WormBase Tree Display for Gene: WBGene00000065

WBGene00000065 SMap: S_parent: Sequence: T04C12
  Identity: Version: 1
    Name: CGC_name: act-3 Person_evidence: WBPerson259
      Sequence_name: T04C12.4
      Molecular_name: T04C12.4
        T04C12.4.1
        CE13148
        T04C12.4.2
        T04C12.4.3
      Other_name: act1 Accession_evidence: EMBL X16796
        act3 Accession_evidence: EMBL X16798
        CELE_T04C12.4 Accession_evidence: NDB BX284605
      Public_name: act-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: act
    Allele (40)
    Strain: WBStrain00033516
      WBStrain00005465
    In_cluster: act-123
    RNASeq_FPKM (74)
    Ortholog (46)
    Paralog: WBGene00000063 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000064 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022774 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000067 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000066 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000199 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016793 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013168 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007434 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018349 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000200 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: act-3 encodes an invertebrate actin, highly similar to ACT-1, ACT-2, and ACT-4, that functions in body wall muscle; act-3 functions with two other action isoforms, act-1 and act-2, to control cytoplasmic microfilament function in the early embryo. Paper_evidence: WBPaper00000741
            WBPaper00001178
            WBPaper00001709
            WBPaper00014413
            WBPaper00027028
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 29 Mar 2007 00:00:00
      Automated_description: Expressed in gonad and head. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Human ACTB Contributes to nucleosomal DNA binding activity. Human ACTB enables several functions, including Tat protein binding activity; enzyme binding activity; and kinesin binding activity. A structural constituent of postsynaptic actin cytoskeleton. Is predicted to encode a protein with the following domains: ATPase, nucleotide binding domain; Phosphorylation site; Actin; and Actin family. Is an ortholog of human ACTB (actin beta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1588 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0081113 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:144)
      DOID:10881 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0081112 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0110550 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:144)
  Molecular_info: Corresponding_CDS: T04C12.4
    Corresponding_transcript: T04C12.4.1
      T04C12.4.2
      T04C12.4.3
    Other_sequence (48)
    Associated_feature (11)
  Experimental_info: RNAi_result (47)
    Expr_pattern: Chronogram981
      Expr4555
      Expr6598
      Expr14934
      Expr1030026
      Expr1155998
      Expr2009223
      Expr2027460
    Drives_construct: WBCnstr00002476
      WBCnstr00037758
      WBCnstr00041591
    Construct_product: WBCnstr00037758
    Antibody: WBAntibody00001783
    Microarray_results (48)
    Expression_cluster (167)
    Interaction: WBInteraction000052143
      WBInteraction000103032
      WBInteraction000103304
      WBInteraction000105341
      WBInteraction000106011
      WBInteraction000109779
      WBInteraction000110212
      WBInteraction000110588
      WBInteraction000110800
      WBInteraction000111120
      WBInteraction000112139
      WBInteraction000112346
      WBInteraction000112376
      WBInteraction000112455
      WBInteraction000112727
      WBInteraction000114327
      WBInteraction000115158
      WBInteraction000115162
      WBInteraction000116317
      WBInteraction000120292
      WBInteraction000120378
      WBInteraction000120440
      WBInteraction000121054
      WBInteraction000121115
      WBInteraction000121326
      WBInteraction000122062
      WBInteraction000122066
      WBInteraction000122506
      WBInteraction000122792
      WBInteraction000123111
      WBInteraction000124053
      WBInteraction000124231
      WBInteraction000124878
      WBInteraction000133328
      WBInteraction000134225
      WBInteraction000134724
      WBInteraction000135677
      WBInteraction000135753
      WBInteraction000136954
      WBInteraction000137226
      WBInteraction000140195
      WBInteraction000143078
      WBInteraction000143434
      WBInteraction000145963
      WBInteraction000146712
      WBInteraction000147302
      WBInteraction000147553
      WBInteraction000148525
      WBInteraction000149769
      WBInteraction000151656
      WBInteraction000151883
      WBInteraction000152434
      WBInteraction000153046
      WBInteraction000156937
      WBInteraction000157323
      WBInteraction000157847
      WBInteraction000157848
      WBInteraction000157849
      WBInteraction000157850
      WBInteraction000157851
      WBInteraction000157852
      WBInteraction000157853
      WBInteraction000157854
      WBInteraction000157855
      WBInteraction000157856
      WBInteraction000157857
      WBInteraction000157858
      WBInteraction000157859
      WBInteraction000157898
      WBInteraction000158045
      WBInteraction000158055
      WBInteraction000158063
      WBInteraction000158432
      WBInteraction000158486
      WBInteraction000158563
      WBInteraction000158835
      WBInteraction000159016
      WBInteraction000159228
      WBInteraction000159344
      WBInteraction000159463
      WBInteraction000159738
      WBInteraction000159739
      WBInteraction000159761
      WBInteraction000159765
      WBInteraction000160998
      WBInteraction000161490
      WBInteraction000162228
      WBInteraction000162528
      WBInteraction000162903
      WBInteraction000162975
      WBInteraction000163024
      WBInteraction000163676
      WBInteraction000166899
      WBInteraction000166974
      WBInteraction000167029
      WBInteraction000167142
      WBInteraction000167477
      WBInteraction000168110
      WBInteraction000169043
      WBInteraction000169044
      WBInteraction000169065
      WBInteraction000169081
      WBInteraction000169167
      WBInteraction000169174
      WBInteraction000169247
      WBInteraction000169824
      WBInteraction000169857
      WBInteraction000169896
      WBInteraction000169905
      WBInteraction000170039
      WBInteraction000170057
      WBInteraction000171962
      WBInteraction000172837
      WBInteraction000172838
      WBInteraction000172839
      WBInteraction000172840
      WBInteraction000172841
      WBInteraction000172842
      WBInteraction000172843
      WBInteraction000172844
      WBInteraction000172873
      WBInteraction000172906
      WBInteraction000173186
      WBInteraction000173190
      WBInteraction000173194
      WBInteraction000173494
      WBInteraction000173702
      WBInteraction000173929
      WBInteraction000173937
      WBInteraction000174022
      WBInteraction000174048
      WBInteraction000174227
      WBInteraction000174250
      WBInteraction000177161
      WBInteraction000178870
      WBInteraction000180675
      WBInteraction000181312
      WBInteraction000182273
      WBInteraction000185165
      WBInteraction000185176
      WBInteraction000185468
      WBInteraction000185472
      WBInteraction000185643
      WBInteraction000185667
      WBInteraction000185944
      WBInteraction000186625
      WBInteraction000187127
      WBInteraction000190215
      WBInteraction000190771
      WBInteraction000190907
      WBInteraction000191752
      WBInteraction000194233
      WBInteraction000196626
      WBInteraction000199910
      WBInteraction000201569
      WBInteraction000208740
      WBInteraction000210493
      WBInteraction000212395
      WBInteraction000213373
      WBInteraction000214933
      WBInteraction000224919
      WBInteraction000227638
      WBInteraction000230297
      WBInteraction000240569
      WBInteraction000243524
      WBInteraction000243761
      WBInteraction000246295
      WBInteraction000250083
      WBInteraction000258704
      WBInteraction000264823
      WBInteraction000264824
      WBInteraction000265472
      WBInteraction000266651
      WBInteraction000266655
      WBInteraction000268237
      WBInteraction000268389
      WBInteraction000268393
      WBInteraction000272511
      WBInteraction000286153
      WBInteraction000286157
      WBInteraction000287043
      WBInteraction000288007
      WBInteraction000288344
      WBInteraction000300778
      WBInteraction000302698
      WBInteraction000304213
      WBInteraction000305544
      WBInteraction000311953
      WBInteraction000313260
      WBInteraction000313884
      WBInteraction000324484
      WBInteraction000325132
      WBInteraction000326940
      WBInteraction000332385
      WBInteraction000334650
      WBInteraction000335701
      WBInteraction000341193
      WBInteraction000344076
      WBInteraction000345102
      WBInteraction000348121
      WBInteraction000349548
      WBInteraction000355529
      WBInteraction000358300
      WBInteraction000365809
      WBInteraction000372079
      WBInteraction000376293
      WBInteraction000386031
      WBInteraction000386032
      WBInteraction000386037
      WBInteraction000386623
      WBInteraction000387764
      WBInteraction000402673
      WBInteraction000404864
      WBInteraction000404865
      WBInteraction000404870
      WBInteraction000410823
      WBInteraction000411202
      WBInteraction000412479
      WBInteraction000419736
      WBInteraction000419785
      WBInteraction000422137
      WBInteraction000424662
      WBInteraction000436195
      WBInteraction000436668
      WBInteraction000436672
      WBInteraction000436676
      WBInteraction000436680
      WBInteraction000436684
      WBInteraction000436688
      WBInteraction000438193
      WBInteraction000438330
      WBInteraction000453118
      WBInteraction000453674
      WBInteraction000453679
      WBInteraction000454407
      WBInteraction000454408
      WBInteraction000454413
      WBInteraction000454417
      WBInteraction000454421
      WBInteraction000455311
      WBInteraction000456385
      WBInteraction000462959
      WBInteraction000463294
      WBInteraction000463368
      WBInteraction000463372
      WBInteraction000463377
      WBInteraction000464320
      WBInteraction000464398
      WBInteraction000464633
      WBInteraction000464634
      WBInteraction000464635
      WBInteraction000464636
      WBInteraction000464637
      WBInteraction000464645
      WBInteraction000464649
      WBInteraction000464653
      WBInteraction000464657
      WBInteraction000464661
      WBInteraction000464665
      WBInteraction000464669
      WBInteraction000464673
      WBInteraction000464677
      WBInteraction000464681
      WBInteraction000464685
      WBInteraction000464818
      WBInteraction000464822
      WBInteraction000464826
      WBInteraction000464830
      WBInteraction000467767
      WBInteraction000469478
      WBInteraction000469678
      WBInteraction000470243
      WBInteraction000470244
      WBInteraction000470292
      WBInteraction000470334
      WBInteraction000470416
      WBInteraction000471086
      WBInteraction000471477
      WBInteraction000472390
      WBInteraction000472436
      WBInteraction000473450
      WBInteraction000474082
      WBInteraction000474366
      WBInteraction000521499
      WBInteraction000523581
      WBInteraction000536925
      WBInteraction000536958
      WBInteraction000537030
      WBInteraction000537063
      WBInteraction000540921
      WBInteraction000555370
      WBInteraction000563620
      WBInteraction000567145
      WBInteraction000567396
      WBInteraction000573340
      WBInteraction000579839
      WBInteraction000582621
      WBInteraction000585170
  Map_info (4)
  Reference (63)
  Remark: M03F4.2 connection removed since latter is on another chromosome. [sdm 0107]
    T04C12.6 connection removed. email from JAH 0109.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene