WormBase Tree Display for Gene: WBGene00006911
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| WBGene00006911 | SMap | S_parent | Sequence | R10E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vha-2 | |||||||
| Sequence_name | R10E11.2 | ||||||||
| Molecular_name | R10E11.2 | ||||||||
| R10E11.2.1 | |||||||||
| CE06290 | |||||||||
| Other_name | CELE_R10E11.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | vha-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vha | ||||||||
| Allele (11) | |||||||||
| Legacy_information | [Oka T, Yamamoto R, Futai M] vha for Vacuolar-type H+ ATPase. Encodes 16kD proteolipid. Downstream gene in operon with vha-1. vha-2::GFP strongly expressed in excretory cell, rectum and two post-anal cells. Predicted gene R10E11.2 | ||||||||
| Strain | WBStrain00031520 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP3620 | ||||||||
| Ortholog (55) | |||||||||
| Paralog | WBGene00006910 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006913 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006912 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound(V0) domain of vacuolar proton-translocating ATPase (V-ATPase); theprotein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is apredicted V-ATPase transmembrane rotor component, whose polypeptidesequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise aclosely related family of subunit c co-orthologs, predicted to carryprotons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32)for transmembrane export; VHA-2/3 is dispensable for viability, sincevha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 isrequired for ovulation and embryogenesis, since vha-2(RNAi) animals aresterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 andprobably all V-ATPase subunits, is required for systemic RNAi, probablyduring endocytotic RNAi uptake; VHA-2 is required for necrosis, sincevha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares anoperon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed inthe excretory cell, the rectum, and a pair of cells posterior to theanus. | Paper_evidence | WBPaper00002899 | |||||
| WBPaper00003195 | |||||||||
| WBPaper00004341 | |||||||||
| WBPaper00027349 | |||||||||
| WBPaper00027697 | |||||||||
| WBPaper00027766 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| WBPaper00028775 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in programmed cell death and proton transmembrane transport. Predicted to be located in membrane. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Expressed in excretory cell and rectum. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Is an ortholog of human ATP6V0C (ATPase H+ transporting V0 subunit c). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3963 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:855) | ||||
| DOID:0070472 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:855) | ||||||
| Molecular_info | Corresponding_CDS | R10E11.2 | |||||||
| Corresponding_transcript | R10E11.2.1 | ||||||||
| Other_sequence (91) | |||||||||
| Associated_feature (8) | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr1398 | ||||||||
| Expr1461 | |||||||||
| Expr1015085 | |||||||||
| Expr1032928 | |||||||||
| Expr1155367 | |||||||||
| Expr2017988 | |||||||||
| Expr2036124 | |||||||||
| Drives_construct | WBCnstr00010290 | ||||||||
| WBCnstr00034103 | |||||||||
| Construct_product | WBCnstr00010290 | ||||||||
| WBCnstr00034103 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (65) | |||||||||
| WBProcess | WBbiopr:00000003 | ||||||||
| Map_info | Map | III | Position | 1.06192 | Error | 0.006664 | |||
| Positive | Positive_clone | R10E11 | Person_evidence | WBPerson5079 | |||||
| WBPerson5074 | |||||||||
| Author_evidence | Yamamoto R | ||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 5015 | |||||||
| 4231 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Data extracted from Oka et al. (1997) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
