WormBase Tree Display for Gene: WBGene00004800

WBGene00004800 SMap: S_parent: Sequence: R11A8
  Identity: Version: 1
    Name: CGC_name: sir-2.1 Person_evidence: WBPerson1840
      Sequence_name: R11A8.4
      Molecular_name: R11A8.4a
        R11A8.4a.1
        CE06302
        R11A8.4b
        CE44629
        R11A8.4b.1
      Other_name: CELE_R11A8.4 Accession_evidence: NDB BX284604
      Public_name: sir-2.1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sir
    Allele (42)
    Strain (5)
    RNASeq_FPKM (74)
    GO_annotation (36)
    Contained_in_operon: CEOP4372
    Ortholog (42)
    Paralog: WBGene00014769 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00004801 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004802 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004803 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1. Paper_evidence: WBPaper00004566
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00041098
          Curator_confirmed: WBPerson324
          Date_last_updated: 21 May 2019 00:00:00
    Potential_model: DOID:9669 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:0080208 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:1826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
  Models_disease_asserted: WBDOannot00000675
  Molecular_info: Corresponding_CDS: R11A8.4a
      R11A8.4b
    Corresponding_transcript (2)
    Other_sequence (27)
    Associated_feature: WBsf652127
      WBsf230722
      WBsf230723
      WBsf230724
  Experimental_info: RNAi_result (22)
    Expr_pattern (11)
    Drives_construct (18)
    Construct_product (18)
    Regulate_expr_cluster (22)
    Antibody: WBAntibody00001101
      WBAntibody00001123
      WBAntibody00001697
      WBAntibody00001698
    Microarray_results (26)
    Expression_cluster (97)
    Interaction: WBInteraction000002964
      WBInteraction000004625
      WBInteraction000004784
      WBInteraction000004785
      WBInteraction000004786
      WBInteraction000004787
      WBInteraction000004788
      WBInteraction000005284
      WBInteraction000005285
      WBInteraction000005286
      WBInteraction000005810
      WBInteraction000005811
      WBInteraction000005812
      WBInteraction000005813
      WBInteraction000005814
      WBInteraction000005815
      WBInteraction000005816
      WBInteraction000005817
      WBInteraction000005818
      WBInteraction000008548
      WBInteraction000008549
      WBInteraction000008577
      WBInteraction000008578
      WBInteraction000008579
      WBInteraction000008580
      WBInteraction000028734
      WBInteraction000028767
      WBInteraction000033052
      WBInteraction000034297
      WBInteraction000036026
      WBInteraction000036340
      WBInteraction000036341
      WBInteraction000036342
      WBInteraction000036343
      WBInteraction000036346
      WBInteraction000039015
      WBInteraction000039016
      WBInteraction000039017
      WBInteraction000039018
      WBInteraction000044892
      WBInteraction000049205
      WBInteraction000049496
      WBInteraction000114619
      WBInteraction000122878
      WBInteraction000122879
      WBInteraction000122880
      WBInteraction000164407
      WBInteraction000164408
      WBInteraction000164409
      WBInteraction000164410
      WBInteraction000164414
      WBInteraction000164445
      WBInteraction000172114
      WBInteraction000172917
      WBInteraction000185514
      WBInteraction000193499
      WBInteraction000210327
      WBInteraction000220370
      WBInteraction000228053
      WBInteraction000240409
      WBInteraction000240418
      WBInteraction000240419
      WBInteraction000240421
      WBInteraction000240424
      WBInteraction000240425
      WBInteraction000240428
      WBInteraction000240430
      WBInteraction000240431
      WBInteraction000240434
      WBInteraction000240436
      WBInteraction000240437
      WBInteraction000240439
      WBInteraction000240443
      WBInteraction000240444
      WBInteraction000240447
      WBInteraction000240448
      WBInteraction000240451
      WBInteraction000240452
      WBInteraction000240455
      WBInteraction000240456
      WBInteraction000240459
      WBInteraction000240521
      WBInteraction000240522
      WBInteraction000240523
      WBInteraction000240524
      WBInteraction000240525
      WBInteraction000240526
      WBInteraction000240527
      WBInteraction000240528
      WBInteraction000240529
      WBInteraction000248574
      WBInteraction000258545
      WBInteraction000260518
      WBInteraction000278703
      WBInteraction000295692
      WBInteraction000298509
      WBInteraction000300506
      WBInteraction000314942
      WBInteraction000329540
      WBInteraction000334702
      WBInteraction000342562
      WBInteraction000353017
      WBInteraction000355124
      WBInteraction000393139
      WBInteraction000407412
      WBInteraction000408931
      WBInteraction000411315
      WBInteraction000442904
      WBInteraction000445356
      WBInteraction000446552
      WBInteraction000461162
      WBInteraction000464785
      WBInteraction000470209
      WBInteraction000471884
      WBInteraction000475097
      WBInteraction000500350
      WBInteraction000502251
      WBInteraction000502252
      WBInteraction000502253
      WBInteraction000502254
      WBInteraction000502255
      WBInteraction000502256
      WBInteraction000502257
      WBInteraction000502258
      WBInteraction000502259
      WBInteraction000502260
      WBInteraction000502388
      WBInteraction000502767
      WBInteraction000504093
      WBInteraction000504094
      WBInteraction000504095
      WBInteraction000504439
      WBInteraction000504441
      WBInteraction000504442
      WBInteraction000537068
      WBInteraction000537069
      WBInteraction000537084
      WBInteraction000540645
      WBInteraction000540728
      WBInteraction000540747
      WBInteraction000540750
      WBInteraction000540915
      WBInteraction000540959
      WBInteraction000540960
      WBInteraction000541590
      WBInteraction000541769
      WBInteraction000543025
      WBInteraction000550015
      WBInteraction000556321
      WBInteraction000556322
      WBInteraction000556350
      WBInteraction000558079
      WBInteraction000558080
      WBInteraction000558081
      WBInteraction000574187
      WBInteraction000574573
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: IV Position: 4.57839 Error: 0.000393
    Positive: Positive_clone: R11A8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4660
    Pseudo_map_position
  Reference (245)
  Remark: Sequence connection from [Tissenbaum HA]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene