WormBase Tree Display for Gene: WBGene00006701
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| WBGene00006701 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C35B1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ubc-1 | Person_evidence | WBPerson89 | |||||
| Sequence_name | C35B1.1 | ||||||||
| Molecular_name | C35B1.1 | ||||||||
| C35B1.1.1 | |||||||||
| CE27822 | |||||||||
| Other_name | CELE_C35B1.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | ubc-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ubc | ||||||||
| Allele (42) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes ubiquitin conjugating enzyme, homolog of yeast UBC2/RAD6 (52% partial sequence identity). Cosmid C04E2. [PC] | ||||||||
| Strain | WBStrain00002440 | ||||||||
| WBStrain00002286 | |||||||||
| WBStrain00055625 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Contained_in_operon | CEOP4112 | ||||||||
| Ortholog (40) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | ubc-1 encodes an E2 ubiquitin-conjugating enzyme that contains a novel 40 amino acid C-terminal tail, and is homologous to Saccharomyces cerevisiae RAD6/UBC2 which is involved in DNA repair; although loss of UBC-1 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, UBC-1 is able to complement the DNA repair defects of a Saccharomyces cerevisiae rad6 null mutant, suggesting that UBC-1 can function in the DNA repair pathway; ubc-1 mRNA is detectable in embryos. | Paper_evidence | WBPaper00002313 | |||||
| WBPaper00002928 | |||||||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Jan 2005 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in DNA repair and protein ubiquitination. Part of ubiquitin conjugating enzyme complex. Expressed in head and tail. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Is an ortholog of human UBE2B (ubiquitin conjugating enzyme E2 B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060820 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12472) | ||||
| Molecular_info | Corresponding_CDS | C35B1.1 | |||||||
| Corresponding_transcript | C35B1.1.1 | ||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf034297 | ||||||||
| WBsf660068 | |||||||||
| WBsf228152 | |||||||||
| WBsf228153 | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Chronogram1685 | ||||||||
| Expr5430 | |||||||||
| Expr5431 | |||||||||
| Expr1018771 | |||||||||
| Expr1032784 | |||||||||
| Expr1145963 | |||||||||
| Expr2017706 | |||||||||
| Expr2035844 | |||||||||
| Drives_construct | WBCnstr00002986 | ||||||||
| WBCnstr00004486 | |||||||||
| Antibody | WBAntibody00001819 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (136) | |||||||||
| Map_info (4) | |||||||||
| Reference (24) | |||||||||
| Remark | C35B1.f changing to .1 on basis of ubiquitin-conjugation. [sdm 0103] | ||||||||
| Sequence connection from [Boulton S, Vidal M] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
