WormBase Tree Display for Gene: WBGene00006575

WBGene00006575 SMap: S_parent: Sequence: F13B10
  Identity: Version: 2
    Name: CGC_name: tir-1 Person_evidence: WBPerson168
      Sequence_name: F13B10.1
      Molecular_name (29)
      Other_name: nsy-2 Paper_evidence: WBPaper00024676
          Person_evidence: WBPerson42
        CELE_F13B10.1 Accession_evidence: NDB BX284603
      Public_name: tir-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tir
    Allele (424)
    Possibly_affected_by: WBVar02152927
    Strain: WBStrain00031789
      WBStrain00032827
      WBStrain00035844
      WBStrain00040806
      WBStrain00005265
      WBStrain00021983
      WBStrain00021984
    RNASeq_FPKM (74)
    GO_annotation (53)
    Ortholog (53)
    Structured_description: Concise_description: tir-1 encodes a Toll-Interleukin 1 Receptor (TIR) domain adaptor protein that is the C. elegans ortholog of human SARM (sterile alpha and armadillo repeats); tir-1 is required for innate immunity, as loss of tir-1 activity results in increased susceptibility to infection; tir-1 also functions in a lateral signaling pathway that specifies neuronal identity and is required for proper localization of NSY-1/MAPKKK to post-synaptic regions; TIR-1 physically interacts with a number of proteins, including UNC-43/CaMKII, the RAB-1 GTPase, and the ATP synthase f subunit encoded by R53.4; TIR-1 is expressed in neurons and localizes to post-synaptic regions of axons. Paper_evidence: WBPaper00004589
            WBPaper00006488
            WBPaper00006511
            WBPaper00024676
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 22 Mar 2013 00:00:00
      Automated_description: Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Expressed in head. Used to study amyotrophic lateral sclerosis. Is an ortholog of human SARM1 (sterile alpha and TIR motif containing 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:332 Homo sapiens Paper_evidence: WBPaper00046914
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Jul 2015 00:00:00
  Models_disease_in_annotation: WBDOannot00000352
  Molecular_info: Corresponding_CDS: F13B10.1a
      F13B10.1b
      F13B10.1c
      F13B10.1d
      F13B10.1e
      F13B10.1f
      F13B10.1g
      F13B10.1h
    Corresponding_CDS_history: F13B10.1c:wp248
    Corresponding_transcript (13)
    Other_sequence (45)
    Associated_feature (48)
  Experimental_info: RNAi_result (53)
    Expr_pattern: Expr3964
      Expr3965
      Expr5747
      Expr14886
      Expr1025922
      Expr1032710
      Expr1148422
      Expr2017410
      Expr2035549
    Drives_construct: WBCnstr00002582
      WBCnstr00006461
    Construct_product (18)
    Antibody: WBAntibody00001006
      WBAntibody00001007
    Microarray_results (57)
    Expression_cluster (277)
    Interaction: WBInteraction000002387
      WBInteraction000003890
      WBInteraction000003896
      WBInteraction000003897
      WBInteraction000005200
      WBInteraction000005373
      WBInteraction000007455
      WBInteraction000008261
      WBInteraction000029509
      WBInteraction000029518
      WBInteraction000030922
      WBInteraction000030941
      WBInteraction000031443
      WBInteraction000031588
      WBInteraction000031825
      WBInteraction000031846
      WBInteraction000031847
      WBInteraction000031848
      WBInteraction000031849
      WBInteraction000050842
      WBInteraction000052106
      WBInteraction000135588
      WBInteraction000135590
      WBInteraction000135615
      WBInteraction000137996
      WBInteraction000145295
      WBInteraction000304904
      WBInteraction000307295
      WBInteraction000336244
      WBInteraction000384349
      WBInteraction000384350
      WBInteraction000384351
      WBInteraction000410773
      WBInteraction000501319
      WBInteraction000503569
      WBInteraction000504059
      WBInteraction000504060
      WBInteraction000504063
      WBInteraction000504182
      WBInteraction000504797
      WBInteraction000504994
      WBInteraction000507184
      WBInteraction000507187
      WBInteraction000507188
      WBInteraction000507189
      WBInteraction000507190
      WBInteraction000513447
      WBInteraction000513449
      WBInteraction000513450
      WBInteraction000513451
      WBInteraction000513453
      WBInteraction000513454
      WBInteraction000513455
      WBInteraction000513456
      WBInteraction000513457
      WBInteraction000513458
      WBInteraction000513459
      WBInteraction000513460
      WBInteraction000513461
      WBInteraction000513462
      WBInteraction000513463
      WBInteraction000513464
      WBInteraction000513465
      WBInteraction000513466
      WBInteraction000513467
      WBInteraction000513468
      WBInteraction000513469
      WBInteraction000513470
      WBInteraction000513471
      WBInteraction000513472
      WBInteraction000513473
      WBInteraction000513474
      WBInteraction000513475
      WBInteraction000513476
      WBInteraction000513477
      WBInteraction000513478
      WBInteraction000513479
      WBInteraction000513480
      WBInteraction000513481
      WBInteraction000513482
      WBInteraction000513483
      WBInteraction000513484
      WBInteraction000513485
      WBInteraction000513486
      WBInteraction000513487
      WBInteraction000513488
      WBInteraction000513489
      WBInteraction000515219
      WBInteraction000516098
      WBInteraction000516333
      WBInteraction000516334
      WBInteraction000516335
      WBInteraction000516336
      WBInteraction000516337
      WBInteraction000516338
      WBInteraction000516339
      WBInteraction000516340
      WBInteraction000516341
      WBInteraction000516342
      WBInteraction000516343
      WBInteraction000516344
      WBInteraction000516345
      WBInteraction000516346
      WBInteraction000516347
      WBInteraction000516348
      WBInteraction000516349
      WBInteraction000516350
      WBInteraction000516351
      WBInteraction000516352
      WBInteraction000516353
      WBInteraction000516354
      WBInteraction000516355
      WBInteraction000516356
      WBInteraction000516357
      WBInteraction000516358
      WBInteraction000516359
      WBInteraction000516360
      WBInteraction000516361
      WBInteraction000516362
      WBInteraction000516363
      WBInteraction000516364
      WBInteraction000516365
      WBInteraction000516366
      WBInteraction000517588
      WBInteraction000517592
      WBInteraction000517743
      WBInteraction000517744
      WBInteraction000517745
      WBInteraction000518597
      WBInteraction000518619
      WBInteraction000518620
      WBInteraction000518737
      WBInteraction000519829
      WBInteraction000519831
      WBInteraction000524447
      WBInteraction000537516
      WBInteraction000542791
      WBInteraction000542836
      WBInteraction000542837
      WBInteraction000542838
      WBInteraction000542839
      WBInteraction000542840
      WBInteraction000542841
      WBInteraction000542842
      WBInteraction000542843
      WBInteraction000547638
      WBInteraction000547752
      WBInteraction000547753
      WBInteraction000547754
      WBInteraction000547755
      WBInteraction000547756
      WBInteraction000549830
      WBInteraction000549851
      WBInteraction000549870
      WBInteraction000549884
      WBInteraction000550370
      WBInteraction000550374
      WBInteraction000555853
      WBInteraction000562626
      WBInteraction000568354
      WBInteraction000573277
      WBInteraction000576802
      WBInteraction000576803
      WBInteraction000579005
      WBInteraction000579006
      WBInteraction000579007
      WBInteraction000583895
      WBInteraction000584134
    WBProcess: WBbiopr:00000001
      WBbiopr:00000008
      WBbiopr:00000014
      WBbiopr:00000039
  Map_info: Map: III Position: -4.2469 Error: 0.000352
    Positive: Positive_clone: F13B10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4791
        5662
      Pos_neg_data: 10953
        10954
        10955
    Pseudo_map_position
  Reference (122)
  Picture: WBPicture0000013079
    WBPicture0000013081
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene