WormBase Tree Display for Gene: WBGene00000883

WBGene00000883 SMap: S_parent: Sequence: Y75B12B
  Identity: Version: 2
    Name: CGC_name: cyn-7 Person_evidence: WBPerson466
      Sequence_name: Y75B12B.2
      Molecular_name: Y75B12B.2
        Y75B12B.2.1
        CE20371
      Other_name: cyp-7 Person_evidence: WBPerson466
        CELE_Y75B12B.2 Accession_evidence: NDB BX284605
      Public_name: cyn-7
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Sep 2004 16:20:03 WBPerson1971 Name_change: CGC_name: cyp-7 -> cyn-7
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyn
    Allele (26)
    Legacy_information: [C.elegansII] NMK. Cyclophilin family. Signal peptide. [TP]
    Strain: WBStrain00032910
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (63)
    Paralog (18)
    Structured_description: Concise_description: cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays. Paper_evidence: WBPaper00002472
            WBPaper00004651
            WBPaper00026884
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 20 Mar 2007 00:00:00
      Automated_description: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:1474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:12506 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
  Molecular_info: Corresponding_CDS: Y75B12B.2
    Corresponding_transcript: Y75B12B.2.1
    Other_sequence (63)
    Associated_feature: WBsf653438
      WBsf653439
      WBsf977373
      WBsf977374
      WBsf235037
  Experimental_info: RNAi_result: WBRNAi00111702 Inferred_automatically: RNAi_primary
      WBRNAi00001940 Inferred_automatically: RNAi_primary
      WBRNAi00058420 Inferred_automatically: RNAi_primary
      WBRNAi00027817 Inferred_automatically: RNAi_primary
      WBRNAi00083853 Inferred_automatically: RNAi_primary
      WBRNAi00083670 Inferred_automatically: RNAi_primary
      WBRNAi00021427 Inferred_automatically: RNAi_primary
      WBRNAi00076846 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1064
      Expr1022229
      Expr1030548
      Expr1161841
      Expr2010675
      Expr2028915
    Drives_construct: WBCnstr00037223
    Construct_product: WBCnstr00037223
    Microarray_results (22)
    Expression_cluster (195)
    Interaction: WBInteraction000029864
      WBInteraction000037120
      WBInteraction000037124
      WBInteraction000037127
      WBInteraction000037128
      WBInteraction000037129
      WBInteraction000037673
      WBInteraction000042029
      WBInteraction000042030
      WBInteraction000042031
      WBInteraction000042032
      WBInteraction000043242
      WBInteraction000043243
      WBInteraction000043244
      WBInteraction000043245
      WBInteraction000043246
      WBInteraction000043438
      WBInteraction000044483
      WBInteraction000044484
      WBInteraction000045542
      WBInteraction000046762
      WBInteraction000048837
      WBInteraction000049351
      WBInteraction000049352
      WBInteraction000124200
      WBInteraction000153291
      WBInteraction000157025
      WBInteraction000157060
      WBInteraction000157962
      WBInteraction000157967
      WBInteraction000158360
      WBInteraction000159055
      WBInteraction000159067
      WBInteraction000159073
      WBInteraction000159088
      WBInteraction000159134
      WBInteraction000159357
      WBInteraction000159473
      WBInteraction000169944
      WBInteraction000174503
      WBInteraction000183658
      WBInteraction000185418
      WBInteraction000185872
      WBInteraction000186504
      WBInteraction000190418
      WBInteraction000195751
      WBInteraction000201566
      WBInteraction000214375
      WBInteraction000214376
      WBInteraction000218416
      WBInteraction000221798
      WBInteraction000224567
      WBInteraction000225478
      WBInteraction000231306
      WBInteraction000231608
      WBInteraction000247175
      WBInteraction000252161
      WBInteraction000255510
      WBInteraction000257036
      WBInteraction000258916
      WBInteraction000259138
      WBInteraction000268424
      WBInteraction000276777
      WBInteraction000281456
      WBInteraction000294118
      WBInteraction000295466
      WBInteraction000312416
      WBInteraction000314698
      WBInteraction000320089
      WBInteraction000324810
      WBInteraction000325337
      WBInteraction000337788
      WBInteraction000340863
      WBInteraction000340870
      WBInteraction000341119
      WBInteraction000341139
      WBInteraction000341167
      WBInteraction000341381
      WBInteraction000346874
      WBInteraction000349953
      WBInteraction000355290
      WBInteraction000358812
      WBInteraction000370253
      WBInteraction000375177
      WBInteraction000379835
      WBInteraction000380496
      WBInteraction000381773
      WBInteraction000387375
      WBInteraction000389462
      WBInteraction000402587
      WBInteraction000403683
      WBInteraction000405008
      WBInteraction000406495
      WBInteraction000407374
      WBInteraction000409364
      WBInteraction000411994
      WBInteraction000412114
      WBInteraction000415164
      WBInteraction000422389
      WBInteraction000425153
      WBInteraction000433867
      WBInteraction000435797
      WBInteraction000441306
      WBInteraction000441307
      WBInteraction000441308
      WBInteraction000441309
      WBInteraction000441310
      WBInteraction000441311
      WBInteraction000444993
      WBInteraction000449120
      WBInteraction000450205
      WBInteraction000450260
      WBInteraction000455647
      WBInteraction000458215
      WBInteraction000458216
      WBInteraction000458217
      WBInteraction000458218
      WBInteraction000458219
      WBInteraction000459544
      WBInteraction000460596
      WBInteraction000463215
      WBInteraction000463572
      WBInteraction000464141
      WBInteraction000464881
      WBInteraction000465155
      WBInteraction000465156
      WBInteraction000465157
      WBInteraction000465158
      WBInteraction000468817
      WBInteraction000468959
      WBInteraction000469976
      WBInteraction000470743
      WBInteraction000471627
      WBInteraction000471628
      WBInteraction000471814
      WBInteraction000472092
      WBInteraction000472114
      WBInteraction000472874
      WBInteraction000473582
      WBInteraction000474859
      WBInteraction000474977
      WBInteraction000475332
      WBInteraction000536825
      WBInteraction000553135
      WBInteraction000555046
      WBInteraction000555877
      WBInteraction000561797
      WBInteraction000562052
      WBInteraction000563750
      WBInteraction000565075
      WBInteraction000565104
      WBInteraction000566406
      WBInteraction000566685
      WBInteraction000569357
      WBInteraction000570794
      WBInteraction000571120
      WBInteraction000572121
      WBInteraction000572959
      WBInteraction000573390
      WBInteraction000576555
      WBInteraction000577526
      WBInteraction000579931
      WBInteraction000582533
      WBInteraction000585432
      WBInteraction000586514
  Map_info: Map: V Position: 7.51429 Error: 0.006122
    Positive: Positive_clone (2)
    Pseudo_map_position
  Reference (11)
  Remark: signal_peptide
    [Page AM] From partial Est sequence CEESN11F. Is transpliced by SL-1. Isolated from mixed stage cDNA using SL1, and known 3' seq from CEESN11F.
    [Page AM] Have been unable to accurately map this gene to the YAC grid- as it cross-hybridises with the other highly homologous gene.
    PPIase or cyclophilin, EC 5.2.1.8
    This gene has been renamed with approval of the CGC (cyp-7->cyn-7) Person_evidence: WBPerson466
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene