WormBase Tree Display for Gene: WBGene00006823
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| WBGene00006823 | SMap | S_parent | Sequence | C06A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-94 | Paper_evidence | WBPaper00030711 | |||||
| Person_evidence | WBPerson261 | ||||||||
| Sequence_name | C06A5.7 | ||||||||
| Molecular_name | C06A5.7a | ||||||||
| C06A5.7a.1 | |||||||||
| CE29023 | |||||||||
| C06A5.7b | |||||||||
| CE29024 | |||||||||
| C06A5.7a.2 | |||||||||
| C06A5.7b.1 | |||||||||
| Other_name | tmd-1 | ||||||||
| tropomodulin | Paper_evidence | WBPaper00024219 | |||||||
| CELE_C06A5.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-94 | ||||||||
| DB_info | Database | AceView | gene | 1G570 | |||||
| WormQTL | gene | WBGene00006823 | |||||||
| WormFlux | gene | WBGene00006823 | |||||||
| NDB | locus_tag | CELE_C06A5.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006823|UniProtKB=O01479 | |||||||
| family | PTHR10901 | ||||||||
| NCBI | gene | 172275 | |||||||
| RefSeq | protein | NM_059334.5 | |||||||
| NM_001392388.1 | |||||||||
| SwissProt | UniProtAcc | O01479 | |||||||
| UniProt_GCRP | UniProtAcc | O01479 | |||||||
| OMIM | gene | 602715 | |||||||
| 608006 | |||||||||
| 616112 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 09 Jan 2008 15:44:04 | WBPerson2970 | Event | Acquires_merge | WBGene00006581 | ||||
| Name_change | Other_name | tmd-1 | |||||||
| Acquires_merge | WBGene00006581 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00248856 | ||||||||
| Allele (114) | |||||||||
| Legacy_information | [C.elegansII] su177 : slow, especially in adult; abnormal patchy muscle birefringence and ultrastructure; collections of thin and `intermediate' filaments (no staining with anti-intermediate filament antibodies). ES2 ME2. NA1. [Zengel and Epstein 1980; HE] | ||||||||
| Strain | WBStrain00002776 | ||||||||
| WBStrain00036100 | |||||||||
| WBStrain00007705 | |||||||||
| WBStrain00008394 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (60) | |||||||||
| Paralog | WBGene00006582 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-94 encodes two isoforms of tropomodulin; UNC-94 functions synergistically with other actin filament regulators to effect proper sarcomeric actin filament organization and hence, locomotion; UNC-94 is expressed in muscle cells and localizes to the ends of actin thin filaments. | Paper_evidence | WBPaper00000488 | |||||
| WBPaper00001912 | |||||||||
| WBPaper00032351 | |||||||||
| WBPaper00032338 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 29 Mar 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable tropomyosin binding activity. Involved in several processes, including myofibril assembly; nematode larval development; and pointed-end actin filament capping. Located in striated muscle thin filament and terminal web. Expressed in intestine; pharyngeal muscle cell; seam cell; spermatheca; and uterine muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2G; megacystis-microcolon-intestinal hypoperistalsis syndrome; and nemaline myopathy 10. Is an ortholog of several human genes including TMOD1 (tropomodulin 1); TMOD3 (tropomodulin 3); and TMOD4 (tropomodulin 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110931 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6649) | ||||
| DOID:0081163 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6648) | ||||||
| DOID:0060610 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6647) | ||||||
| Molecular_info | Corresponding_CDS | C06A5.7a | |||||||
| C06A5.7b | |||||||||
| Corresponding_transcript | C06A5.7a.1 | ||||||||
| C06A5.7a.2 | |||||||||
| C06A5.7b.1 | |||||||||
| Other_sequence (57) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (3) | |||||||||
| Construct_product | WBCnstr00013641 | ||||||||
| WBCnstr00013642 | |||||||||
| Antibody | WBAntibody00001482 | ||||||||
| WBAntibody00002350 | |||||||||
| WBAntibody00002516 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction (30) | |||||||||
| Map_info | Map | I | Position | 0.663494 | Error | 0.012833 | |||
| Positive | Positive_clone | C06A5 | Inferred_automatically (2) | ||||||
| Mapping_data | 2_point | 391 | |||||||
| Multi_point | 310 | ||||||||
| 311 | |||||||||
| 312 | |||||||||
| 4638 | |||||||||
| Reference (25) | |||||||||
| Method | Gene |
