WormBase Tree Display for Gene: WBGene00002187

WBGene00002187 Evidence: Paper_evidence: WBPaper00005583
  SMap: S_parent: Sequence: T07A9
  Identity: Version: 1
    Name: CGC_name: kgb-1 Person_evidence: WBPerson57
      Sequence_name: T07A9.3
      Molecular_name: T07A9.3
        T07A9.3.1
        CE29466
        T07A9.3.2
        T07A9.3.3
      Other_name: CELE_T07A9.3 Accession_evidence: NDB BX284604
      Public_name: kgb-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kgb
    Allele (75)
    Strain (3)
    RNASeq_FPKM (74)
    GO_annotation (71)
    Ortholog (46)
    Paralog (21)
    Structured_description: Concise_description: kgb-1 encodes a serine/threonine kinase that is a member of the JNK (Jun-N-terminal kinase) subfamily of MAP (mitogen-activated protein)kinases; loss of kgb-1 activity results in temperature-sensitive sterility in hermaphrodites and males; in hermaphrodites, this sterility is associated with disorganized gonads and endomitotic oocytes that have likely failed to undergo oocyte maturation; in kgb-1 mutant males, sperm is present, but is non-functional; KGB-1 interacts in vitro with all four C. elegans germline helicases, GLH-1, -2, -3, and -4, that localize to P granules in vivo; Northern analyses indicate that kgb-1 mRNA is present in both somatic and germline tissues. Paper_evidence: WBPaper00005583
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Apr 2006 00:00:00
      Automated_description: Enables DEAD/H-box RNA helicase binding activity; JUN kinase activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including gamete generation; response to inorganic substance; and response to toxic substance. Located in cytoplasm. Expressed in several structures, including excretory cell; germ line; gonad; nerve ring; and tail ganglion. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T07A9.3
    Corresponding_transcript: T07A9.3.1
      T07A9.3.2
      T07A9.3.3
    Other_sequence (45)
    Associated_feature: WBsf667712
      WBsf667713
      WBsf667714
      WBsf229683
      WBsf229684
      WBsf229685
  Experimental_info: RNAi_result (24)
    Expr_pattern: Expr7816
      Expr12103
      Expr13915
      Expr13916
      Expr13962
      Expr1022674
      Expr1031281
      Expr1156314
      Expr2012924
      Expr2031158
    Drives_construct: WBCnstr00020193
      WBCnstr00020194
      WBCnstr00036401
      WBCnstr00040360
      WBCnstr00040480
    Construct_product: WBCnstr00020194
      WBCnstr00036401
      WBCnstr00040360
      WBCnstr00040480
    Regulate_expr_cluster: WBPaper00050448:KGB-1-induced
    Antibody: WBAntibody00000996
      WBAntibody00000997
      WBAntibody00001293
      WBAntibody00001469
    Microarray_results (18)
    Expression_cluster (154)
    Interaction: WBInteraction000003009
      WBInteraction000029778
      WBInteraction000030939
      WBInteraction000030940
      WBInteraction000030941
      WBInteraction000126587
      WBInteraction000126787
      WBInteraction000136812
      WBInteraction000136891
      WBInteraction000136935
      WBInteraction000140865
      WBInteraction000144272
      WBInteraction000150141
      WBInteraction000212169
      WBInteraction000240150
      WBInteraction000313221
      WBInteraction000315342
      WBInteraction000379626
      WBInteraction000384233
      WBInteraction000384349
      WBInteraction000404625
      WBInteraction000500979
      WBInteraction000500980
      WBInteraction000500981
      WBInteraction000503005
      WBInteraction000503795
      WBInteraction000503796
      WBInteraction000511699
      WBInteraction000511700
      WBInteraction000511702
      WBInteraction000511708
      WBInteraction000511710
      WBInteraction000511711
      WBInteraction000513463
      WBInteraction000513468
      WBInteraction000513476
      WBInteraction000513477
      WBInteraction000516348
      WBInteraction000516350
      WBInteraction000516457
      WBInteraction000516459
      WBInteraction000516461
      WBInteraction000518419
      WBInteraction000519433
      WBInteraction000519435
      WBInteraction000519436
      WBInteraction000519437
      WBInteraction000519438
      WBInteraction000519439
      WBInteraction000519440
      WBInteraction000520436
      WBInteraction000523873
      WBInteraction000524433
      WBInteraction000524435
      WBInteraction000524665
      WBInteraction000524666
      WBInteraction000524667
      WBInteraction000524668
      WBInteraction000524743
      WBInteraction000524744
      WBInteraction000524745
      WBInteraction000524756
      WBInteraction000524757
      WBInteraction000524760
      WBInteraction000524851
      WBInteraction000524852
      WBInteraction000524853
      WBInteraction000524854
      WBInteraction000524855
      WBInteraction000524856
      WBInteraction000536170
      WBInteraction000536171
      WBInteraction000536979
      WBInteraction000536980
      WBInteraction000537420
      WBInteraction000537426
      WBInteraction000537515
      WBInteraction000541010
      WBInteraction000541091
      WBInteraction000541093
      WBInteraction000541095
      WBInteraction000541097
      WBInteraction000541098
      WBInteraction000541099
      WBInteraction000541100
      WBInteraction000541102
      WBInteraction000541103
      WBInteraction000542750
      WBInteraction000542751
      WBInteraction000542752
      WBInteraction000542753
      WBInteraction000549839
      WBInteraction000549858
      WBInteraction000554725
      WBInteraction000554726
      WBInteraction000555727
      WBInteraction000556358
      WBInteraction000556528
      WBInteraction000556529
      WBInteraction000556530
      WBInteraction000556531
      WBInteraction000556816
      WBInteraction000561392
      WBInteraction000561395
      WBInteraction000565321
      WBInteraction000573286
      WBInteraction000576445
      WBInteraction000579580
      WBInteraction000584889
    WBProcess: WBbiopr:00000096
  Map_info: Map: IV Position: -26.1142 Error: 0.02485
    Positive: Positive_clone: T07A9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4370
        4454
    Pseudo_map_position
  Reference: WBPaper00005583
    WBPaper00010061
    WBPaper00010136
    WBPaper00012359
    WBPaper00012507
    WBPaper00017833
    WBPaper00018823
    WBPaper00024218
    WBPaper00024295
    WBPaper00024299
    WBPaper00024300
    WBPaper00024508
    WBPaper00025180
    WBPaper00025272
    WBPaper00025564
    WBPaper00026182
    WBPaper00027258
    WBPaper00027261
    WBPaper00027588
    WBPaper00028697
    WBPaper00030328
    WBPaper00030943
    WBPaper00031023
    WBPaper00031666
    WBPaper00031869
    WBPaper00032209
    WBPaper00033894
    WBPaper00033947
    WBPaper00034008
    WBPaper00035583
    WBPaper00035891
    WBPaper00036535
    WBPaper00036644
    WBPaper00037182
    WBPaper00037410
    WBPaper00037587
    WBPaper00037959
    WBPaper00038321
    WBPaper00038947
    WBPaper00039040
    WBPaper00039041
    WBPaper00039189
    WBPaper00040182
    WBPaper00040839
    WBPaper00040855
    WBPaper00041045
    WBPaper00041697
    WBPaper00041960
    WBPaper00042067
    WBPaper00043289
    WBPaper00043702
    WBPaper00043917
    WBPaper00045829
    WBPaper00046103
    WBPaper00046151
    WBPaper00046373
    WBPaper00047495
    WBPaper00047903
    WBPaper00049307
    WBPaper00049460
    WBPaper00049705
    WBPaper00050448
    WBPaper00051670
    WBPaper00051680
    WBPaper00052440
    WBPaper00053620
    WBPaper00055423
    WBPaper00058210
    WBPaper00058220
    WBPaper00061030
    WBPaper00061115
    WBPaper00061196
    WBPaper00061750
    WBPaper00061837
    WBPaper00062080
    WBPaper00062731
    WBPaper00063976
    WBPaper00064105
    WBPaper00064229
    WBPaper00065073
    WBPaper00065930
    WBPaper00066032
  Picture: WBPicture0000013081
  Remark: Protein interacts with GLH (germ line helicase) proteins. Deletion allele um3, 206 aa removed. Homozygotes fertile at 20C, 40% sterile at 25C, 100% sterile at 26C. Abnormal oogenesis (Emo). Sperm present but males infertile. RNAi some sterility" [CGC_data_submission][030325 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene