WormBase Tree Display for Gene: WBGene00001032
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| WBGene00001032 | SMap | S_parent | Sequence | K02G10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dnj-14 | Person_evidence | WBPerson625 | |||||
| Sequence_name | K02G10.8 | ||||||||
| Molecular_name | K02G10.8a | ||||||||
| K02G10.8a.1 | |||||||||
| CE04708 | |||||||||
| K02G10.8b | |||||||||
| CE45638 | |||||||||
| K02G10.8b.1 | |||||||||
| Other_name | CELE_K02G10.8 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | dnj-14 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (10) | |||||||||
| Disease_info | Experimental_model | DOID:14503 | Homo sapiens | Paper_evidence | WBPaper00045410 | ||||
| Accession_evidence | OMIM | 162350 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
| Potential_model | DOID:0110720 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16235) | |||||
| Disease_relevance | Mutations in human DNAJC5 are implicated in adult onset neuronal lipofuscinosis (ANCL; Kufs disease and Parry disease), a neurodegenerative disorder characterised by progressive neuronal dysfunction and premature death; DNAJC5 encodes an evolutionarily conserved member of the DnaJ/Hsp40 family of molecular chaperones known as cysteine string protein (CSP); in C. elegans, mutants of dnj-14 (tm3223, ok237), which is orthologous to human DNAJC5, show reduced life-span, impaired locomotion, reduced neurotransmission and impaired chemosensation; older dnj-14 animals exhibited neuronal abnormalities like loss of neuronal cell bodies, reduction in the number of visible neurites, and the presence of contorted neuronal processes; use of this dnj-14 model identified resveratrol as a compound that could extend dnj-14 mutant lifespan, partially rescue the neurodegeneration phenotype and significantly ameliorate the chemotaxis defects of dnj-14 mutants; this resveratrol activity was mimicked by phosphodiesterase inhibition and independent of SIR-2.1/Sirtuin, unlike in other C. elegans neurodegeneration models where resveratrol activity was shown to be sir-2.1 dependent. | Homo sapiens | Paper_evidence | WBPaper00045410 | |||||
| Accession_evidence | OMIM | 611203 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000331 | ||||||||
| WBDOannot00000409 | |||||||||
| WBDOannot00000410 | |||||||||
| Molecular_info | Corresponding_CDS | K02G10.8a | |||||||
| K02G10.8b | |||||||||
| Corresponding_transcript | K02G10.8a.1 | ||||||||
| K02G10.8b.1 | |||||||||
| Other_sequence (30) | |||||||||
| Associated_feature | WBsf653929 | ||||||||
| WBsf670453 | |||||||||
| WBsf982161 | |||||||||
| WBsf237308 | |||||||||
| WBsf237309 | |||||||||
| WBsf237310 | |||||||||
| WBsf237311 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016500 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00106560 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106561 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106329 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033900 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076542 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049772 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1021089 | ||||||||
| Expr1030644 | |||||||||
| Expr1153487 | |||||||||
| Expr2010988 | |||||||||
| Expr2029226 | |||||||||
| Drives_construct | WBCnstr00042947 | ||||||||
| Regulate_expr_cluster | WBPaper00048567:dnj-14_downregulated | ||||||||
| WBPaper00048567:dnj-14_upregulated | |||||||||
| Microarray_results | SMD_K02G10.8 | ||||||||
| 175242_at | |||||||||
| 185615_at | |||||||||
| A_12_P116411 | |||||||||
| A_12_P159745 | |||||||||
| A_12_P159746 | |||||||||
| A_12_P159747 | |||||||||
| A_12_P159748 | |||||||||
| A_12_P159749 | |||||||||
| Aff_K02G10.8 | |||||||||
| GPL13394_WBGene00001032 | |||||||||
| GPL13914_K02G10.8 | |||||||||
| GPL14144_K02G10.8_178-237_0.916_8_B | |||||||||
| GPL14144_K02G10.8_263-322_0.939_3_A | |||||||||
| GPL14144_K02G10.8_81-140_0.904_11_C | |||||||||
| GPL19516_CGZ0011674 | |||||||||
| GPL19516_CGZ0027502 | |||||||||
| GPL19516_CGZ0027503 | |||||||||
| GPL21109_K02G10.8a | |||||||||
| GPL21109_K02G10.8b | |||||||||
| GPL3518_CE04708 | |||||||||
| GPL8304_CE_WBGene00001032_A | |||||||||
| GPL8304_CE_WBGene00001032_C | |||||||||
| GPL8673_K02G10_8P00066 | |||||||||
| GPL8673_K02G10_8P00274 | |||||||||
| GPL8673_K02G10_8P00574 | |||||||||
| GPL9450_K02G10.8 | |||||||||
| cea2.p.149047 | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (44) | |||||||||
| Map_info | Map | X | Position | -6.83097 | Error | 0.016329 | |||
| Positive | Positive_clone | K02G10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4264 | |||||||
| 5084 | |||||||||
| 5264 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
