WormBase Tree Display for Gene: WBGene00003479
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| WBGene00003479 | Evidence | Paper_evidence | WBPaper00006051 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Person_evidence | WBPerson170 | ||||||||
| SMap | S_parent | Sequence | Y39H10A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mtm-9 | Person_evidence | WBPerson170 | |||||
| Sequence_name | Y39H10A.3 | ||||||||
| Molecular_name | Y39H10A.3a | ||||||||
| Y39H10A.3a.1 | |||||||||
| CE26073 | |||||||||
| Y39H10A.3b | |||||||||
| CE36959 | |||||||||
| Y39H10A.3b.1 | |||||||||
| Other_name (4) | |||||||||
| Public_name | mtm-9 | ||||||||
| DB_info | Database | AceView | gene | 5E227 | |||||
| WormQTL | gene | WBGene00003479 | |||||||
| WormFlux | gene | WBGene00003479 | |||||||
| NDB | locus_tag | CELE_Y39H10A.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003479|UniProtKB=Q965W9 | |||||||
| family | PTHR10807 | ||||||||
| NCBI | gene | 178790 | |||||||
| RefSeq | protein | NM_182367.6 | |||||||
| NM_071637.7 | |||||||||
| SwissProt | UniProtAcc | Q965W9 | |||||||
| UniProt_GCRP | UniProtAcc | Q965W9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mtm | ||||||||
| Allele (128) | |||||||||
| Strain | WBStrain00033216 | ||||||||
| WBStrain00008043 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00003475 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003476 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003477 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021683 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003478 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mtm-9 encodes a catalytically inactive myotubularin lipid phosphatase orthologous to human MTMR9 (OMIM:606260) that affects phosphoinositide 3-phosphate localization, and whose mutation blocks endocytosis by the coelomocytes of C. elegans; MTM-9 is believed to function as part of a complex with MTM-6A and it is predominantly localized to the coelomocyte cytoplasm, with some localization to the membrane. | Paper_evidence | WBPaper00004883 | |||||
| WBPaper00006306 | |||||||||
| WBPaper00037794 | |||||||||
| WBPaper00044932 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 02 Apr 2014 00:00:00 | ||||||||
| Automated_description | Enables phosphatase binding activity. Involved in pinocytosis and regulation of cell migration. Located in cytosol and plasma membrane. Expressed in several structures, including CAN; PDE; coelomocyte; epithelial cell; and vulva. Used to study centronuclear myopathy. Is an ortholog of human MTMR9 (myotubularin related protein 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14717 | Homo sapiens | Paper_evidence | WBPaper00006306 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Oct 2018 00:00:00 | ||||||||
| Disease_relevance | Mutations in the human myotubularin family of lipid phosphatases, are associated with myotubular myopathy (associated gene, MTM1) and Charcot-Marie-Tooth disease, a group of progressive demyelinating neuropathies that affect the peripheral nerves (associated gene, MTMR2); studies in C. elegans indicate that, elegans mtm-9 together with mtm-6, and possibly other myotubularins, act in the arf-6/ARF6, rme-1/Ehd pathway for endocytosis, suggesting that disruptions in this endocytic pathway may be one of the causes leading to disease. | Homo sapiens | Curator_confirmed | WBPerson324 | |||||
| Date_last_updated | 05 Mar 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000278 | ||||||||
| Molecular_info | Corresponding_CDS | Y39H10A.3a | |||||||
| Y39H10A.3b | |||||||||
| Corresponding_CDS_history | Y39H10A.3:wp126 | ||||||||
| Y39H10A.3b:wp102 | |||||||||
| Corresponding_transcript | Y39H10A.3a.1 | ||||||||
| Y39H10A.3b.1 | |||||||||
| Other_sequence (70) | |||||||||
| Associated_feature | WBsf718290 | ||||||||
| WBsf231602 | |||||||||
| WBsf231603 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00097617 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00065085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056293 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091925 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020434 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065086 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091926 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097613 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097619 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2826 | ||||||||
| Expr9224 | |||||||||
| Expr1016199 | |||||||||
| Expr1031595 | |||||||||
| Expr1159780 | |||||||||
| Expr2013813 | |||||||||
| Expr2032053 | |||||||||
| Drives_construct | WBCnstr00010974 | ||||||||
| WBCnstr00013810 | |||||||||
| WBCnstr00036089 | |||||||||
| Construct_product | WBCnstr00010974 | ||||||||
| WBCnstr00036089 | |||||||||
| Microarray_results | SMD_Y39H10A_225.E | ||||||||
| 173289_s_at | |||||||||
| 174868_s_at | |||||||||
| 176520_at | |||||||||
| A_12_P117919 | |||||||||
| A_12_P134360 | |||||||||
| A_12_P175192 | |||||||||
| Aff_Y39H10A_225.E | |||||||||
| GPL13394_WBGene00003479 | |||||||||
| GPL13914_Y39H10A.3 | |||||||||
| GPL14144_Y39H10A.3a_597-656_0.847_36_C | |||||||||
| GPL14144_Y39H10A.3a_851-910_0.836_43_B | |||||||||
| GPL14144_Y39H10A.3a_972-1031_0.899_10_A | |||||||||
| GPL19516_CGZ0013116 | |||||||||
| GPL19516_CGZ0045034 | |||||||||
| GPL19516_CGZ0045035 | |||||||||
| GPL21109_Cat_Y39H10A.3a | |||||||||
| GPL21109_Y39H10A.3a | |||||||||
| GPL3518_CE26073 | |||||||||
| GPL8304_CE_WBGene00003479_A | |||||||||
| GPL8304_CE_WBGene00003479_B | |||||||||
| GPL8304_CE_WBGene00003479_C | |||||||||
| GPL8673_Y39H10A_3aP00282 | |||||||||
| GPL8673_Y39H10A_3aP00746 | |||||||||
| GPL8673_Y39H10A_3aP01123 | |||||||||
| GPL8673_Y39H10A_3bP00227 | |||||||||
| GPL8673_Y39H10A_3bP00602 | |||||||||
| GPL8673_Y39H10A_3bP00979 | |||||||||
| GPL9450_Y39H10A.3 | |||||||||
| cea2.p.128272 | |||||||||
| Expression_cluster (132) | |||||||||
| Interaction | WBInteraction000031311 | ||||||||
| WBInteraction000113006 | |||||||||
| WBInteraction000354169 | |||||||||
| WBInteraction000374757 | |||||||||
| WBInteraction000388237 | |||||||||
| WBInteraction000501484 | |||||||||
| WBInteraction000562612 | |||||||||
| WBInteraction000562613 | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | V | Position | -8.01374 | Error | 0.016451 | |||
| Positive | Positive_clone | Y39H10A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 3957 | |||||||
| 4277 | |||||||||
| Pos_neg_data | 10779 | ||||||||
| Reference (12) | |||||||||
| Method | Gene |
