wip-1 encodes the C. elegans ortholog of WASP-interacting protein; wip-1 is required for embryonic morphogenesis, specifically ventral enclosure; WIP-1 is predicted to bind G-actin and in a yeast two-hybrid assay WIP-1 physically interacts with WSP-1, the C. elegans WASP ortholog; WIP-1 and WSP-1 are mutually required for normal protein levels; WIP-1 is broadly expressed in the embryo and is found in migrating hypodermal cells during ventral enclosure.
Enables cytoskeletal regulatory protein binding activity. Involved in embryonic body morphogenesis; regulation of cell migration; and regulation of protein stability. Expressed in hypodermis. Is an ortholog of human WIPF1 (WAS/WASL interacting protein family member 1); WIPF2 (WAS/WASL interacting protein family member 2); and WIPF3 (WAS/WASL interacting protein family member 3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.