WormBase Tree Display for Gene: WBGene00000497

WBGene00000497 SMap: S_parent: Sequence: F48A11
  Identity: Version: 3
    Name: CGC_name: chs-2 Person_evidence: WBPerson50
      Sequence_name: F48A11.1
      Molecular_name: F48A11.1a
        F48A11.1a.1
        CE39155
        F48A11.1b
        CE50690
        F48A11.1c
        CE50769
        F48A11.1b.1
        F48A11.1c.1
      Other_name: chs-1
        chi-2 CGC_data_submission
        CELE_F48A11.1 Accession_evidence: NDB BX284602
      Public_name: chs-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change (3)
      Acquires_merge: WBGene00018583
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: chs
    Allele (220)
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (47)
    Paralog: WBGene00000496 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: chs-2 encodes a putative chitin synthase, paralogous to CHS-1; CHS-2 isrequired for synthesis of chitin lining the inner pharyngeal surface(primarily in the buccal cavity and grinder), while CHS-1 is dispensablefor pharyngeal chitin; CHS-2 is also required for normal pharyngealshape and function, and for larval viability; chs-2(RNAi) animals haveabnormally large, misshapen grinders, and arrest as early larvae; chs-2is expressed by the glandular pharyngeal g1 and g2 cells, and by m3 andm4 myoepithelial cells; chs-2 is transcribed in short periods beforeeach larval molt; the pharyngeal expression of chs-2 parallels gna-1;CHS-2 is predicted to be in the plasma membrane rather than the Golgiapparatus. Paper_evidence: WBPaper00004881
            WBPaper00006390
            WBPaper00012846
            WBPaper00026721
            WBPaper00028588
            WBPaper00029233
          Curator_confirmed: WBPerson567
          Date_last_updated: 07 Apr 2007 00:00:00
      Automated_description: Predicted to enable chitin synthase activity. Involved in chitin biosynthetic process and positive regulation of nematode larval development. Predicted to be located in cell periphery and cell septum. Expressed in pharynx. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F48A11.1a
      F48A11.1b
      F48A11.1c
    Corresponding_CDS_history: F48A11.1:wp149
    Corresponding_transcript: F48A11.1a.1
      F48A11.1b.1
      F48A11.1c.1
    Other_sequence (17)
    Associated_feature (17)
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr3654
      Expr11043
      Expr1021151
      Expr1024170
      Expr1030293
      Expr1151543
      Expr1151544
      Expr2010000
      Expr2028241
    Drives_construct: WBCnstr00009128
      WBCnstr00011575
      WBCnstr00017872
      WBCnstr00023060
    Microarray_results: SMD_F48A11.1
      SMD_F48A11.1:2
      SMD_F48A11.2
      SMD_F48A11.3
      184880_at
      185172_s_at
      185232_at
      A_12_P118273
      A_12_P119201
      A_12_P156435
      A_12_P156436
      A_12_P156437
      A_12_P156438
      A_12_P156439
      Aff_F48A11.1
      Aff_F48A11.2
      Aff_F48A11.3
      GPL13394_WBGene00000497
      GPL13394_WBGene00018583
      GPL13914_F48A11.1
      GPL13914_F48A11.2
      GPL14144_F48A11.1_2269-2328_0.795_135_C
      GPL14144_F48A11.1_2337-2396_0.805_116_A
      GPL14144_F48A11.1_2513-2572_0.804_119_B
      GPL14144_F48A11.2_1-60_0.905_4_A
      GPL14144_F48A11.2_109-168_0.898_5_C
      GPL14144_F48A11.2_294-353_0.935_1_B
      GPL19516_CGZ0011439
      GPL19516_CGZ0022503
      GPL19516_CGZ0022505
      GPL21109_Cat_F48A11.2
      GPL21109_F48A11.1
      GPL21109_F48A11.2
      GPL3518_CE10722
      GPL3518_CE10726
      GPL8304_CE_WBGene00000497_A
      GPL8304_CE_WBGene00000497_B
      GPL8304_CE_WBGene00018583_A
      GPL8673_F48A11_1P03545
      GPL8673_F48A11_1P04050
      GPL8673_F48A11_1P04815
      GPL8673_F48A11_2P00024
      GPL8673_F48A11_2P00030
      GPL8673_F48A11_2P00263
      GPL9450_F48A11.1
      GPL9450_F48A11.3
      cea2.i.12750
      cea2.p.40149
    Expression_cluster (181)
    Interaction: WBInteraction000241924
      WBInteraction000463268
  Map_info: Map: II Position: -15.8229 Error: 0.018071
    Positive: Positive_clone: F48A11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Gene was renamed from chi-2 to chs-2 at request of CGC, note that the other name 'chs-1' is from the Brugia malayi ortholog...this ortholog may be renamed in the future to clarify the situation. CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene