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WormBase Tree Display for Gene: WBGene00000591

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Name Class

WBGene00000591EvidenceCGC_data_submission
SMapS_parentSequenceK08A8
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classcoh
Allele (159)
Legacy_informationParalogue of S.pombe rad21
[J. Loidl] RNAi phenotypes\: ~80% embryo lethality, HIM (~2% males); protein localizes to somatic nuclei of the embryo and the distal tip cell of the gonad
(K08A8.3) is homolog to the Rad21/Scc1/Rec8 family of cohesion proteins with known members in S. cerevisiae, S. pombe, A. thaliana and vertebrates. R-S-R is the acronym of the founder family
RNASeq_FPKM (74)
GO_annotation00001983
00001984
00001985
00001986
00001991
00001992
00107606
00107607
Ortholog (36)
ParalogWBGene00004737Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
Structured_descriptionConcise_descriptioncoh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells; expressed in the distal tip cells of the gonad, embryonic, and somatic cellsPaper_evidenceWBPaper00004722
Curator_confirmedWBPerson48
Date_last_updated09 Aug 2004 00:00:00
Automated_descriptionPredicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of cohesin complex. Expressed in several structures, including anterior distal tip cell; anterior gonad arm; germ line; and posterior distal tip cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080508Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:0080199Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:1380Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
Molecular_infoCorresponding_CDSK08A8.3a
K08A8.3b
K08A8.3c
K08A8.3d
Corresponding_CDS_historyK08A8.3:wp252
Corresponding_transcriptK08A8.3a.1
K08A8.3b.1
K08A8.3c.1
K08A8.3d.1
Other_sequence (18)
Associated_featureWBsf670724
WBsf1005848
WBsf1005849
WBsf1005850
WBsf1005851
WBsf1005852
WBsf1023254
WBsf1023255
WBsf1023256
WBsf1023257
Experimental_infoRNAi_result (14)
Expr_patternExpr1349
Expr2580
Expr13113
Expr1026085
Expr1030346
Expr1153915
Expr2010297
Expr2028539
Drives_constructWBCnstr00037443
Construct_productWBCnstr00037443
AntibodyWBAntibody00000372
WBAntibody00000643
WBAntibody00000644
Microarray_results (26)
Expression_cluster (120)
InteractionWBInteraction000033164
WBInteraction000033579
WBInteraction000034296
WBInteraction000034312
WBInteraction000035612
WBInteraction000035800
WBInteraction000036069
WBInteraction000037385
WBInteraction000037732
WBInteraction000038103
WBInteraction000038336
WBInteraction000038923
WBInteraction000038996
WBInteraction000038997
WBInteraction000038998
WBInteraction000039894
WBInteraction000040147
WBInteraction000041933
WBInteraction000042813
WBInteraction000042968
WBInteraction000046377
WBInteraction000047195
WBInteraction000047300
WBInteraction000047332
WBInteraction000048810
WBInteraction000048811
WBInteraction000102718
WBInteraction000103240
WBInteraction000106296
WBInteraction000113338
WBInteraction000115096
WBInteraction000125828
WBInteraction000127541
WBInteraction000133182
WBInteraction000133978
WBInteraction000134099
WBInteraction000136547
WBInteraction000138226
WBInteraction000140915
WBInteraction000143647
WBInteraction000166836
WBInteraction000171604
WBInteraction000174824
WBInteraction000175962
WBInteraction000177538
WBInteraction000185109
WBInteraction000185675
WBInteraction000189825
WBInteraction000190505
WBInteraction000191129
WBInteraction000218501
WBInteraction000225947
WBInteraction000231035
WBInteraction000254732
WBInteraction000261419
WBInteraction000262976
WBInteraction000263934
WBInteraction000276803
WBInteraction000313721
WBInteraction000336549
WBInteraction000366266
WBInteraction000389674
WBInteraction000432549
WBInteraction000437572
WBInteraction000439902
WBInteraction000445014
WBInteraction000450012
WBInteraction000450639
WBInteraction000466185
WBInteraction000469588
WBInteraction000472152
WBInteraction000472231
WBInteraction000473296
WBInteraction000473857
WBInteraction000474730
WBInteraction000474809
WBInteraction000474930
WBInteraction000558481
WBInteraction000559373
WBInteraction000565421
WBInteraction000574751
Map_infoMapXPosition-1.6802Error0.004761
PositivePositive_cloneK08A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4486
5066
5498
Pseudo_map_position
ReferenceWBPaper00005937
WBPaper00012000
WBPaper00018377
WBPaper00026804
WBPaper00027033
WBPaper00031300
WBPaper00038491
WBPaper00055090
RemarkSequence connection from [Sugimoto A]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene