WormBase Tree Display for Gene: WBGene00004014

WBGene00004014 SMap: S_parent: Sequence: Y37E3
  Identity: Version: 1
    Name: CGC_name: phb-1 Person_evidence: WBPerson364
      Sequence_name: Y37E3.9
      Molecular_name: Y37E3.9
        Y37E3.9.1
        CE26775
      Other_name: CELE_Y37E3.9 Accession_evidence: NDB BX284601
      Public_name: phb-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: phb
    Allele (26)
    RNASeq_FPKM (74)
    GO_annotation (19)
    Contained_in_operon: CEOP1036
    Ortholog (37)
    Paralog: WBGene00004015 Caenorhabditis elegans From_analysis (2)
    Structured_description: Concise_description: phb-1 encodes the C. elegans ortholog of prohibitin PHB1; loss of phb-1 activity via RNAi indicates that phb-1 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-1, along with prohibitin subunit PHB-2, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products. Paper_evidence: WBPaper00006039
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Dec 2010 00:00:00
      Automated_description: Involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion morphogenesis. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in several structures, including body wall musculature; excretory canal; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate carcinoma in situ; and sporadic breast cancer. Is an ortholog of human PHB1 (prohibitin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8991 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8912)
      DOID:8634 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8912)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8912)
      DOID:8029 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8912)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8912)
  Molecular_info: Corresponding_CDS: Y37E3.9
    Corresponding_transcript: Y37E3.9.1
    Other_sequence (132)
    Associated_feature: WBsf654771
      WBsf656007
      WBsf980953
      WBsf217273
  Experimental_info: RNAi_result (121)
    Expr_pattern: Expr8823
      Expr1014089
      Expr1031921
      Expr1159459
      Expr2014888
      Expr2033123
    Drives_construct: WBCnstr00013545
    Construct_product: WBCnstr00013545
    Microarray_results (17)
    Expression_cluster (150)
    Interaction: WBInteraction000047328
      WBInteraction000103810
      WBInteraction000122451
      WBInteraction000134379
      WBInteraction000137011
      WBInteraction000145556
      WBInteraction000147292
      WBInteraction000149726
      WBInteraction000157256
      WBInteraction000158052
      WBInteraction000158931
      WBInteraction000159503
      WBInteraction000159775
      WBInteraction000162312
      WBInteraction000162476
      WBInteraction000162944
      WBInteraction000162956
      WBInteraction000164892
      WBInteraction000170111
      WBInteraction000170572
      WBInteraction000170573
      WBInteraction000172029
      WBInteraction000174674
      WBInteraction000180889
      WBInteraction000182802
      WBInteraction000185380
      WBInteraction000185589
      WBInteraction000191169
      WBInteraction000198712
      WBInteraction000214802
      WBInteraction000216975
      WBInteraction000234095
      WBInteraction000237498
      WBInteraction000244365
      WBInteraction000247539
      WBInteraction000249689
      WBInteraction000250171
      WBInteraction000250178
      WBInteraction000250240
      WBInteraction000250243
      WBInteraction000261437
      WBInteraction000266894
      WBInteraction000268004
      WBInteraction000306106
      WBInteraction000313086
      WBInteraction000314465
      WBInteraction000317528
      WBInteraction000323004
      WBInteraction000334702
      WBInteraction000341031
      WBInteraction000341048
      WBInteraction000348476
      WBInteraction000354154
      WBInteraction000363468
      WBInteraction000372785
      WBInteraction000379644
      WBInteraction000393918
      WBInteraction000396244
      WBInteraction000399874
      WBInteraction000399987
      WBInteraction000426265
      WBInteraction000429110
      WBInteraction000438429
      WBInteraction000441707
      WBInteraction000442723
      WBInteraction000442977
      WBInteraction000445450
      WBInteraction000447585
      WBInteraction000463738
      WBInteraction000463743
      WBInteraction000464911
      WBInteraction000466613
      WBInteraction000466614
      WBInteraction000468699
      WBInteraction000470581
      WBInteraction000472188
      WBInteraction000472657
      WBInteraction000473929
      WBInteraction000474300
      WBInteraction000522931
      WBInteraction000524875
      WBInteraction000524877
      WBInteraction000524888
      WBInteraction000524890
      WBInteraction000524892
      WBInteraction000524894
      WBInteraction000524896
      WBInteraction000524898
      WBInteraction000524900
      WBInteraction000524902
      WBInteraction000524904
      WBInteraction000524906
      WBInteraction000524908
      WBInteraction000524914
      WBInteraction000524916
      WBInteraction000524918
      WBInteraction000524920
      WBInteraction000524922
      WBInteraction000524924
      WBInteraction000524926
      WBInteraction000537332
      WBInteraction000537334
      WBInteraction000537336
      WBInteraction000537339
      WBInteraction000537341
      WBInteraction000537343
      WBInteraction000537346
      WBInteraction000537353
      WBInteraction000537355
      WBInteraction000537357
      WBInteraction000537358
      WBInteraction000537361
      WBInteraction000537363
      WBInteraction000537368
      WBInteraction000537369
      WBInteraction000537370
      WBInteraction000537371
      WBInteraction000539022
      WBInteraction000540316
      WBInteraction000540475
      WBInteraction000552658
      WBInteraction000554136
      WBInteraction000560913
      WBInteraction000562124
      WBInteraction000562378
      WBInteraction000562473
      WBInteraction000562788
      WBInteraction000566440
      WBInteraction000566719
      WBInteraction000567002
      WBInteraction000567037
      WBInteraction000568655
      WBInteraction000569423
      WBInteraction000569633
      WBInteraction000572404
      WBInteraction000572496
      WBInteraction000572918
      WBInteraction000581998
      WBInteraction000585989
  Map_info: Map: I Position: -11.8948 Error: 0.038996
    Positive: Positive_clone: Y37E3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene