pitp-1 encodes a phosphatidylinositol transfer protein, with a C-terminal DDHD domain, that is orthologous to RETINAL DEGENERATION B (RDGB) in D. melanogaster, as well as other orthologs in mammals (NIR1-3); pitp-1 is expressed in the egg membrane, the germline, the spermatheca and three pairs of head neurons; PITP-1 is predicted to mediate PIP(2) signalling in either neuronal function or cytokinesis.
Predicted to enable phospholipid binding activity and phospholipid transporter activity. Predicted to be involved in intermembrane lipid transfer and phospholipid transport. Located in ciliary transition zone and synapse. Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in cone-rod dystrophy 5. Is an ortholog of human PITPNM1 (phosphatidylinositol transfer protein membrane associated 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.