WormBase Tree Display for Gene: WBGene00002227

WBGene00002227 SMap: S_parent: Sequence: W02B12
  Identity: Version: 2
    Name: CGC_name: klp-17 Person_evidence: WBPerson589
      Sequence_name: W02B12.7
      Molecular_name: W02B12.7
        W02B12.7.1
        CE37934
      Other_name: CELE_W02B12.7 Accession_evidence: NDB BX284602
      Public_name: klp-17
    DB_info: Database: AceView gene 2L756
        WormQTL gene WBGene00002227
        WormFlux gene WBGene00002227
        NDB locus_tag CELE_W02B12.7
        Panther gene CAEEL|WormBase=WBGene00002227|UniProtKB=Q23124
          family PTHR47972
        NCBI gene 174750
        RefSeq protein NM_064045.6
        TREEFAM TREEFAM_ID TF320932
        TrEMBL UniProtAcc Q23124
        UniProt_GCRP UniProtAcc Q23124
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: klp
    Allele (33)
    Possibly_affected_by: WBVar02153214
    Strain: WBStrain00032128
      WBStrain00024311
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (24)
    Paralog (19)
    Structured_description: Concise_description: klp-17 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; by homology, KLP-17 is predicted to function as a minus-end directed motor; loss of klp-17 activity via RNAi results in embryonic lethality generally at the one- or two-cell stage with disorganized mitotic spindles and polyploid nuclei, suggesting that KLP-17 plays a role in chromosome segregation and germline development; in situ hybridization studies reveal that klp-17 mRNA is localized specifically to cell nuclei during early development, from the one-cell stage of embryogenesis until early larval stages; a klp-17::gfp transgene did not yield detectable GFP expression, but did result in a small percentage of morphologically abnormal males and intersexual animals that grew slowly and died upon reaching maturity, consistent with a role for klp-17 in chromosome dynamics. Paper_evidence: WBPaper00003893
            WBPaper00003965
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Nov 2005 00:00:00
      Automated_description: Predicted to enable microtubule binding activity. Involved in chromosome segregation. Predicted to be located in microtubule cytoskeleton. Expressed in germ line and sperm. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W02B12.7
    Corresponding_CDS_history: W02B12.7:wp137
    Corresponding_transcript: W02B12.7.1
    Other_sequence: Tcir_isotig17190
      XI03693
      FD517427.1
      Tcir_isotig27917
      CSC02222_1
    Associated_feature: WBsf223939
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr982
      Expr1101
      Expr15130
      Expr1023203
      Expr1158108
      Expr2012960
      Expr2031192
    Drives_construct: WBCnstr00036372
    Construct_product: WBCnstr00036372
    Microarray_results (20)
    Expression_cluster (109)
    Interaction: WBInteraction000009770
      WBInteraction000009804
      WBInteraction000033290
      WBInteraction000033291
      WBInteraction000033374
      WBInteraction000033676
      WBInteraction000033918
      WBInteraction000035926
      WBInteraction000036392
      WBInteraction000036394
      WBInteraction000036805
      WBInteraction000036951
      WBInteraction000036953
      WBInteraction000039144
      WBInteraction000039517
      WBInteraction000043331
      WBInteraction000043396
      WBInteraction000043397
      WBInteraction000043802
      WBInteraction000045631
      WBInteraction000045632
      WBInteraction000045752
      WBInteraction000045753
      WBInteraction000045763
      WBInteraction000045946
      WBInteraction000047138
      WBInteraction000047402
      WBInteraction000047403
      WBInteraction000047404
      WBInteraction000126577
      WBInteraction000135552
      WBInteraction000135553
      WBInteraction000265848
      WBInteraction000273871
      WBInteraction000319611
      WBInteraction000348494
      WBInteraction000378352
      WBInteraction000386886
      WBInteraction000387390
      WBInteraction000399415
      WBInteraction000430806
      WBInteraction000456995
      WBInteraction000585714
  Map_info: Map: II Position: 3.49314 Error: 0.002649
    Positive: Positive_clone: W02B12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4466
    Pseudo_map_position
  Reference: WBPaper00003893
    WBPaper00003965
    WBPaper00005076
    WBPaper00015680
    WBPaper00015683
    WBPaper00022947
    WBPaper00025098
    WBPaper00038491
    WBPaper00055090
    WBPaper00064797
  Remark: Sequence connection from [Siddiqui SS], [krb 020711]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene