WormBase Tree Display for Gene: WBGene00001500

WBGene00001500 SMap: S_parent: Sequence: C54F6
  Identity: Version: 1
    Name: CGC_name: ftn-1
      Sequence_name: C54F6.14
      Molecular_name: C54F6.14
        C54F6.14.1
        CE48091
      Other_name: CELE_C54F6.14 Accession_evidence: NDB BX284605
      Public_name: ftn-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ftn
    Allele (31)
    Strain: WBStrain00033278
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (69)
    Paralog: WBGene00001501 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: ftn-1 encodes one of two C. elegans ferritin heavy chain homologs; ftn-1 activity is essential for normal lifespan under iron stress conditions and, in addition, has been reported to be essential for embryogenesis; an ftn-1::gfp reporter is expressed in the intestine at all stages of development and its expression, as well as that of ftn-1 mRNA, increases under iron stress conditions and in the background of mutations in the second ferritin-encoding gene, ftn-2. Paper_evidence: WBPaper00005703
            WBPaper00024456
            WBPaper00024497
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 10 Mar 2006 00:00:00
      Automated_description: Enables identical protein binding activity. Involved in intracellular iron ion homeostasis. Predicted to be located in cytoplasm. Expressed in intestine and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegeneration with brain iron accumulation 3. Is an ortholog of human FTH1 (ferritin heavy chain 1); FTHL17 (ferritin heavy chain like 17); and FTMT (ferritin mitochondrial). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
      DOID:1289 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
      DOID:0111031 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3976)
      DOID:0080600 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3976,HGNC:3999)
      DOID:0110737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
      DOID:679 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
  Molecular_info: Corresponding_CDS: C54F6.14
    Corresponding_transcript: C54F6.14.1
    Other_sequence (18)
    Associated_feature (12)
  Experimental_info: RNAi_result (19)
    Expr_pattern (10)
    Drives_construct (20)
    Construct_product: WBCnstr00011120
      WBCnstr00014621
      WBCnstr00036908
      WBCnstr00041574
      WBCnstr00042810
      WBCnstr00042811
    Antibody: WBAntibody00002946
    Microarray_results (17)
    Expression_cluster (363)
    Interaction: WBInteraction000028655
      WBInteraction000030560
      WBInteraction000030561
      WBInteraction000030562
      WBInteraction000126514
      WBInteraction000126515
      WBInteraction000208250
      WBInteraction000212196
      WBInteraction000239194
      WBInteraction000257485
      WBInteraction000262830
      WBInteraction000278636
      WBInteraction000283917
      WBInteraction000293903
      WBInteraction000305879
      WBInteraction000307685
      WBInteraction000311293
      WBInteraction000317401
      WBInteraction000317438
      WBInteraction000321963
      WBInteraction000329000
      WBInteraction000332464
      WBInteraction000332820
      WBInteraction000335726
      WBInteraction000345548
      WBInteraction000349520
      WBInteraction000354425
      WBInteraction000355776
      WBInteraction000355973
      WBInteraction000365317
      WBInteraction000368207
      WBInteraction000383086
      WBInteraction000385444
      WBInteraction000388577
      WBInteraction000389367
      WBInteraction000394386
      WBInteraction000409151
      WBInteraction000409690
      WBInteraction000409949
      WBInteraction000422154
      WBInteraction000433305
      WBInteraction000434892
      WBInteraction000435276
      WBInteraction000435875
      WBInteraction000441961
      WBInteraction000446958
      WBInteraction000454931
      WBInteraction000501831
      WBInteraction000502738
      WBInteraction000502739
      WBInteraction000503404
      WBInteraction000504247
      WBInteraction000504937
      WBInteraction000505194
      WBInteraction000506636
      WBInteraction000506637
      WBInteraction000506638
      WBInteraction000506639
      WBInteraction000506640
      WBInteraction000506641
      WBInteraction000506642
      WBInteraction000506643
      WBInteraction000506644
      WBInteraction000506645
      WBInteraction000506646
      WBInteraction000506647
      WBInteraction000506648
      WBInteraction000506649
      WBInteraction000506650
      WBInteraction000506651
      WBInteraction000506652
      WBInteraction000506653
      WBInteraction000506654
      WBInteraction000506655
      WBInteraction000506656
      WBInteraction000506657
      WBInteraction000506658
      WBInteraction000506659
      WBInteraction000506660
      WBInteraction000506666
      WBInteraction000506667
      WBInteraction000506670
      WBInteraction000507870
      WBInteraction000507871
      WBInteraction000507873
      WBInteraction000507882
      WBInteraction000507884
      WBInteraction000507885
      WBInteraction000507890
      WBInteraction000507897
      WBInteraction000507903
      WBInteraction000507915
      WBInteraction000507916
      WBInteraction000507920
      WBInteraction000512432
      WBInteraction000512433
      WBInteraction000512434
      WBInteraction000512435
      WBInteraction000512436
      WBInteraction000512437
      WBInteraction000512438
      WBInteraction000512439
      WBInteraction000512440
      WBInteraction000512441
      WBInteraction000512442
      WBInteraction000512443
      WBInteraction000512444
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      WBInteraction000512446
      WBInteraction000512447
      WBInteraction000512448
      WBInteraction000512449
      WBInteraction000512450
      WBInteraction000512451
      WBInteraction000512452
      WBInteraction000512453
      WBInteraction000512454
      WBInteraction000512455
      WBInteraction000512456
      WBInteraction000512457
      WBInteraction000512458
      WBInteraction000512459
      WBInteraction000512460
      WBInteraction000512461
      WBInteraction000512462
      WBInteraction000512463
      WBInteraction000512464
      WBInteraction000512465
      WBInteraction000512466
      WBInteraction000512467
      WBInteraction000517422
      WBInteraction000517424
      WBInteraction000517425
      WBInteraction000517426
      WBInteraction000517922
      WBInteraction000519847
      WBInteraction000519859
      WBInteraction000519860
      WBInteraction000519861
      WBInteraction000519862
      WBInteraction000519863
      WBInteraction000519864
      WBInteraction000519865
      WBInteraction000519867
      WBInteraction000519868
      WBInteraction000519869
      WBInteraction000519870
      WBInteraction000519871
      WBInteraction000519872
      WBInteraction000519873
      WBInteraction000519874
      WBInteraction000519875
      WBInteraction000519876
      WBInteraction000519877
      WBInteraction000519878
      WBInteraction000519879
      WBInteraction000519880
      WBInteraction000519881
      WBInteraction000519882
      WBInteraction000519883
      WBInteraction000519884
      WBInteraction000519885
      WBInteraction000519886
      WBInteraction000519911
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      WBInteraction000519913
      WBInteraction000519914
      WBInteraction000519915
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      WBInteraction000519919
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      WBInteraction000519928
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      WBInteraction000519937
      WBInteraction000519938
      WBInteraction000519952
      WBInteraction000520290
      WBInteraction000520292
      WBInteraction000520294
      WBInteraction000520296
      WBInteraction000520297
      WBInteraction000520444
      WBInteraction000521286
      WBInteraction000521287
      WBInteraction000521658
      WBInteraction000521659
      WBInteraction000524096
      WBInteraction000524097
      WBInteraction000524098
      WBInteraction000524518
      WBInteraction000524541
      WBInteraction000524542
      WBInteraction000524543
      WBInteraction000524544
      WBInteraction000547594
      WBInteraction000547595
      WBInteraction000547596
      WBInteraction000551811
      WBInteraction000561513
      WBInteraction000586227
      WBInteraction000586229
    WBProcess: WBbiopr:00000096
  Map_info: Map: V Position: 0.786806 Error: 0.005591
    Positive: Positive_clone: C54F6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (42)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene