
    Interaction (18)
  Map_info: Map: V Position: -0.04818 Error: 0.006448
    Positive: Positive_clone: Y40G12A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00010020
    WBPaper00025802
    WBPaper00030133
    WBPaper00038491
    WBPaper00055090
    WBPaper00060977
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene