gly-1 encodes a transmembrane glycosyltransferase similar to 2/I N-acetylglucosaminyltransferase; in vitro, GLY-1 demonstrates UDP-Glc:GalB1-3GalNac-R glucosyltransferase activity; gly-1 expression is detected in adult hypodermal seam cells and possibly some neurons adjacent to the anterior bulb of the pharynx; neither gly-1 loss-of-function mutations nor RNA mediated interference (RNAi) result in any obvious abnormalities, suggesting that gly-1 function is not essential for C. elegans development and/or behavior.
Predicted to enable glycosyltransferase activity. Predicted to be located in Golgi membrane. Expressed in pharyngeal neurons and seam cell. Is an ortholog of several human genes including GCNT1 (glucosaminyl (N-acetyl) transferase 1); GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type); and GCNT4 (glucosaminyl (N-acetyl) transferase 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (3.13163)