WormBase Tree Display for Gene: WBGene00000421
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| WBGene00000421 | SMap | S_parent | Sequence | C48B4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ced-7 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C48B4.4 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | CELE_C48B4.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | ced-7 | ||||||||
| DB_info | Database | AceView | gene | 3K660 | |||||
| WormQTL | gene | WBGene00000421 | |||||||
| WormFlux | gene | WBGene00000421 | |||||||
| NDB | locus_tag | CELE_C48B4.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000421|UniProtKB=P34358 | |||||||
| family | PTHR19229 | ||||||||
| NCBI | gene | 176352 | |||||||
| RefSeq | protein | NM_066714.5 | |||||||
| NM_001026054.4 | |||||||||
| NM_001268083.3 | |||||||||
| NM_001379863.2 | |||||||||
| SwissProt | UniProtAcc | P34358 | |||||||
| TrEMBL | UniProtAcc | C0P274 | |||||||
| UniProt_GCRP | UniProtAcc | P34358 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ced | ||||||||
| Allele (150) | |||||||||
| Legacy_information | [C.elegansII] n1892 : programmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group A (ced-1,6,7); extensive maternal rescue; no gross phenotype. OA6: n1893, n1896, n1996,n1997, n1998, n2001, n2094.Cloned: encodes 191 kD protein, similarity to ABCtransporter proteins. [Ellis et al. 1991; MT; ZB] | ||||||||
| Strain (22) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (72) | |||||||||
| Paralog (4) | |||||||||
| Structured_description | Concise_description | ced-7 encodes an ATP binding cassette (ABC) transporter that is a member of the ABCA subfamily of transporter proteins; CED-7 activity is required in both apoptotic and phagocytic cells for engulfment of apoptotic cell corpses; in regulating apoptotic cell clearance, CED-7 functions upstream of CED-10/Rac, and together with CED-1 and CED-6, to mediate actin reorganization around the apoptotic cell corpse in the phagocytic cell; in regulating engulfment with CED-1 and CED-6, CED-7 acts in a pathway parallel to that of CED-2, CED-5, and CED-12; CED-7 localizes to the plasma membrane of many embryonic cells, but in larvae and adults is found in the amphid and phasmid sheath cells and the pharyngeal-intestinal valve; further, CED-7 is expressed in the Z2 and Z3 germline precursor cells and in the germline, except for sperm. | Paper_evidence | WBPaper00003091 | |||||
| WBPaper00005200 | |||||||||
| WBPaper00025002 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Mar 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C48B4.4a | |||||||
| C48B4.4b | |||||||||
| C48B4.4c | |||||||||
| C48B4.4d | |||||||||
| Corresponding_transcript | C48B4.4a.1 | ||||||||
| C48B4.4a.2 | |||||||||
| C48B4.4b.1 | |||||||||
| C48B4.4c.1 | |||||||||
| C48B4.4d.1 | |||||||||
| Other_sequence (33) | |||||||||
| Associated_feature | WBsf651383 | ||||||||
| WBsf651384 | |||||||||
| WBsf667294 | |||||||||
| WBsf667295 | |||||||||
| WBsf1015629 | |||||||||
| WBsf227320 | |||||||||
| WBsf227321 | |||||||||
| WBsf227322 | |||||||||
| WBsf227323 | |||||||||
| WBsf227324 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00029933 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00042714 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006973 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042713 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066652 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1426 | ||||||||
| Expr3316 | |||||||||
| Expr1017941 | |||||||||
| Expr1030237 | |||||||||
| Expr1146706 | |||||||||
| Expr2009851 | |||||||||
| Expr2028091 | |||||||||
| Drives_construct | WBCnstr00011312 | ||||||||
| WBCnstr00037555 | |||||||||
| Construct_product | WBCnstr00020626 | ||||||||
| WBCnstr00037555 | |||||||||
| Antibody | WBAntibody00000178 | ||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction | WBInteraction000000643 | ||||||||
| WBInteraction000001008 | |||||||||
| WBInteraction000002239 | |||||||||
| WBInteraction000002560 | |||||||||
| WBInteraction000002563 | |||||||||
| WBInteraction000002567 | |||||||||
| WBInteraction000004569 | |||||||||
| WBInteraction000004593 | |||||||||
| WBInteraction000008734 | |||||||||
| WBInteraction000008735 | |||||||||
| WBInteraction000008736 | |||||||||
| WBInteraction000029215 | |||||||||
| WBInteraction000029216 | |||||||||
| WBInteraction000030066 | |||||||||
| WBInteraction000030067 | |||||||||
| WBInteraction000052288 | |||||||||
| WBInteraction000052380 | |||||||||
| WBInteraction000052382 | |||||||||
| WBInteraction000126076 | |||||||||
| WBInteraction000126079 | |||||||||
| WBInteraction000126080 | |||||||||
| WBInteraction000126429 | |||||||||
| WBInteraction000126443 | |||||||||
| WBInteraction000126631 | |||||||||
| WBInteraction000126780 | |||||||||
| WBInteraction000127560 | |||||||||
| WBInteraction000133137 | |||||||||
| WBInteraction000133325 | |||||||||
| WBInteraction000133476 | |||||||||
| WBInteraction000133814 | |||||||||
| WBInteraction000160379 | |||||||||
| WBInteraction000165532 | |||||||||
| WBInteraction000170411 | |||||||||
| WBInteraction000259648 | |||||||||
| WBInteraction000266860 | |||||||||
| WBInteraction000306780 | |||||||||
| WBInteraction000363206 | |||||||||
| WBInteraction000412087 | |||||||||
| WBInteraction000417994 | |||||||||
| WBInteraction000449723 | |||||||||
| WBInteraction000474021 | |||||||||
| WBInteraction000502042 | |||||||||
| WBInteraction000502044 | |||||||||
| WBInteraction000517308 | |||||||||
| WBInteraction000517312 | |||||||||
| WBInteraction000517313 | |||||||||
| WBInteraction000517317 | |||||||||
| WBInteraction000517318 | |||||||||
| WBInteraction000517342 | |||||||||
| WBInteraction000518534 | |||||||||
| WBInteraction000518649 | |||||||||
| WBInteraction000520137 | |||||||||
| WBInteraction000521807 | |||||||||
| WBInteraction000524940 | |||||||||
| WBInteraction000556122 | |||||||||
| WBInteraction000556870 | |||||||||
| WBInteraction000556874 | |||||||||
| WBInteraction000557031 | |||||||||
| WBInteraction000557032 | |||||||||
| WBInteraction000557033 | |||||||||
| WBInteraction000582368 | |||||||||
| Anatomy_function | WBbtf0061 | ||||||||
| WBProcess | WBbiopr:00000013 | ||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000015 | |||||||||
| Map_info | Map | III | Position | 0.651197 | Error | 0.025749 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | tnDf2 | |||||||
| Positive_clone | C29C3 | ||||||||
| C48B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point (16) | ||||||||
| Pos_neg_data | 9446 | ||||||||
| 10531 | |||||||||
| 10535 | |||||||||
| Reference (160) | |||||||||
| Method | Gene |
