WormBase Tree Display for Gene: WBGene00002214

WBGene00002214 SMap: S_parent: Sequence: M7
  Identity: Version: 1
    Name: CGC_name: klc-1 Person_evidence: WBPerson589
      Sequence_name: M7.2
      Molecular_name: M7.2a
        M7.2a.1
        CE23882
        M7.2b
        CE47107
        M7.2b.1
      Other_name: CELE_M7.2 Accession_evidence: NDB BX284604
      Public_name: klc-1
    DB_info: Database: AceView gene 4L849
        WormQTL gene WBGene00002214
        WormFlux gene WBGene00002214
        NDB locus_tag CELE_M7.2
        Panther gene CAEEL|WormBase=WBGene00002214|UniProtKB=H9G2T2
          family PTHR45783
        NCBI gene 178007
        RefSeq protein NM_001268605.3
            NM_001268606.4
        TrEMBL UniProtAcc H9G2T2
            Q21592
        UniProt_GCRP UniProtAcc H9G2T2
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: klc
    Allele (36)
    Legacy_information: [Siddiqui SS ] Predicted gene M7.2. Related to kinesin light chain by sequence similarity.
    Strain: WBStrain00032659
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (35)
    Paralog: WBGene00002215 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development. Paper_evidence: WBPaper00004211
            WBPaper00004540
            WBPaper00006332
            WBPaper00024617
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 May 2005 00:00:00
      Automated_description: Predicted to enable kinesin binding activity. Involved in establishment of meiotic spindle localization and polar body extrusion after meiotic divisions. Predicted to be located in cytoplasm. Predicted to be part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
      DOID:2378 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
  Molecular_info: Corresponding_CDS: M7.2a
      M7.2b
    Corresponding_transcript: M7.2a.1
      M7.2b.1
    Associated_feature: WBsf655053
      WBsf655054
      WBsf997761
      WBsf997762
      WBsf229093
      WBsf229094
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr8883
      Expr8884
      Expr1011689
      Expr1031294
      Expr1154758
      Expr2012947
      Expr2031179
    Drives_construct: WBCnstr00036382
    Construct_product: WBCnstr00013578
      WBCnstr00036382
    Antibody: WBAntibody00002083
    Microarray_results: SMD_M7.2
      SMD_M7.4
      189205_at
      A_12_P119575
      Aff_M7.2
      GPL13394_WBGene00002214
      GPL13914_M7.2
      GPL14144_M7.2_1464-1523_0.947_1_A
      GPL19516_CGZ0030429
      GPL19516_CGZ0030430
      GPL21109_M7.2a
      GPL3518_CE23882
      GPL8304_CE_WBGene00002214_A
      GPL8304_CE_WBGene00002214_B
      GPL8304_CE_WBGene00002214_C
      GPL8673_M7_2P00053
      GPL8673_M7_2P00435
      GPL8673_M7_2P01429
      GPL9450_M7.2
      cea2.p.96183
    Expression_cluster (178)
    Interaction: WBInteraction000028979
      WBInteraction000029068
      WBInteraction000030953
      WBInteraction000114760
      WBInteraction000114987
      WBInteraction000124350
      WBInteraction000141247
      WBInteraction000144646
      WBInteraction000145110
      WBInteraction000145477
      WBInteraction000146887
      WBInteraction000147020
      WBInteraction000147673
      WBInteraction000151395
      WBInteraction000152590
      WBInteraction000160821
      WBInteraction000162742
      WBInteraction000164754
      WBInteraction000168383
      WBInteraction000170368
      WBInteraction000172349
      WBInteraction000176045
      WBInteraction000176922
      WBInteraction000176953
      WBInteraction000181582
      WBInteraction000183120
      WBInteraction000184041
      WBInteraction000184159
      WBInteraction000185958
      WBInteraction000188683
      WBInteraction000188968
      WBInteraction000188983
      WBInteraction000189473
      WBInteraction000191534
      WBInteraction000191905
      WBInteraction000197456
      WBInteraction000202149
      WBInteraction000204038
      WBInteraction000204549
      WBInteraction000205535
      WBInteraction000206611
      WBInteraction000206786
      WBInteraction000208443
      WBInteraction000208837
      WBInteraction000208927
      WBInteraction000209158
      WBInteraction000209369
      WBInteraction000214874
      WBInteraction000215483
      WBInteraction000215798
      WBInteraction000216904
      WBInteraction000217074
      WBInteraction000218251
      WBInteraction000223991
      WBInteraction000224579
      WBInteraction000225051
      WBInteraction000225428
      WBInteraction000227382
      WBInteraction000227697
      WBInteraction000229242
      WBInteraction000230051
      WBInteraction000230482
      WBInteraction000231313
      WBInteraction000232580
      WBInteraction000233562
      WBInteraction000234251
      WBInteraction000237972
      WBInteraction000238557
      WBInteraction000240245
      WBInteraction000241369
      WBInteraction000241697
      WBInteraction000244209
      WBInteraction000244732
      WBInteraction000244934
      WBInteraction000246475
      WBInteraction000247331
      WBInteraction000248353
      WBInteraction000249337
      WBInteraction000250876
      WBInteraction000250909
      WBInteraction000251595
      WBInteraction000253291
      WBInteraction000253510
      WBInteraction000253665
      WBInteraction000254269
      WBInteraction000255250
      WBInteraction000255252
      WBInteraction000256233
      WBInteraction000257081
      WBInteraction000257133
      WBInteraction000258207
      WBInteraction000259256
      WBInteraction000260239
      WBInteraction000265260
      WBInteraction000266221
      WBInteraction000266275
      WBInteraction000267000
      WBInteraction000267141
      WBInteraction000268628
      WBInteraction000269063
      WBInteraction000270440
      WBInteraction000272570
      WBInteraction000276288
      WBInteraction000277892
      WBInteraction000278301
      WBInteraction000283617
      WBInteraction000283780
      WBInteraction000283818
      WBInteraction000286024
      WBInteraction000287429
      WBInteraction000288928
      WBInteraction000291673
      WBInteraction000292096
      WBInteraction000292833
      WBInteraction000293762
      WBInteraction000295028
      WBInteraction000295894
      WBInteraction000296092
      WBInteraction000296247
      WBInteraction000297109
      WBInteraction000303097
      WBInteraction000304437
      WBInteraction000305308
      WBInteraction000306141
      WBInteraction000309210
      WBInteraction000310668
      WBInteraction000311095
      WBInteraction000311319
      WBInteraction000312597
      WBInteraction000312810
      WBInteraction000312883
      WBInteraction000313236
      WBInteraction000314866
      WBInteraction000316531
      WBInteraction000316782
      WBInteraction000316948
      WBInteraction000318016
      WBInteraction000321553
      WBInteraction000322676
      WBInteraction000323324
      WBInteraction000327445
      WBInteraction000328047
      WBInteraction000330555
      WBInteraction000337676
      WBInteraction000338268
      WBInteraction000338957
      WBInteraction000341893
      WBInteraction000345340
      WBInteraction000346930
      WBInteraction000346953
      WBInteraction000349845
      WBInteraction000351433
      WBInteraction000352323
      WBInteraction000352806
      WBInteraction000353501
      WBInteraction000354817
      WBInteraction000357318
      WBInteraction000361831
      WBInteraction000363581
      WBInteraction000367121
      WBInteraction000373895
      WBInteraction000376128
      WBInteraction000376307
      WBInteraction000376801
      WBInteraction000376961
      WBInteraction000380783
      WBInteraction000381937
      WBInteraction000383765
      WBInteraction000384999
      WBInteraction000385597
      WBInteraction000390782
      WBInteraction000392015
      WBInteraction000394175
      WBInteraction000394448
      WBInteraction000394945
      WBInteraction000395452
      WBInteraction000396528
      WBInteraction000397735
      WBInteraction000397936
      WBInteraction000398023
      WBInteraction000401300
      WBInteraction000404437
      WBInteraction000404776
      WBInteraction000408919
      WBInteraction000409033
      WBInteraction000409222
      WBInteraction000411356
      WBInteraction000411717
      WBInteraction000412603
      WBInteraction000413500
      WBInteraction000413925
      WBInteraction000416545
      WBInteraction000419276
      WBInteraction000419499
      WBInteraction000419646
      WBInteraction000420734
      WBInteraction000422720
      WBInteraction000426547
      WBInteraction000426916
      WBInteraction000429687
      WBInteraction000430225
      WBInteraction000430417
      WBInteraction000433336
      WBInteraction000436498
      WBInteraction000437315
      WBInteraction000441608
      WBInteraction000441750
      WBInteraction000448933
      WBInteraction000449112
      WBInteraction000449562
      WBInteraction000451926
      WBInteraction000452706
      WBInteraction000458267
      WBInteraction000459437
      WBInteraction000459885
      WBInteraction000461376
      WBInteraction000461710
      WBInteraction000462310
      WBInteraction000462709
      WBInteraction000522213
      WBInteraction000523139
      WBInteraction000523151
      WBInteraction000543985
      WBInteraction000547462
      WBInteraction000571355
      WBInteraction000571356
      WBInteraction000571357
      WBInteraction000571360
      WBInteraction000571361
      WBInteraction000576950
      WBInteraction000585486
  Map_info: Map: IV Position: 4.83857 Error: 0.004896
    Positive: Positive_clone: M7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene