WormBase Tree Display for Gene: WBGene00003020

WBGene00003020 SMap: S_parent: Sequence: C32F10
  Identity: Version: 1
    Name: CGC_name: lin-35 Person_evidence: WBPerson261
      Sequence_name: C32F10.2
      Molecular_name: C32F10.2
        C32F10.2.1
        CE24823
      Other_name: CELE_C32F10.2 Accession_evidence: NDB BX284601
      Public_name: lin-35
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Allele (104)
    Legacy_information: n745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)).
      See also n373, n745
      [C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS]
    Strain (17)
    Component_of_genotype: WBGenotype00000009
    RNASeq_FPKM (74)
    GO_annotation (50)
    Ortholog (43)
    Structured_description: Concise_description: lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, loss of lin-35 activity results in enhanced RNA interference; lin-35 activity is also required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells. Paper_evidence: WBPaper00003329
            WBPaper00004635
            WBPaper00005137
            WBPaper00005931
            WBPaper00024215
            WBPaper00024320
            WBPaper00024322
            WBPaper00024692
            WBPaper00027135
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 05 May 2009 00:00:00
      Automated_description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1059 Homo sapiens Paper_evidence: WBPaper00024322
          Accession_evidence: OMIM 309580
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 Apr 2013 00:00:00
    Potential_model (16)
    Disease_relevance: Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. Homo sapiens Paper_evidence: WBPaper00024322
            WBPaper00024692
            WBPaper00003646
          Curator_confirmed: WBPerson324
          Date_last_updated: 23 Apr 2013 00:00:00
  Models_disease_asserted: WBDOannot00000614
    WBDOannot00001021
  Molecular_info: Corresponding_CDS: C32F10.2
    Corresponding_transcript: C32F10.2.1
    Associated_feature: WBsf643315
      WBsf643316
      WBsf656335
      WBsf656336
      WBsf656337
      WBsf656338
      WBsf983774
      WBsf217712
    Gene_product_binds: WBsf977574
      WBsf977575
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      WBsf977949
    Transcription_factor: WBTranscriptionFactor000270
  Experimental_info: RNAi_result (78)
    Expr_pattern: Chronogram622
      Expr1291
      Expr3128
      Expr1015789
      Expr1031411
      Expr1145718
      Expr2013177
      Expr2031409
    Drives_construct: WBCnstr00004066
      WBCnstr00006281
      WBCnstr00011156
      WBCnstr00017294
      WBCnstr00036281
    Construct_product: WBCnstr00006281
      WBCnstr00011156
      WBCnstr00017287
      WBCnstr00017294
      WBCnstr00017295
      WBCnstr00017296
      WBCnstr00021077
      WBCnstr00021078
      WBCnstr00021079
      WBCnstr00036281
    Regulate_expr_cluster (16)
    Antibody (4)
    Microarray_results (20)
    Expression_cluster (156)
    Interaction (322)
    Product_binds_matrix: WBPmat00005534
      WBPmat00005535
      WBPmat00005536
      WBPmat00005540
      WBPmat00005541
      WBPmat00005542
      WBPmat00005543
      WBPmat00005544
      WBPmat00005545
  Map_info: Map: I Position: 0.461719 Error: 0.000997
    Well_ordered
    Positive: Positive_clone: C32F10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 283
        308
        309
        4517
  Reference (253)
  Picture: WBPicture0000013091
  Method: Gene