asg-1 encodes a homolog of the proton-translocating F0 ATP synthase complex subunit g; by homology, ASG-1 is predicted to function in ATP synthesis, although its precise role in ATP anabolism is not yet known; in C. elegans, asg-1 activity is required for transposon silencing in the germline, suggesting that healthy energy metabolism is necessary for this process; in addition, large-scale RNAi screens indicate that asg-1 activity is required for embryonic and germline development, normal post-embryonic growth rates, and normal body morphology.
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be located in mitochondrial membrane. Predicted to be part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human ATP5MG (ATP synthase membrane subunit g).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.