WormBase Tree Display for Gene: WBGene00001953

WBGene00001953 SMap: S_parent: Sequence: C02B8
  Identity: Version: 1
    Name: CGC_name: hlh-8 Person_evidence: WBPerson346
      Sequence_name: C02B8.4
      Molecular_name: C02B8.4
        C02B8.4.1
        CE24777
        C02B8.4.2
      Other_name: CELE_C02B8.4 Accession_evidence: NDB BX284606
      Public_name: hlh-8
    DB_info: Database: AceView gene XI737
        WormQTL gene WBGene00001953
        WormFlux gene WBGene00001953
        OMIM disease 101400
          gene 601622
            607556
        NDB locus_tag CELE_C02B8.4
        Panther gene CAEEL|WormBase=WBGene00001953|UniProtKB=Q11094
          family PTHR23349
        NCBI gene 181069
        RefSeq protein NM_076966.3
        SwissProt UniProtAcc Q11094
        UniProt_GCRP UniProtAcc Q11094
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hlh
    Allele (88)
    Strain: WBStrain00027639
      WBStrain00027640
      WBStrain00030584
      WBStrain00030587
      WBStrain00030588
      WBStrain00033322
      WBStrain00037705
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (37)
    Paralog: WBGene00000561 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00001954 Caenorhabditis elegans From_analysis: Panther
      WBGene00001957 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003595 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00001962 Caenorhabditis elegans From_analysis: Panther
      WBGene00001981 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001956 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. Paper_evidence: WBPaper00003174
            WBPaper00004154
            WBPaper00004482
            WBPaper00005080
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and vulval cell fate specification. Predicted to be located in nucleus. Expressed in several structures, including M.dla; M.dra; M.vla; body wall muscle cell from M lineage; and enteric muscle. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in several diseases, including Barber-Say syndrome; Sweeney-Cox syndrome; and synostosis (multiple). Is an ortholog of human TWIST2 (twist family bHLH transcription factor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info (3)
  Models_disease_in_annotation: WBDOannot00001006
  Models_disease_asserted: WBDOannot00000126
    WBDOannot00001005
  Molecular_info: Corresponding_CDS: C02B8.4
    Corresponding_transcript: C02B8.4.1
      C02B8.4.2
    Other_sequence: Oden_isotig22148
      ES413014.1
      JI213846.1
    Associated_feature (14)
    Gene_product_binds (7249)
    Transcription_factor: WBTranscriptionFactor000066
      WBTranscriptionFactor000083
  Experimental_info: RNAi_result (14)
    Expr_pattern (13)
    Drives_construct (19)
    Construct_product (11)
    Antibody: WBAntibody00000188
      WBAntibody00001852
    Microarray_results (19)
    Expression_cluster (88)
    Interaction: WBInteraction000000693
      WBInteraction000003186
      WBInteraction000003320
      WBInteraction000003321
      WBInteraction000003322
      WBInteraction000003960
      WBInteraction000003961
      WBInteraction000003966
      WBInteraction000006528
      WBInteraction000007911
      WBInteraction000009477
      WBInteraction000009614
      WBInteraction000028381
      WBInteraction000028666
      WBInteraction000028718
      WBInteraction000029179
      WBInteraction000029729
      WBInteraction000033278
      WBInteraction000035147
      WBInteraction000038691
      WBInteraction000040858
      WBInteraction000042489
      WBInteraction000042658
      WBInteraction000047500
      WBInteraction000047916
      WBInteraction000048419
      WBInteraction000048693
      WBInteraction000048707
      WBInteraction000049921
      WBInteraction000050487
      WBInteraction000110099
      WBInteraction000119107
      WBInteraction000126004
      WBInteraction000133523
      WBInteraction000134695
      WBInteraction000141429
      WBInteraction000147896
      WBInteraction000151139
      WBInteraction000165135
      WBInteraction000165136
      WBInteraction000165859
      WBInteraction000165860
      WBInteraction000165861
      WBInteraction000171446
      WBInteraction000194449
      WBInteraction000202330
      WBInteraction000206950
      WBInteraction000209269
      WBInteraction000212216
      WBInteraction000212751
      WBInteraction000221494
      WBInteraction000230228
      WBInteraction000244389
      WBInteraction000244682
      WBInteraction000252020
      WBInteraction000271182
      WBInteraction000273844
      WBInteraction000308507
      WBInteraction000323472
      WBInteraction000324073
      WBInteraction000325954
      WBInteraction000333274
      WBInteraction000336467
      WBInteraction000346876
      WBInteraction000366247
      WBInteraction000372880
      WBInteraction000399792
      WBInteraction000400130
      WBInteraction000404612
      WBInteraction000410455
      WBInteraction000410467
      WBInteraction000448849
      WBInteraction000454486
      WBInteraction000456513
      WBInteraction000458807
      WBInteraction000459553
      WBInteraction000501408
      WBInteraction000501764
      WBInteraction000502322
      WBInteraction000502323
      WBInteraction000502324
      WBInteraction000502325
      WBInteraction000502326
      WBInteraction000502327
      WBInteraction000502328
      WBInteraction000502329
      WBInteraction000502330
      WBInteraction000502331
      WBInteraction000502724
      WBInteraction000502842
      WBInteraction000502843
      WBInteraction000504023
      WBInteraction000505178
      WBInteraction000520219
      WBInteraction000520220
      WBInteraction000520221
      WBInteraction000520222
      WBInteraction000521683
      WBInteraction000521684
      WBInteraction000521685
      WBInteraction000523895
      WBInteraction000524082
      WBInteraction000526349
      WBInteraction000540866
      WBInteraction000540867
      WBInteraction000540868
      WBInteraction000540869
      WBInteraction000540870
      WBInteraction000540871
      WBInteraction000542652
      WBInteraction000542653
      WBInteraction000547059
      WBInteraction000554882
      WBInteraction000555661
      WBInteraction000555942
      WBInteraction000557656
      WBInteraction000557657
      WBInteraction000557658
      WBInteraction000557659
      WBInteraction000557660
      WBInteraction000560757
    WBProcess: WBbiopr:00000040
  Map_info: Map: X Position: -0.530654 Error: 0.011006
    Positive: Positive_clone: C02B8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4404
        4750
        4876
        5663
    Pseudo_map_position
  Reference (71)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene